Mechanistic Insights into Influenza A Virus-Induced Cell Death and Emerging Treatment Strategies DOI Creative Commons

Yuling Sun,

Kaituo Liu

Veterinary Sciences, Год журнала: 2024, Номер 11(11), С. 555 - 555

Опубликована: Ноя. 10, 2024

Influenza A virus (IAV) infection initiates a complex interplay of cell death modalities, including apoptosis, necroptosis, pyroptosis, and their integration, known as PANoptosis, which significantly impacts host immune responses tissue integrity. These pathways are intricately regulated by viral proteins factors, contributing to both clearance pathogenesis-related damage. This review comprehensively explores the molecular mechanisms underlying these processes in influenza infection. We highlight roles key regulatory proteins, such ZBP1 (Z-DNA binding protein 1) RIPK3 (receptor-interacting kinase 3), orchestrating responses, emphasizing dual antiviral defense injury. Furthermore, we discuss emerging therapeutic strategies targeting pathways, aiming enhance efficacy while minimizing collateral Future research should focus on targeted approaches modulate mechanisms, reduce damage improve clinical outcomes for patients with severe influenza.

Язык: Английский

Macrophage polarization and its impact on idiopathic pulmonary fibrosis DOI Creative Commons

Zhouling Ge,

Yong Q. Chen,

Leikai Ma

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 26, 2024

Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing in the lungs and ultimately resulting respiratory failure high risk of death. Macrophages play crucial role immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, impacting development IPF. Recent research has indicated polarization onset progression M1 secrete inflammatory cytokines agents early damage fibrosis, while M2 support tissue healing releasing cytokines. Developing novel treatments for IPF relies on thorough comprehension processes involved macrophage The review outlines regulation its impact IPF, with goal investigating possible therapeutic benefits advancement

Язык: Английский

Процитировано

12
Endoplasmic reticulum stress in diseases DOI Creative Commons
Yingying Liu, Chunling Xu, Renjun Gu

и другие.

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Авг. 26, 2024

The endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for wide range of vital functions, including the modification, folding, and trafficking proteins, as well biosynthesis lipids maintenance intracellular calcium homeostasis. A variety factors can disrupt function ER, leading to aggregation unfolded misfolded proteins within its confines induction ER stress. conserved cascade signaling events known protein response (UPR) has evolved relieve burden restore However, these processes culminate cell death while stress sustained over an extended period at elevated levels. This review summarizes potential role UPR determining fate various diseases, cardiovascular neurodegenerative metabolic autoimmune fibrotic viral infections, cancer. It also puts forward that manipulation this intricate pathway may represent novel target drug discovery innovative therapeutic strategies context human diseases.

Язык: Английский

Процитировано

10
Dioscin pretreatment ameliorates ferroptosis in cardiomyocytes after myocardial infarction via inhibiting endoplasmic reticulum stress DOI Creative Commons

Chang Wu,

X. Shen,

Pan Lou

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

1
The crosstalk between DNA-damage responses and innate immunity DOI Creative Commons

Mei He,

Hua Jiang,

Shun Li

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 140, С. 112768 - 112768

Опубликована: Июль 31, 2024

DNA damage is typically caused during cell growth by replication stress or exposure to endogenous external toxins. The accumulation of damaged causes genomic instability, which the root cause many serious disorders. Multiple cellular organisms utilize sophisticated signaling pathways against damage, collectively known as response (DDR) networks. Innate immune responses are activated following abnormalities, including damage. Interestingly, recent studies have indicated that there an intimate relationship between DDR network and innate responses. Diverse kinds cytosolic sensors, such cGAS STING, recognize induce signals related responses, link defective immunity. Moreover, components operate in IFNs and/or a cascade inflammatory cytokines via direct interactions with modulators. Consistently, factors exacerbate imbalance, resulting severe diseases, autoimmune disorders tumorigenesis. Here, latest progress understanding crosstalk reviewed. Notably, dual function modulators may provide novel insights into developing targeted immunotherapies for damage-related even carcinomas.

Язык: Английский

Процитировано

7
The “root” causes behind the anti-inflammatory actions of ginger compounds in immune cells DOI Creative Commons
Kitti Pázmándi, Attila Gábor Szöllősi, Tünde Fekete

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 28, 2024

Ginger (

Язык: Английский

Процитировано

6
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis DOI Creative Commons

Yuling Sun,

Lei Ji, Wei Liu

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 23, 2024

Abstract Many DNA viruses develop various strategies to inhibit cell death facilitate their replication. However, whether influenza A virus (IAV), a fast-replicating RNA virus, attenuates remains unknown. Here, we report that IAV infection induces TAK1 phosphorylation in murine alveolar epithelial line (LET1) and fibroblastoma (L929). The TAK1-specific inhibitor 5Z-7-Oxzeneonal (5Z) knockout significantly enhance IAV-induced apoptosis, as evidenced by increased PARP, caspase-8, caspase-3 cleavage. inhibition also increases necroptosis RIPK1 S166 , RIPK3 T231/S232 MLKL S345 phosphorylation. Mechanistically, activates IKK, which phosphorylates S25 inhibits its activation. p38 downstream kinase MK2, S321 but does not affect Further investigation revealed the Nec-1 abrogate apoptosis necroptosis; re-expression of wild-type kinase-dead (KD)-RIPK1 restores death. ZBP1 abrogates death, whereas apoptosis. 5Z treatment enhances slightly reduces inflammatory response lungs H1N1 virus-infected mice prolongs survival IAV-infected mice. Our study provides evidence suppress RIPK1-dependent necroptosis, is required for cells.

Язык: Английский

Процитировано

6
TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways DOI Creative Commons
Junying Wang, Ling Wang,

Wenting Lu

и другие.

Mucosal Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

5
1,25-D3 ameliorates ischemic brain injury by alleviating endoplasmic reticulum stress and ferroptosis: Involvement of vitamin D receptor and p53 signaling DOI
Ting Song, Jian‐Dong Li, Yulei Xia

и другие.

Cellular Signalling, Год журнала: 2024, Номер 122, С. 111331 - 111331

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

4
Therapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content DOI Creative Commons
Danielle J. Beetler,

Presley Giresi,

Damian N. Di Florio

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Extracellular vesicles (EVs) can potently inhibit inflammation yet there is a lack of understanding about the impact donor characteristics on efficacy EVs. The goal this study was to determine whether sex and age platelet-derived EVs (PEV) affected their ability viral myocarditis. PEV, isolated from men women all ages, compared PEV obtained under 50 years age, which we termed premenopausal (pmPEV). Because protective effect estrogen against myocardial inflammation, hypothesized that pmPEV would be more effective than at inhibiting We injected pmPEV, or vehicle control in mouse model myocarditis examined histology, gene expression, protein profiles, performed proteome microRNA (miR) sequencing found both significantly inhibited myocarditis; however, effective, confirmed by greater reduction inflammatory cells proinflammatory profibrotic markers determined using expression immunohistochemistry. Proteome miR revealed miRs specifically targeted antiviral, Toll-like receptor (TLR)4, inflammasome pathways known contribute while contained general immunoregulatory miRs. These differences EV content corresponded differing anti-inflammatory effects two types

Язык: Английский

Процитировано

0
Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection DOI Creative Commons

Shaqiu Zhang,

Jinku Li,

Mingshu Wang

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Avian reovirus (ARV), a double-stranded RNA virus, frequently induces immunosuppression in poultry, leading to symptoms such as irregular bleeding and spleen necrosis infected ducks. Since 2017, the morbidity mortality rates associated with ARV infection poultry have been on rise, progressively emerging significant viral disease impacting duck farming industry China. In our study, we collected embryo fibroblasts 18 h post-infection conducted transcriptome sequencing analysis. The analysis revealed that 3,818 mRNA expressions were up-regulated, 4,573 down-regulated, 472 long noncoding RNAs (LncRNAs) 345 lncRNAs down-regulated. We employed qRT-PCR validate results, confirming their accuracy. data indicated upregulation of PARP9 , TLR7 TRIM33 ATG5 genes, suggesting potential involvement infection. Notably, study identified novel functional lncRNA, MSTRG.9284.1 (It was named linc000889 present study), which inhibits replication at transcriptional, translational levels titer. Overall, this has numerous ARV-induced differentially expressed mRNAs lncRNAs, including lncRNA replication. This discovery provides new insights into mechanisms may contribute development prevention treatment strategies.

Язык: Английский

Процитировано

0