Deciphering the potential role of post-translational modifications of histones in gastrointestinal cancers: a proteomics-based review with therapeutic challenges and opportunities DOI Creative Commons
Reyhaneh Farrokhi Yekta, Masoumeh Farahani, Mehdi Koushki

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Окт. 21, 2024

Oncogenesis is a complex and multi-step process, controlled by several factors including epigenetic modifications. It considered that histone modifications are critical components in the regulation of gene expression, protein functions, molecular interactions. Dysregulated post-translationally modified histones related enzymatic systems key players control cell proliferation differentiation, which associated with onset progression cancers. The most traditional investigations on cancer have focused mutations oncogenes tumor suppressor genes. However, increasing evidence indicates epigenetics, especially post-translational (PTMs) play important roles various types. Mass spectrometry-based proteomic approaches demonstrated tremendous potential PTMs profiling quantitation different biological systems. In this paper, we made proteomics-based review role involved gastrointestinal cancers (GCs) tumorigenesis processes. These alterations function not only as diagnostic or prognostic biomarkers for GCs, but deeper comprehension GCs could facilitate treatment prevalent malignancy through creation more effective targeted therapies.

Язык: Английский

Exploring the role of mitochondrial antiviral signaling protein in cardiac diseases DOI Creative Commons

Yuying Qi,

Jie Yin, Weiwei Xia

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

Mitochondrial antiviral signaling (MAVS) was first discovered as an activator of NF-κB and IRF3 in response to viral infection 2005. As a key innate immune adapter that acts 'on/off' switch against most RNA viruses. Upon interaction with RIG-I, MAVS aggregates activate downstream pathway. The gene, located on chromosome 20p13, encodes 540-amino acid protein the outer membrane mitochondria. ubiquitously expressed higher levels heart, skeletal muscle, liver, placenta peripheral blood leukocytes. Recent studies have reported be associated various conditions including cancers, systemic lupus erythematosus, kidney disease, cardiovascular disease. This article provides comprehensive summary description research cardiac encompassing structure, expression, protein-protein interactions, modifications, well role heart It is aimed establish scientific foundation for identification potential therapeutic target.

Язык: Английский

Процитировано

0
A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication DOI Creative Commons

Yaotang Wu,

Yang‐Chang Wu, Chenlu Wang

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)

Опубликована: Фев. 22, 2025

RNA interference (RNAi) and autophagy are two pivotal biological processes that regulate virus replication. This study explored the complex relationship between RNAi in controlling influenza Initially, we reported (H9N2) infection increases viral load expression of markers while inhibiting pathway. Subsequent studies employing enhancer inhibitor treatments confirmed avian (AIV, H9N2) promotes replication by enhancing pathways. Further analysis revealed ATG7, an protein, can interact with dicer to affect its antiviral functions. Finally, discovered other viruses, including infectious bursal disease (IBDV) bronchitis (IBV), induced upregulation which blocked pathway facilitate Our findings suggested might trigger downregulation pathway, revealing a interaction these defence against

Язык: Английский

Процитировано

0
HSV-1 as a gene delivery platform for cancer gene therapy DOI

Yangkun Shen,

Hucheng Zhang,

Mengzhou Xue

и другие.

Trends in Pharmacological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
A case report of severe myocarditis combined with erythema multiforme caused by herpes simplex virus-1 DOI Creative Commons

Anwu Huang,

Bin Lin,

Xiaojun Ji

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 12, 2025

Herpes simplex virus-1 (HSV-1) is a recognised pathogen that primarily associated with skin mucosal infection. However, in rare cases, it has been observed to lead extramucosal manifestations, including myocarditis. The present case report documents the occurrence of severe myocarditis 35-year-old female patient, attributed HSV-1 She received cardiac support form VA-ECMO (Venoarterial Extracorporeal Membrane Oxygenation). Concurrently, patient exhibited cutaneous manifestations erythema multiforme, which demonstrated favourable response antiviral and hormonal therapy. This underscores significance as causative agent necessity for vigilance expeditious treatment potential complications caused by HSV-1.

Язык: Английский

Процитировано

0
Dynamic interplay between RNA N6-methyladenosine modification and porcine reproductive and respiratory syndrome virus infection DOI Creative Commons
Zihan Wang, Jing Li,

Sai-Ya Ma

и другие.

Veterinary Research, Год журнала: 2025, Номер 56(1)

Опубликована: Март 22, 2025

Abstract N 6 -methyladenosine (m A) has attracted significant attention for its role in regulating the complex interaction between viruses and host cells. Porcine reproductive respiratory syndrome virus (PRRSV) is a pathogen affecting swine health worldwide. Here, we first identified seven m A-enriched peaks PRRSV genomic RNA by A immunoprecipitation sequencing A-seq). Moreover, functional analyses revealed positive correlation modification level replication. Treatment with universal methylation inhibitor 3-deazaadenosine (3-DAA) effectively suppressed replication dose-dependent manner. Furthermore, A-seq was also used to determine landscape of transcriptome PAMs infected pandemic or highly pathogenic strains. Among 4677 transcripts exhibiting altered levels, MAPK14 gene p38/MAPK signalling pathway emerged as preliminary targets A-mediated epigenetic regulation during infection. These findings provide new insights into mechanisms underlying infection may facilitate development anti-PRRSV therapeutics.

Язык: Английский

Процитировано

0
Immunogenicity and protective efficacy of an inactivated bivalent vaccine containing two recombinant H1N1 and H3N2 swine influenza virus strains DOI Creative Commons
Heng Zhang, Xu Chen, Dongying Liu

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)

Опубликована: Апрель 7, 2025

The wild-type H1N1 and H3N2 swine influenza virus (SIV) strains are unsuitable for vaccine production because of high lethality in chicken embryos low reproductive titers. This study developed recombinant H1N1-Re1 H3N2-Re1 via HA NA genes from the SW/GX/755/17 SW/GX/1659/17 combined with six internal A/PR/8/34 strain. viruses demonstrated typical cytopathic effects MDCK cells, presence viral particles was confirmed electron microscopy. Growth curve analysis revealed titers 108.31 108.17 EID50 per 100 µL H3N2-Re1, respectively, within 72-96 h postinoculation. Virus stocks were used to produce a bivalent inactivated vaccine. After two immunizations, hemagglutination inhibition piglets significantly greater than those induced by commercial vaccines sustained 5 29 weeks postimmunization. Upon challenge virulent SIV strains, isolation occurred all pigs PBS group (5/5 protection), whereas no detected (0/5). In contrast, had rate 1/5. Pathological examination severe pulmonary lesions group, mild changes (1/5), normal lung morphology group. successful application an eight-plasmid reverse genetics system develop enhanced immunogenicity replication efficiency. provides prolonged complete protection against offering robust tool controlling evolving variants.

Язык: Английский

Процитировано

0
Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3 DOI Creative Commons
Zihan Chen, J. Wang,

Baochun Lu

и другие.

BMC Veterinary Research, Год журнала: 2025, Номер 21(1)

Опубликована: Апрель 9, 2025

Lumpy skin disease virus (LSDV) causes lumpy disease, which is one of the most devastating ruminant diseases. The pathogenesis remains largely unknown; however, seriously threatens global cattle-farming industry. In our previous study, we found that LSDV 142 gene deletion affected proliferation in cells and was an early involved infection. Additionally, study ORF142 inhibits production interferon beta. Herein, report host antiviral response. results revealed protein inhibited interferon-promoter activation. suppresses response by blocking beta (IFN-β) based on 381-417 amino acids at C-terminal domain site regulatory factor 3 (IRF3). interacts with IRF3 interferes recruitment to TANK-binding kinase 1 (TBK1) a dose-dependent manner, preventing nuclear translocation IRF3. These suggest antagonizes innate immunity affecting binding between Our findings provide new information regarding this virus.

Язык: Английский

Процитировано

0
PERK/Sestrin2 Signaling Pathway Mediated Autophagy Regulates Human Cardiomyocytes Apoptosis Induced by Traffic-Related PM2.5 and Diverse Constituents DOI Open Access

Jiayu Tian,

Zeyu Niu,

Huan Yang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3784 - 3784

Опубликована: Апрель 17, 2025

Although the strong causal association between PM2.5 and cardiovascular disease has been extensively studied, latent molecular mechanisms have not entirely explained. The objective of this research was to assess cardiotoxicity Traffic-related (TRPM2.5), water-soluble components (WSC), water-insoluble (WIC) in human cardiomyocytes (AC16) investigate underlying mechanisms. Endoplasmic reticulum stress (ERS), autophagy, apoptosis were activated 24 h after exposure total-TRPM2.5, WSC, or WIC. WIC predominantly related compared WSC. Sestrin2 is an upstream molecule several signaling pathways, including those involved autophagy apoptosis. In study, we found that knockdown Protein Kinase RNA-like Reticulum (PERK) suppressed expression PERK, Sestrin2, Caspase-12, Caspase-3, LC3, p62 TRPM2.5-treated AC16 cells. These results indicate ERS participates activation through PERK/Sestrin2 pathway. We inhibiting with 3-methyladenine (3-MA) decreased autophagy-related factors aggravated observations suggest protective initiated. Finally, our findings provide valuable insights into mechanism by which might regulate pathway, may be relieve TRPM2.5 component-mediated

Язык: Английский

Процитировано

0
Advances in neutrophil extracellular traps and ferroptosis in sepsis-induced cardiomyopathy DOI Creative Commons

Man Zeng,

Youhong Niu, Jiahao Huang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 28, 2025

Sepsis-induced cardiomyopathy is a reversible non-ischemic acute cardiac dysfunction associated with sepsis. It strongly an abnormal immune response. emerges as vital threat to public health owing its high mortality rate. However, the exact pathogenesis requires further investigation. In recent years, NETosis and ferroptosis, which are novel modes of programmed cell death, have been identified found play important roles in sepsis-related organ damage. This article outlines mechanisms these two discusses role neutrophil extracellular traps myocardial injury importance ferroptosis sepsis-induced cardiomyopathy, reviews potential interconnection between types death cardiomyopathy.

Язык: Английский

Процитировано

0
Avian Reovirus: From Molecular Biology to Pathogenesis and Control DOI Creative Commons
Islam Nour, Sujit K. Mohanty

Viruses, Год журнала: 2024, Номер 16(12), С. 1966 - 1966

Опубликована: Дек. 23, 2024

Avian reoviruses (ARVs) represent a significant economic burden on the poultry industry due to their widespread prevalence and potential pathogenicity. These viruses, capable of infecting diverse range avian species, can lead variety clinical manifestations, most notably tenosynovitis/arthritis. While many ARV strains are asymptomatic, pathogenic variants cause severe inflammation tissue damage in organs such as tendons, heart, liver. In broilers turkeys, ARVs induce arthritis/tenosynovitis, characterized by swollen hock joints lesions gastrocnemius tendons. Additionally, have been implicated other diseases, although precise role these conditions remains be fully elucidated. recent years, cases surged United States, emphasizing need for effective control measures. Routine vaccination with commercial or autogenous vaccines is currently primary strategy mitigating ARV's impact. Future research efforts should focus enhancing our understanding ARV-induced pathogenesis, identifying host factors that influence disease severity, developing novel based ongoing surveillance circulating strains. This review aims explore molecular aspects ARV, including virus structure, replication, epidemiology, roles its encoded proteins immune response infection. Furthermore, we discuss diagnostic approaches reovirus biosecurity measures trials combating antiviral strategies.

Язык: Английский

Процитировано

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