Living photosynthetic microneedle patches for in situ oxygenation and postsurgical melanoma therapy DOI Creative Commons
Jinxuan Jia, Xuhong Guo, Y. Wang

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 11, 2024

Surgical excision remains the principal treatment for melanoma, while tumor recurrence and delayed wound healing often occur due to residual cells hypoxic microenvironment in postoperative skin wounds. Herein, we present a living photosynthetic microneedle (MN) patch (namely MA/CM@MN) loaded with microalgae (MA) cuttlefish melanin (CM) postsurgical melanoma therapy healing. Benefiting from oxygenic photosynthesis of alive MA MN base, MA/CM@MN can generate oxygen under light exposure, thus facilitating cell proliferation protecting against hypoxia-induced death. In addition, CM nanoparticles embedded tips, be effectively heated up near-infrared (NIR) irradiation, contributing strong killing efficacy on vitro. Further experiments demonstrate that NIR-irradiated prevents local simultaneously promotes tumor-induced wounds after incomplete resection melanoma-bearing mice, probably because inhibit proliferation, stimulate apoptosis, mitigate tissue hypoxia light. These results indicate offers an effective therapeutic strategy cancer applications.

Язык: Английский

Advances in Hydrogel-Based Drug Delivery Systems DOI Creative Commons
Boya Liu, Kuo Chen

Gels, Год журнала: 2024, Номер 10(4), С. 262 - 262

Опубликована: Апрель 13, 2024

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.

Язык: Английский

Процитировано

42
Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment DOI Creative Commons

Yunheng Liu,

Lei Si, Yuxuan Jiang

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 705 - 721

Опубликована: Янв. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Язык: Английский

Процитировано

2
Nanotechnology based gas delivery system: a “green” strategy for cancer diagnosis and treatment DOI Creative Commons
Meixu Chen,

Tianyue Xu,

Linlin Song

и другие.

Theranostics, Год журнала: 2024, Номер 14(14), С. 5461 - 5491

Опубликована: Янв. 1, 2024

Gas therapy, a burgeoning clinical treatment modality, has garnered widespread attention to treat variety of pathologies in recent years. The advent nanoscale gas drug therapy represents novel therapeutic strategy, particularly demonstrating immense potential the realm oncology. This comprehensive review navigates landscape gases endowed with anti-cancer properties, including hydrogen (H

Язык: Английский

Процитировано

8
Self‐Cascade of ROS/Glucose‐Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF‐κB Pathway DOI Open Access
Wei Meng, Xiaotong Chen, Yanyan Chen

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, blood glucose levels, and recalcitrant bacterial infections. This is accompanied long‐term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, hybridized novel gold‐palladium (AuPd) nanoshell the injectable/injectable hydrogel system UiO/AuPd shells /BNN6/PEG@Gel (UAPsBP@Gel) developed. The capable acting as nitric oxide (NO) reactor utilizing synergistic therapy that harnesses NIR‐II light‐triggered photothermal effects controlled release NO gas for treatment to eradicate biofilm infections at different depths. AuPd nanoshells exhibits superoxide dismutase (SOD)‐, oxidase (GOx)‐, catalase (CAT)‐like activities, enabling self‐cascade process scavenging both reactive oxygen species (ROS) glucose. activity reshapes DUs microenvironment, switches on Nrf2/HO‐1 pathway inhibits NF‐κB pathway, promotes macrophage polarization toward anti‐inflammatory M2 phenotype, reduces resulting in efficient immunomodulation. In vitro / vivo results demonstrate UAPsBP@Gel can multifacetedly enhance epithelial rejuvenation through wound hemostasis, pro‐cellular migration vascularization. These highlight programmed therapeutic based UBAPsP@Gel tailored stages infected meet complex needs.

Язык: Английский

Процитировано

1
Algae-inspired chitosan-pullulan-based multifunctional hydrogel for enhanced wound healing DOI

Taishan Liu,

Huan Lei, Linlin Qu

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 347, С. 122751 - 122751

Опубликована: Сен. 15, 2024

Язык: Английский

Процитировано

7
Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity DOI
Yang Fu, Xiaoxiao Zhu, Lulu Ren

и другие.

ACS Nano, Год журнала: 2024, Номер 18(23), С. 14877 - 14892

Опубликована: Май 29, 2024

Effective anticancer immunity depends on properly activating multiple stepwise events in the cancer-immunity cycle. An immunologically "cold" tumor microenvironment (TME) engenders immune evasion and refractoriness to conventional checkpoint blockade immunotherapy. Here, we combine nanoparticle formulations an situ formed hydrogel scaffold treat accessible tumors locally stimulate systemic against metastatic lesions. The nanoparticles encapsulate poly(ε-caprolactone)-derived cytotoxic chemotherapy adjuvant of Toll-like receptor 7/8 through a reactive oxygen species (ROS)-cleavable linker that can be self-activated by coassembled neighboring photosensitizer following near-infrared (NIR) laser irradiation. Further development results syringeable, NIR light-responsive, immunogenic (iGEL) implanted peritumorally deposited into surgical bed. Upon irradiation, generated ROS induces iGEL degradation bond cleavage polymer–drug conjugates, triggering cell death cascade cancer cells spontaneously releasing encapsulated agents rewire Notably, upon application preclinical models melanoma triple-negative breast cancer, which are aggressive refractory immunotherapy, durable remission established tumors, extends postsurgical tumor-free survival, inhibits burden. result this study is administrable for host improve immunotherapeutic efficacy with minimal off-target side effects.

Язык: Английский

Процитировано

5
A Hydrogel Engineered with Semiconductive MnPSe3 Nanosheets as an Integrative Sonosensitizer/Fenton‐Like Catalyst/Nutrient for Melanoma Postoperative Care DOI Open Access
Xinxin Zhang, Jimin Huang, Jinzhou Huang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract The simultaneous inhibition of tumor recurrence and promotion wound healing are critical for patients undergoing melanoma surgery. However, the development an effective yet straightforward platform that meets comprehensive therapeutic requirements clinical postoperative care still remains a significant challenge. Herein, 2D semiconductive MnPSe 3 nanosheets (MPS NSs)‐engineered sodium alginate (SA) hydrogel dressing (SA‐MPS) is developed. MPS NSs, member ternary transition metal phosphorous chalcogenides (TMPCs), successfully prepared through ultrasonic‐assisted liquid phase exfoliation approach from bulk . These exhibit integrative functions sonosensitizers, Fenton‐like catalysts, glutathione (GSH) scavengers, phosphorus (P)/selenium (Se)‐containing nutrients. In vitro in vivo evaluations demonstrate SA‐MPS possesses excellent biocompatibility combined sonodynamic/chemodynamic therapy (SDT/CDT) tumors, with amplified reactive oxygen species (ROS) production. Additionally, it promotes skin regeneration wounds by supplying bioactive P/Se elements. Hence, such multifunctional without complex integration offers great potential suppressing while facilitating healing, making promising candidate care.

Язык: Английский

Процитировано

0
Efficacy and Safety of Photodynamic Therapy Sequential Dose-Reduction Concurrent Chemoradiotherapy in Locally Advanced Obstructive Esophageal Carcinoma: A Propensity Score Matching Analysis DOI Creative Commons
Ming Zhang,

Zhenhua Sun,

Gang Qiu

и другие.

Photodiagnosis and Photodynamic Therapy, Год журнала: 2025, Номер 52, С. 104509 - 104509

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Freestanding Hydrogen‐Bonded Organic Framework Membrane for Efficient Wound Healing DOI
Lingling Wu, Xue Yang,

Haonan Jia

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract Hydrogen‐bonded organic frameworks (HOFs) are emerging as multifunctional materials with exceptional biocompatibility, abundant active sites, and tunable porosity, which highly beneficial for advanced wound care. However, a significant challenge involves transforming pristine HOFs powders into lightweight, ultrathin, freestanding membranes compatible soft biological systems. Herein, the study successfully develops shape‐adaptive HOF‐based matrix (HMMs) using polymer‐assisted liquid‐air interface technique. The HMMs conform seamlessly to tissues of different sizes shapes, effectively stopping bleeding, provide high water‐vapor permeability. Notably, both in vitro vivo studies mice models demonstrated that these tissue‐conformable significantly accelerate healing by modulating inflammatory environment injured tissue promoting rapid re‐epithelialization. Furthermore, RNA‐seq analysis mechanistic revealed reduce inflammation facilitate transition from proliferative stage remodeling skin development. This work not only opens up new avenues care but also establishes foundation hybridizing polymers wide range potential applications.

Язык: Английский

Процитировано

4
An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes DOI

XinXin Ge,

Jiajun Hu,

Xiaoliang Qi

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Periodontal disease is a multifactorial, bacterially induced inflammatory disorder characterized by progressive destruction of periodontal tissues. Additionally, diabetes mellitus exacerbates periodontitis, resulting in expedited resorption bone. However, methods such as mechanical debridement, anti-inflammatory medications, and surgical approaches often fail to eradicate local infections inflammation, complicating the reconstruction tissue structures. Consequently, there an urgent need devise novel strategy for managing diabetic conditions. Here, multifunctional controlled-release drug delivery system (GOE1) developed encapsulating self-assembled nanoparticles (consisting chlorhexidine acetate epigallocatechin-3-gallate) into hydrogel matrix composed gelatin methacryloyl oxidized hyaluronic acid. In vitro experiments demonstrate that GOE1 possesses good antimicrobial, antioxidant properties, transgenic sequence genomics further illustrates IL-17-producing RAW 264.7 macrophages are critical mediating M1/M2 macrophage transition provide favorable immune microenvironment. addition, vivo reveal significantly ameliorates inflammation reduces loss alveolar bone reducing infiltration collagen destruction. Overall, offers promising therapeutic option periodontitis.

Язык: Английский

Процитировано

4