Advances in Hydrogel-Based Drug Delivery Systems

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 262 - 262

Published: April 13, 2024

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.

Language: Английский

---

Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

---

Nanotechnology based gas delivery system: a “green” strategy for cancer diagnosis and treatment

Theranostics, Journal Year: 2024, Volume and Issue: 14(14), P. 5461 - 5491

Published: Jan. 1, 2024

Gas therapy, a burgeoning clinical treatment modality, has garnered widespread attention to treat variety of pathologies in recent years. The advent nanoscale gas drug therapy represents novel therapeutic strategy, particularly demonstrating immense potential the realm oncology. This comprehensive review navigates landscape gases endowed with anti-cancer properties, including hydrogen (H

Language: Английский

---

Algae-inspired chitosan-pullulan-based multifunctional hydrogel for enhanced wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122751 - 122751

Published: Sept. 15, 2024

Language: Английский

---

Self‐Cascade of ROS/Glucose‐Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF‐κB Pathway

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, blood glucose levels, and recalcitrant bacterial infections. This is accompanied long‐term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, hybridized novel gold‐palladium (AuPd) nanoshell the injectable/injectable hydrogel system UiO/AuPd shells /BNN6/PEG@Gel (UAPsBP@Gel) developed. The capable acting as nitric oxide (NO) reactor utilizing synergistic therapy that harnesses NIR‐II light‐triggered photothermal effects controlled release NO gas for treatment to eradicate biofilm infections at different depths. AuPd nanoshells exhibits superoxide dismutase (SOD)‐, oxidase (GOx)‐, catalase (CAT)‐like activities, enabling self‐cascade process scavenging both reactive oxygen species (ROS) glucose. activity reshapes DUs microenvironment, switches on Nrf2/HO‐1 pathway inhibits NF‐κB pathway, promotes macrophage polarization toward anti‐inflammatory M2 phenotype, reduces resulting in efficient immunomodulation. In vitro / vivo results demonstrate UAPsBP@Gel can multifacetedly enhance epithelial rejuvenation through wound hemostasis, pro‐cellular migration vascularization. These highlight programmed therapeutic based UBAPsP@Gel tailored stages infected meet complex needs.

Language: Английский

---

An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Periodontal disease is a multifactorial, bacterially induced inflammatory disorder characterized by progressive destruction of periodontal tissues. Additionally, diabetes mellitus exacerbates periodontitis, resulting in expedited resorption bone. However, methods such as mechanical debridement, anti-inflammatory medications, and surgical approaches often fail to eradicate local infections inflammation, complicating the reconstruction tissue structures. Consequently, there an urgent need devise novel strategy for managing diabetic conditions. Here, multifunctional controlled-release drug delivery system (GOE1) developed encapsulating self-assembled nanoparticles (consisting chlorhexidine acetate epigallocatechin-3-gallate) into hydrogel matrix composed gelatin methacryloyl oxidized hyaluronic acid. In vitro experiments demonstrate that GOE1 possesses good antimicrobial, antioxidant properties, transgenic sequence genomics further illustrates IL-17-producing RAW 264.7 macrophages are critical mediating M1/M2 macrophage transition provide favorable immune microenvironment. addition, vivo reveal significantly ameliorates inflammation reduces loss alveolar bone reducing infiltration collagen destruction. Overall, offers promising therapeutic option periodontitis.

Language: Английский

---

Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity

ACS Nano, Journal Year: 2024, Volume and Issue: 18(23), P. 14877 - 14892

Published: May 29, 2024

Effective anticancer immunity depends on properly activating multiple stepwise events in the cancer-immunity cycle. An immunologically "cold" tumor microenvironment (TME) engenders immune evasion and refractoriness to conventional checkpoint blockade immunotherapy. Here, we combine nanoparticle formulations an situ formed hydrogel scaffold treat accessible tumors locally stimulate systemic against metastatic lesions. The nanoparticles encapsulate poly(ε-caprolactone)-derived cytotoxic chemotherapy adjuvant of Toll-like receptor 7/8 through a reactive oxygen species (ROS)-cleavable linker that can be self-activated by coassembled neighboring photosensitizer following near-infrared (NIR) laser irradiation. Further development results syringeable, NIR light-responsive, immunogenic (iGEL) implanted peritumorally deposited into surgical bed. Upon irradiation, generated ROS induces iGEL degradation bond cleavage polymer–drug conjugates, triggering cell death cascade cancer cells spontaneously releasing encapsulated agents rewire Notably, upon application preclinical models melanoma triple-negative breast cancer, which are aggressive refractory immunotherapy, durable remission established tumors, extends postsurgical tumor-free survival, inhibits burden. result this study is administrable for host improve immunotherapeutic efficacy with minimal off-target side effects.

Language: Английский

---

Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442

Published: Jan. 1, 2025

Language: Английский

---

A Hydrogel Engineered with Semiconductive MnPSe₃ Nanosheets as an Integrative Sonosensitizer/Fenton‐Like Catalyst/Nutrient for Melanoma Postoperative Care

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract The simultaneous inhibition of tumor recurrence and promotion wound healing are critical for patients undergoing melanoma surgery. However, the development an effective yet straightforward platform that meets comprehensive therapeutic requirements clinical postoperative care still remains a significant challenge. Herein, 2D semiconductive MnPSe 3 nanosheets (MPS NSs)‐engineered sodium alginate (SA) hydrogel dressing (SA‐MPS) is developed. MPS NSs, member ternary transition metal phosphorous chalcogenides (TMPCs), successfully prepared through ultrasonic‐assisted liquid phase exfoliation approach from bulk . These exhibit integrative functions sonosensitizers, Fenton‐like catalysts, glutathione (GSH) scavengers, phosphorus (P)/selenium (Se)‐containing nutrients. In vitro in vivo evaluations demonstrate SA‐MPS possesses excellent biocompatibility combined sonodynamic/chemodynamic therapy (SDT/CDT) tumors, with amplified reactive oxygen species (ROS) production. Additionally, it promotes skin regeneration wounds by supplying bioactive P/Se elements. Hence, such multifunctional without complex integration offers great potential suppressing while facilitating healing, making promising candidate care.

Language: Английский

---

Efficacy and Safety of Photodynamic Therapy Sequential Dose-Reduction Concurrent Chemoradiotherapy in Locally Advanced Obstructive Esophageal Carcinoma: A Propensity Score Matching Analysis

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: 52, P. 104509 - 104509

Published: Feb. 1, 2025

Language: Английский

---