Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(44), С. 24311 - 24324
Опубликована: Окт. 25, 2024
Salinization is recognized as a global problem, restricting agricultural production and sustainability. Targeting the salinity-induced oxidative stress, antioxidant treatment represents protective strategy to improve plant salt tolerance. Herein, we report V
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(15), С. 10478 - 10488
Опубликована: Апрель 5, 2024
During biomedical applications, nanozymes, exhibiting enzyme-like characteristics, inevitably come into contact with biological fluids in living systems, leading to the formation of a protein corona on their surface. Although it is acknowledged that molecular adsorption can influence catalytic activity there dearth understanding regarding impact nanozyme and its determinant factors. In order address this gap, we employed AuNR@Pt@PDDAC [PDDAC, poly(diallyldimethylammonium chloride)] nanorod (NR) as model multiple activities, including peroxidase, oxidase, catalase-mimetic investigate inhibitory effects activity. After identification major components plasma NR, observed spherical proteins fibrous induced distinct nanozymes. To elucidate underlying mechanism, uncovered adsorbed assembled surface forming networks (PNs). Notably, PNs derived from exhibited screen mesh-like structure smaller pore sizes compared those formed by proteins. This structural disparity resulted reduced efficiency for permeation substrate molecules, more robust inhibition These findings underscore significance shape crucial factor influencing revelation provides valuable insights rational design application nanozymes fields.
Язык: Английский
Процитировано
36
Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215937 - 215937
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
33
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
6
Advanced Science, Год журнала: 2024, Номер 11(38)
Опубликована: Авг. 9, 2024
Engineering multimetallic nanocatalysts with the entropy-mediated strategy to reduce reaction activation energy is regarded as an innovative and effective approach facilitate efficient heterogeneous catalysis. Accordingly, conformational entropy-driven high-entropy alloys (HEAs) are emerging a promising candidate settle catalytic efficiency limitations of nanozymes, attributed their versatile active site compositions synergistic effects. As proof nanozymes (HEzymes) concept, elaborate PdMoPtCoNi HEA nanowires (NWs) abundant sites tuned electronic structures, exhibiting peroxidase-mimicking activity comparable that natural horseradish peroxidase reported. Density functional theory calculations demonstrate enhanced electron abundance NWs near Fermi level (E
Язык: Английский
Процитировано
16
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132357 - 132357
Опубликована: Май 19, 2024
Язык: Английский
Процитировано
13
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Язык: Английский
Процитировано
12
Biomaterials, Год журнала: 2024, Номер 311, С. 122649 - 122649
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Abstract Oxidative damage, exacerbated by the excessive accumulation of reactive oxygen species (ROS), profoundly inhibits both crop growth and yield. Herein, a biocompatible nanozyme, calcium hexacyanoferrate nanoparticles (CaHCF NPs), targeting ROS is developed, to mitigate oxidative damage sequestrate heavy metal ions during plant growth. Uniquely, CaHCF NPs feature multifaced enzyme‐like activities, involving superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase, thiol ascorbate which enable them neutralize ROS. Furthermore, promote calcium‐cadmium exchange process, diminishing uptake metals. Importantly, 120 µg mL −1 alleviate inhibitory effects hydrogen peroxide cadmium chloride on Arabidopsis tomato. The activities SOD, POD, CAT increase 46.2%, 74.4%, 48.3%, respectively, meanwhile level rises 72.4% in under stress. Moreover, boost expression genes associated with antioxidation, detoxification, nutrient transport, stress resistance. These findings unveil significant potential nanoplatforms equipped nanozymes alleviating plants, not only regulate but also substantially ameliorate yield quality, heralding new era agricultural nanotechnology.
Язык: Английский
Процитировано
10
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112695 - 112695
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Trends in Chemistry, Год журнала: 2024, Номер 6(9), С. 540 - 555
Опубликована: Июль 30, 2024
Язык: Английский
Процитировано
9