Lactiplantibacillus plantarum GOLDGUT-HNU082 Alleviates CUMS-Induced Depressive-like Behaviors in Mice by Modulating the Gut Microbiota and Neurotransmitter Levels

Foods, Год журнала: 2025, Номер 14(5), С. 813 - 813

Опубликована: Фев. 26, 2025

Emerging evidence links depressive disorders to the gut microbiota via gut-brain axis. Probiotics, which are microorganisms that modulate microbiota, have shown promising results in alleviating depression and increasingly recognized as functional food components with potential health benefits. This study examines effects of Lactiplantibacillus plantarum GOLDGUT-HNU082 (Lp082), a probiotic strain applications foods, on chronic unpredictable mild stress (CUMS)-induced mice. Behavioral tests, measurements neurotransmitters inflammatory cytokines serum colon tissue, metagenomic sequencing were used investigate mechanisms. The demonstrated Lp082 significantly alleviated depressive-like behaviors CUMS mice, restored balance key like serotonin (5-HT), reduced levels TNF-α, enhanced brain neuroplasticity by promoting hippocampal neurogenesis. Additionally, altered composition mice promoted growth Bifidobacterium, improving metabolic pathways related neurotransmitter synthesis. These findings indicate Lp082, ingredient, alleviates reshaping offering new insights into use probiotics foods for mental management.

Язык: Английский

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RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 28, 2024

Язык: Английский

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Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

Journal of Neurochemistry, Год журнала: 2025, Номер 169(1)

Опубликована: Янв. 1, 2025

Epitranscriptomic regulation of cell functions involves multiple post-transcriptional chemical modifications coding and non-coding RNA that are increasingly recognized in studying human brain disorders. Although rodent models presently widely used neuroepitranscriptomic research, the zebrafish (Danio rerio) has emerged as a useful promising alternative model species. Mounting evidence supports importance CNS function, providing additional insights into epitranscriptomic mechanisms underlying wide range Here, we discuss recent data on role regulation, with particular focus models, well evaluate current problems, challenges, future directions research this field molecular neurochemistry.

Язык: Английский

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M6A Demethylase ALKBH5 in Human Diseases: From Structure to Mechanisms

Biomolecules, Год журнала: 2025, Номер 15(2), С. 157 - 157

Опубликована: Янв. 21, 2025

N6-methyladenosine (m6A) is the most abundant, dynamically reversible, and evolutionarily conserved internal chemical modification in eukaryotic RNA. It emerging as critical for regulating gene expression at post-transcriptional level by affecting RNA metabolism through, example, pre-mRNA processing, mRNA decay, translation. ALKBH5 has recently been identified an endogenous m6A demethylase implicated a multitude of biological processes. This review provides overview structural functional characteristics involvement diverse human diseases, including metabolic, immune, reproductive, nervous system disorders, well development inhibitors. In summation, this highlights current understanding structure, functions, detailed mechanisms various physiological pathological processes valuable insights clinical applications foundational research within related fields.

Язык: Английский

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The RNA Demethyltransferase FTO Regulates Ferroptosis in Major Depressive Disorder

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1075 - 1075

Опубликована: Янв. 26, 2025

Major depressive disorder (MDD) is a widespread and severe mental health condition characterized by persistent low mood loss of interest. Emerging evidence suggests that ferroptosis, an iron-dependent form cell death, epigenetic dysregulation contribute to the pathogenesis MDD. This study investigates role RNA demethylase FTO autophagy regulator BECN1 in ferroptosis their regulation active compound ginsenoside Rb1 (GRb1) as potential antidepressant strategy. Hippocampal tissues from postmortem MDD patient brains mice with chronic restraint stress (CRS)-induced depression were analyzed. Ferroptosis was evaluated analyzing levels markers such glutathione (GSH) malondialdehyde (MDA). GRb1 administered CRS model gavage explore its effects on ferroptosis-related pathways. The results showed expression reduced hippocampal patients mice, promoting via disruption antioxidant system. Moreover, treatment increased expression, modulated m6A methylation, restored balance, inhibited mice. These findings reveal novel mechanism highlight promising agent for treating through targeting

Язык: Английский

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Exposure to polystyrene nanoplastics causes anxiety and depressive-like behavior and down-regulates EAAT2 expression in mice

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Язык: Английский

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Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 14, 2025

Astrocytes are closely linked to depression, and the prefrontal cortex (PFC) is an important brain region involved in major depressive disorder (MDD). However, underlying mechanism by which astrocytes within PFC contribute MDD remains unclear. Using single-nucleus RNA sequencing analyses, we show a significant reduction attenuated pleiotrophin-protein tyrosine phosphatase receptor type Z1 (PTN-PTPRZ1) signaling astrocyte-to-excitatory neuron communication of male patients. We find reduced PTN dorsomedial mice with depression induced chronic restraint social defeat stress. Knockdown astrocytic induces depression-related responses, reversed exogenous supplementation or overexpression PTN. The antidepressant effects exerted require interaction PTPRZ1 excitatory neurons, PTN-PTPRZ1 activates AKT pathway regulate responses. Our findings indicate PTN-PTPRZ1-AKT may be potential therapeutic target for MDD. but mechanisms remain Here, authors that pleiotrophin contributes depression-like phenotype mice.

Язык: Английский

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Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2774 - 2774

Опубликована: Март 19, 2025

Anxiety is a physiological, emotional response that anticipates distal threats. When kept under control, anxiety beneficial response, helping animals to maintain heightened attention in environments with potential dangers. However, an overestimation of threats can lead excessive expression that, humans, may evolve into disorders. Pharmacological treatments show variable efficacy among patients, highlighting the need for more efforts better understand pathogenesis Mounting evidence suggests astrocytes, type glial cells, are active partners neurons brain circuits and regulation behaviors both physiological pathological conditions. In this review, I summarize current literature on role astrocytes from different regions modulating anxious states, goal exploring novel cerebral mechanisms identify innovative therapeutic targets treatment

Язык: Английский

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Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 416 - 416

Опубликована: Апрель 19, 2025

Background: Increasing evidence shows that HCY plays an important role in stress-induced cognitive dysfunction, and significantly promotes the decline of function. Stress has been reported to cause elevated hippocampus mice. Cognitive flexibility refers ability individuals quickly adjust their neurobehavioral strategies different situations or solve tasks. Aims: This study aims explore impairment induced by stress its possible regulatory mechanism. Methods: First, we examined changes protein mRNA levels effector molecule, PIN1, during The results show can a mice lead increase PIN1. Moreover, through use vitro experiments, found could induce PIN1 expression neurons. Further vivo experiments were used investigate effect VitB on evaluated therapeutic flexibility. decreased plasma hippocampus, alleviated flexibility, reduced Conclusions: These suggest be inhibited regulating content HCY. Collectively, our findings highlight aimed at improving treatment for impairments

Язык: Английский

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Exosome‐Functionalized Self‐Carrier Enzyme‐Like/Drug With Triple Amplified Anti‐Oxidative Stress for Synergistic Depression Therapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract Depression, a severe disorder affecting both physical and mental health, is commonly treated with first‐line antidepressants, which often exhibit limited efficacy due to poor penetration of the blood‐brain barrier (BBB) significant side effects, thus requiring exploitation biocompatible effective treatments. Recent studies suggest that depression closely linked an imbalance in oxidative stress subsequent inflammatory responses. Antioxidant therapies targeting are therefore emerging as promising strategies. In this study, exosome‐functionalized geniposide (GEN) self‐carried Prussian blue (PB) nanotherapeutic approach fabricated realize efficient BBB for synergistic therapy. The porous PB carrier possesses multi‐enzyme capabilities, can effectively scavenge accumulated ROS, protecting slightly acidic environment released GEN from oxidation, subsequently works simultaneously activate Nrf2‐ARE pathway, enhancing body's defense mechanisms synergistically. triple‐amplified anti‐oxidant strategy nanomaterial shown mitigate microglial activation reduction neuroplasticity, ultimately alleviating pathological markers depression. Overall, constructed nanomaterials underscore therapeutic potential anti‐oxidative removal ROS pathway treatment

Язык: Английский

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