Unveiling GATOR2 Function: Novel Insights from Drosophila Research DOI Creative Commons
Lucia Bettedi, Yingbiao Zhang, Shuhua Yang

и другие.

Cells, Год журнала: 2024, Номер 13(21), С. 1795 - 1795

Опубликована: Окт. 30, 2024

The multiprotein Target of Rapamycin (TOR) Complex 1 (TORC1) is a serine/threonine kinase that stimulates anabolic metabolism and suppresses catabolism. Deregulation TORC1 implicated in various human pathologies, including cancer, epilepsy, neurodegenerative disorders. Gap Activity Towards Rags (GATOR) complex contains two subcomplexes: GATOR1, which inhibits activity; GATOR2, counteracts GATOR1s function. Structural biochemical studies have elucidated how GATOR1 regulates activity by acting as GTPase activating protein for Rag GTPase. However, while cryogenic electron microscopy has determined the structure multi-protein GATOR2 conserved from yeast to humans, remains unclear. Here, we describe recent whole-animal Drosophila yielded novel insights into function, identifying role subunit WDR59, redefining core proteins sufficient activity, defining TORC1-independent regulation lysosomal autophagic endomembrane system. Additionally, characterization methionine receptor acts through suggests an attractive model evolution species-specific nutrient sensors. Research on function highlights genetic models can be used dissect intracellular signaling pathways identify tissue-specific functions functional redundancies may missed confined rapidly proliferating cell lines.

Язык: Английский

Interplay of RNA-binding proteins controls germ cell development in zebrafish DOI

De‐Li Shi

Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2024, Номер 51(9), С. 889 - 899

Опубликована: Июль 4, 2024

Язык: Английский

Процитировано

1
Zebrafish as a model system for studying reproductive diseases DOI Creative Commons

Wenwen Zha,

Weitao Hu,

Chenkai Ge

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Дек. 23, 2024

Reproductive system diseases have become a major health challenge facing humans, so extensive investigations are needed to understand their complex pathogenesis and summarize effective treatments. In the study of reproductive diseases, mice most commonly used animal model. However, cost time required establish mouse models high. The existing zebrafish model can solve this problem well. Zebrafish is an with great application prospects has lots advantages, including high degree genetic conservation short cycle, transparent embryos, rapid growth, providing unique opportunities for high-throughput drug screening identification potential Researchers successfully chemical induction, physical damage, gene editing technology, etc., induce damage in biological processes related its diseases. Therefore, review, main advantages summarized, pathological mechanisms as disease clarified, new perspectives valuable insights provided treatment human literature data cited review all from PubMed, covering important research results on past 10 years.

Язык: Английский

Процитировано

0
Identification, expression, and function analysis of Rbpms2 splicing variants in Japanese flounder gonad DOI
Liu Cui, Longsheng Zhang,

Xia You

и другие.

General and Comparative Endocrinology, Год журнала: 2024, Номер unknown, С. 114628 - 114628

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Unveiling GATOR2 Function: Novel Insights from Drosophila Research DOI Creative Commons
Lucia Bettedi, Yingbiao Zhang, Shuhua Yang

и другие.

Cells, Год журнала: 2024, Номер 13(21), С. 1795 - 1795

Опубликована: Окт. 30, 2024

The multiprotein Target of Rapamycin (TOR) Complex 1 (TORC1) is a serine/threonine kinase that stimulates anabolic metabolism and suppresses catabolism. Deregulation TORC1 implicated in various human pathologies, including cancer, epilepsy, neurodegenerative disorders. Gap Activity Towards Rags (GATOR) complex contains two subcomplexes: GATOR1, which inhibits activity; GATOR2, counteracts GATOR1s function. Structural biochemical studies have elucidated how GATOR1 regulates activity by acting as GTPase activating protein for Rag GTPase. However, while cryogenic electron microscopy has determined the structure multi-protein GATOR2 conserved from yeast to humans, remains unclear. Here, we describe recent whole-animal Drosophila yielded novel insights into function, identifying role subunit WDR59, redefining core proteins sufficient activity, defining TORC1-independent regulation lysosomal autophagic endomembrane system. Additionally, characterization methionine receptor acts through suggests an attractive model evolution species-specific nutrient sensors. Research on function highlights genetic models can be used dissect intracellular signaling pathways identify tissue-specific functions functional redundancies may missed confined rapidly proliferating cell lines.

Язык: Английский

Процитировано

0