Ultrasound-activated mechanochemical reactions for controllable biomedical applications
Maocheng Zuo,
Rong Xiao,
Fangxue Du
и другие.
Smart Materials in Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Effects of blood-brain barrier opening using ultrasound on tauopathies: A systematic review
Journal of Controlled Release,
Год журнала:
2025,
Номер
379, С. 1029 - 1044
Опубликована: Фев. 4, 2025
Язык: Английский
Low intensity trans-spinal focused ultrasound reduces mechanical sensitivity and suppresses spinal microglia activation in rats with chronic constriction injury
Bioelectronic Medicine,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 30, 2025
Abstract
Low
intensity,
trans-spinal
focused
ultrasound
(tsFUS)
is
a
noninvasive
neuromodulation
approach
that
has
been
shown
to
modulate
spinal
circuit
excitability
in
healthy
rats.
Here,
we
evaluated
the
potential
of
tsFUS
for
alleviating
neuropathic
pain
by
testing
it
chronic
constriction
injury
(CCI)
model.
Male
rats
underwent
CCI
left
sciatic
nerve
and
then
received
(2
kHz
pulse
repetition
frequency;
40%
duty
cycle)
or
sham
stimulation,
targeted
at
segment
level
L5
3
min
daily
over
three
days.
As
expected,
causes
significant
reduction
von
Frey
Threshold
(vFT),
measure
mechanical
sensitivity.
We
found
treatment
associated
with
increased
vFT
compared
sham;
this
increase
persists
beyond
duration
treatment,
through
days
4
23
post-CCI.
In
cords
tsFUS-treated
animals,
counts
microglia
(Iba1
+
cells)
activated,
pro-inflammatory
/CD86
cells),
are
reduced
sham-treated
animals.
This
limited
insonified
side
cord,
ipsilateral
CCI.
These
findings
suggest
may
be
promising
early
stages,
possibly
attenuating
development
microglial-driven
inflammation.
Язык: Английский
Advances in brain computer interface for amyotrophic lateral sclerosis communication
Brain‐X,
Год журнала:
2025,
Номер
3(1)
Опубликована: Март 1, 2025
Abstract
Amyotrophic
lateral
sclerosis
(ALS)
is
a
progressive
neurodegenerative
disease
that
often
results
in
the
loss
of
speech,
creating
significant
communication
barriers.
Brain–computer
interfaces
(BCIs)
provide
transformative
solution
for
restoring
and
enhancing
quality
life
ALS
individuals.
Recent
advances
implantable
electrocorticographic
systems
have
demonstrated
feasibility
synthesizing
intelligible
speech
directly
from
neural
activity.
By
recording
high‐resolution
signals
motor,
premotor,
somatosensory
cortices
with
decoding
algorithms,
these
can
transform
patterns
into
acoustic
features
providing
natural
intuitive
pathways
Non‐invasive
electroencephalography,
while
lacking
spatial
resolution
systems,
offers
safer
alternative
high
temporal
capturing
speech‐related
dynamics.
When
combined
robust
feature
extraction
techniques,
such
as
common
pattern
time‐frequency
analyses,
well
multimodal
integration
functional
near‐infrared
spectroscopy
or
electromyography,
it
effectively
enhances
accuracy
system
robustness.
Despite
progress,
challenges
remain,
including
user
variability,
BCI
illiteracy,
impact
fatigue
on
performance.
Personalized
models,
adaptive
secure
frameworks
brain
data
privacy
are
essential
addressing
limitations,
enabling
BCIs
to
enhance
accessibility
reliability.
Advancing
technologies
methodologies
holds
immense
promise
independence
bridging
gap
individuals
ALS.
Future
research
could
focus
long‐term
clinical
studies
evaluate
stability
effectiveness
development
more
unobtrusive
paradigms.
Язык: Английский
Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates
Опубликована: Апрель 16, 2025
Abstract
Objective
Utah
arrays
are
widely
used
in
both
humans
and
non-human
primates
(NHPs)
for
intracortical
brain-computer
interfaces
(BCIs),
primarily
detecting
electrical
signals
from
cortical
tissue
to
decode
motor
commands.
Recently,
these
have
also
been
applied
deliver
stimulation
aimed
at
restoring
sensory
functions.
A
key
challenge
limiting
their
longevity
is
the
micromotion
between
array
tissue,
which
may
induce
mechanical
strain
surrounding
contribute
performance
decline.
This
strain,
due
mismatch,
can
exacerbate
glial
scarring
around
implant,
reducing
efficacy
of
recording
neuronal
activity
delivering
stimulation.
Approach
To
investigate
this,
we
employed
a
finite
element
model
(FEM)
predict
strains
resulting
micromotion.
Main
Results
Our
findings
indicated
that
profiles
edge
corner
electrodes
were
greater
than
those
interior
shanks,
affecting
maximum
average
within
50
µm
electrode
tip.
We
then
correlated
predicted
with
in-vivo
metrics.
found
negative
correlations
1
kHz
impedance
human
NHP
area
V4
1-mo,
1-yr,
2-yrs
post-implantation.
In
arrays,
peak-to-peak
waveform
voltage
(PTPV)
signal-to-noise
ratio
(SNR)
spontaneous
negatively
strain.
Conversely,
observed
positive
correlation
evoked
SNR
multi-unit
arrays.
Significance
study
establishes
spatial
dependence
correlates
Язык: Английский
Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 17, 2024
Abstract
Neuromodulation
technologies
have
gained
considerable
attention
for
their
clinical
potential
in
treating
neurological
disorders
and
advancing
cognition
research.
However,
traditional
methods
like
electrical
stimulation
optogenetics
face
technical
biological
challenges
that
limit
therapeutic
research
applications.
A
promising
alternative,
photoelectric
neurostimulation,
uses
near‐infrared
light
to
generate
pulses
thus
enables
of
neuronal
activity
without
genetic
alterations.
This
study
explores
various
design
strategies
enhance
with
minimally
invasive,
ultrasmall,
untethered
carbon
electrodes.
Employing
a
multiphoton
laser
as
the
(NIR)
source,
benchtop
experiments
are
conducted
using
three‐electrode
setup
chronopotentiometry
record
photo‐stimulated
voltage.
In
vivo
evaluations
utilize
Thy1‐GCaMP6s
mice
acutely
implanted
ultrasmall
Results
highlighted
beneficial
effects
high
duty‐cycle
scanning
photovoltaic
polymer
interfaces
on
voltages
by
electrode.
Additionally,
carbon‐based
diamond
electrodes
demonstrated
application
precise
chemical
delivery
loading
mesoporous
silica
nanoparticles
(SNPs)
co‐deposited
polyethylenedioxythiophene
(PEDOT).
Together,
these
findings
utilizing
underscore
its
immense
next
generation
neurostimulation
technology.
Язык: Английский
Jingle Cell Rock: Steering Cellular Activity With Low-Intensity Pulsed Ultrasound (LIPUS) to Engineer Functional Tissues in Regenerative Medicine
Ultrasound in Medicine & Biology,
Год журнала:
2024,
Номер
50(12), С. 1973 - 1986
Опубликована: Сен. 16, 2024
Acoustic
manipulation
or
perturbation
of
biological
soft
matter
has
emerged
as
a
promising
clinical
treatment
for
number
applications
within
regenerative
medicine,
ranging
from
bone
fracture
repair
to
neuromodulation.
The
potential
ultrasound
(US)
endures
in
imparting
mechanical
stimuli
that
are
able
trigger
cascade
molecular
signals
unscathed
cells.
Particularly,
low-intensity
pulsed
(LIPUS)
been
associated
with
bio-effects
such
activation
specific
cellular
pathways
and
alteration
cell
morphology
gene
expression,
the
extent
which
can
be
modulated
by
fine
tuning
LIPUS
parameters
including
intensity,
frequency
exposure
time.
Although
mechanisms
underlying
not
yet
fully
elucidated,
studies
clearly
define
modulation
ultrasonic
means
guide
differentiation
set
stem
cells
towards
adult
differentiated
types.
Herein,
we
outline
medicine
vivo
vitro
have
confirmed
unbounded
this
platform.
We
highlight
latest
developments
aimed
at
investigating
physical
action
LIPUS,
outlining
most
recent
efforts
using
technology
aid
tissue
engineering
strategies
repairing
modelling
diseases.
Ultimately,
detail
tissue-specific
harnessing
stimuli,
offering
insights
over
new
constructs
therapeutic
modalities.
Overall,
aim
lay
foundation
deeper
understanding
governing
LIPUS-based
therapy,
inform
development
safer
more
effective
regeneration
field
medicine.
Язык: Английский
Charting the neuroscience of interpersonal trust: A bibliographic literature review
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
unknown, С. 105930 - 105930
Опубликована: Окт. 1, 2024
Язык: Английский
Low-Intensity Pulsed Ultrasound Dynamically Modulates the Migration of BV2 Microglia
Ultrasound in Medicine & Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Dynamic changes in the structure and function of brain mural cells around chronically implanted microelectrodes
Steven M. Wellman,
Adam M. Forrest,
Madeline M. Douglas
и другие.
Biomaterials,
Год журнала:
2024,
Номер
315, С. 122963 - 122963
Опубликована: Ноя. 12, 2024
Integration
of
neural
interfaces
with
minimal
tissue
disruption
in
the
brain
is
ideal
to
develop
robust
tools
that
can
address
essential
neuroscience
questions
and
combat
neurological
disorders.
However,
implantation
intracortical
devices
provokes
severe
inflammation
within
brain,
which
requires
a
high
metabolic
demand
support
complex
series
cellular
events
mediating
degeneration
wound
healing.
Pericytes,
peri-vascular
cells
involved
blood-brain
barrier
maintenance,
vascular
permeability,
waste
clearance,
angiogenesis,
have
recently
been
implicated
as
potential
perpetuators
neurodegeneration
injury
disease.
While
intimate
relationship
between
pericytes
cortical
microvasculature
explored
other
disease
states,
their
behavior
following
microelectrode
implantation,
responsible
for
direct
blood
vessel
dysfunction,
currently
unknown.
Using
two-photon
microscopy
we
observed
dynamic
changes
structure
function
during
array
over
4-week
period.
Pericytes
respond
electrode
insertion
through
transient
increases
intracellular
calcium
underlying
constriction
capillary
vessels.
Within
days
initial
insertion,
an
influx
new,
proliferating
contribute
new
formation.
Additionally,
discovered
potentially
novel
population
reactive
immune
close
proximity
electrode-tissue
interface
actively
engaging
encapsulation
array.
Finally,
determined
pericyte
be
modulated
by
microstimulation
amplitude-
frequency-dependent
manner.
This
study
provides
perspective
on
biological
sequelae
occurring
at
will
foster
avenues
research
consideration
lead
development
more
advanced
therapeutic
interventions
towards
improving
biocompatibility
technology.
Язык: Английский