Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Prussian Blue and Its Analogues for Commercializing Fast-Charging Sodium/Potassium-Ion Batteries

ACS Energy Letters, Год журнала: 2025, Номер unknown, С. 750 - 778

Опубликована: Янв. 13, 2025

Fast-charging technology, which reduces charging time and enhances convenience, is attracting attention. Sodium-ion batteries (SIBs) potassium-ion (PIBs) are emerging as viable alternatives to lithium-ion (LIBs) due their abundant resources low cost. However, during fast discharging, the crystal structures of cathode materials in SIBs/PIBs can be damaged, negatively impacting performance, lifespan, capacity. To address this, there a need explore electrode with ultrahigh rate capabilities. Prussian Blue its analogues (PB PBAs) have shown great potential for both SIBs PIBs unique excellent electrochemical properties. This Review examines use PBAs PIBs, focusing on fast-charging (rate) performance commercialization potential. Through systematic analysis discussion, we hope provide practical guidance developing contributing advancement widespread adoption green energy technologies.

Язык: Английский

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Kinetic Profiling of Oxidoreductase-Mimicking Nanozymes: Impact of Multiple Activities, Chemical Transformations, and Colloidal Stability

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

In contrast to homogeneous enzyme catalysis, nanozymes are nanosized heterogeneous catalysts that perform reactions on a rigid surface. This fundamental difference between enzymes and is often overlooked in kinetic studies practical applications. this article, using 14 of various compositions (core@shell, metal-organic frameworks, metal, metal oxide nanoparticles), we systematically demonstrate nontypical features nanozymes, such as multiple catalytic activities, chemical transformations, aggregation, need be considered nanozyme catalysis. Ignoring these results the inaccurate quantification activity. Neglecting activities led six-time underestimation Mn

Язык: Английский

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Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139535 - 139535

Опубликована: Янв. 5, 2025

Язык: Английский

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Investigation into recent advanced strategies of reactive oxygen species-mediated therapy based on Prussian blue: Conceptualization and prospect

Bioactive Materials, Год журнала: 2025, Номер 48, С. 71 - 99

Опубликована: Фев. 13, 2025

Язык: Английский

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Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within joint cavity. This study introduces a co‐delivery system of integrating nanoenzymes gene therapeutics sequentially modified with guanidinium‐based polymers membranes to achieve synergistic therapeutic effects. is named MACP siTNF‐α nanoparticles (NPs). are designed for targeted delivery inflamed site, where they preferentially internalized by M1‐type macrophages efficiently evade lysosomal degradation. Subsequently, operates via self‐sustaining positive feedback drug release mechanism. biomimetic nanoplatform reduces reactive oxygen species (ROS) levels prevents glutathione (GSH) depletion. GSH degrades small interfering RNA (siRNA) expose Prussian blue (PB) nanoenzymes, which effectively scavenge ROS restore levels. loop significantly enhances silencing capability scavenging efficiency system. In summary, NPs can reverse ecological niche soils through dual mechanism inhibiting expression tumor necrosis factor‐alpha (TNF‐α) upstream pathway response, eliminating ROS, thus realizing efficient treatment RA.

Язык: Английский

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Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 3, 2025

Abstract Immunotherapy holds notable progress in the treatment of cancer. However, clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as revolutionary tool surmount these obstacles amplify potency immunotherapeutic agents. Prussian blue nanoparticles (PBNPs) exhibit multi-dimensional immune function cancer immunotherapy, including acting nanocarrier deliver agents, photothermal agent improve efficacy immunotherapy through therapy, nanozyme regulate tumor microenvironment, an iron donor induce events related ferroptosis tumor-associated macrophages polarization. This review focuses on advances applications PBNPs immunotherapy. First, biomedical functions are introduced. Then, based PBNPs, we systematically reviewed multidimensional application Finally, challenges future developments PBNPs-based highlighted. Graphical abstract

Язык: Английский

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A Single H₂S-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive environments, such as hyperglycemia, bacterial infection, impaired angiogenesis. However, current are complicated need on-demand sequential release synergy of multicomponents. Herein, H2S-releasing cascade nanozyme (FeS@Au), which is composed ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), developed single component regulate glucose level, eliminate promote angiogenesis, achieving for diabetic treatment. The oxidase-like activity AuNC catalyzes into gluconic acid H2O2, not only lowers the local level but also decreases pH increases H2O2 boost peroxidase-like FeSNP generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, H2S acidified environment upregulate hypoxia-inducible factor-1 enhance vascularization through upregulating expression vascular endothelial growth factor (VEGF) other angiogenesis-related genes, reducing damage cells caused by excessive ROS produced nanozyme. In full-thickness MRSA-infected rat model, FeS@Au significantly eliminates bacteria, enhances promotes collagen deposition, accelerates healing. This work with H2S-release interventions, providing versatile strategy extensive tissue diabetes.

Язык: Английский

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A smartphone sensing colorimetric detection of ascorbic acid in fruit samples based on Cu2Fe(CN)6@PVP nanozyme

Talanta, Год журнала: 2025, Номер unknown, С. 128152 - 128152

Опубликована: Апрель 1, 2025

Язык: Английский

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Exosome‐Functionalized Self‐Carrier Enzyme‐Like/Drug With Triple Amplified Anti‐Oxidative Stress for Synergistic Depression Therapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract Depression, a severe disorder affecting both physical and mental health, is commonly treated with first‐line antidepressants, which often exhibit limited efficacy due to poor penetration of the blood‐brain barrier (BBB) significant side effects, thus requiring exploitation biocompatible effective treatments. Recent studies suggest that depression closely linked an imbalance in oxidative stress subsequent inflammatory responses. Antioxidant therapies targeting are therefore emerging as promising strategies. In this study, exosome‐functionalized geniposide (GEN) self‐carried Prussian blue (PB) nanotherapeutic approach fabricated realize efficient BBB for synergistic therapy. The porous PB carrier possesses multi‐enzyme capabilities, can effectively scavenge accumulated ROS, protecting slightly acidic environment released GEN from oxidation, subsequently works simultaneously activate Nrf2‐ARE pathway, enhancing body's defense mechanisms synergistically. triple‐amplified anti‐oxidant strategy nanomaterial shown mitigate microglial activation reduction neuroplasticity, ultimately alleviating pathological markers depression. Overall, constructed nanomaterials underscore therapeutic potential anti‐oxidative removal ROS pathway treatment

Язык: Английский

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