In Vivo Functional Properties of Dairy Bacteria

Microorganisms, Год журнала: 2023, Номер 11(7), С. 1787 - 1787

Опубликована: Июль 11, 2023

This literature review aimed to collect investigations on the in vivo evidence for bacteria associated with fermented dairy foods behave as probiotics beneficial effects prevention and treatment of various diseases. All main bacterial groups commonly present high numbers milks or cheeses were taken into account, namely starter lactic acid (SLAB) Lactobacillus delbrueckii subsp. bulgaricus lactis, L. helveticus, Lactococcus Streptococcus thermophilus, non-starter LAB (NSLAB) Lacticaseibacillus spp., Lactiplantibacillus plantarum, propionibacteria, other less frequently encountered species. Only studies regarding strains proven origin considered. Studies animal models clinical showed that ameliorate symptoms inflammatory bowel disease (IBD), mucositis, metabolic syndrome, aging oxidative stress, cancer, bone diseases, atopic dermatitis, allergies, infections damage caused by pollutants, mild depression. Immunomodulation changes intestinal microbiota mechanisms most often involved observed effects. The results considered indicated milk products are a rich source should be further exploited advantage human health.

Язык: Английский

---

The role of probiotics in improving food safety; detoxification of heavy metals and chemicals

Toxin Reviews, Год журнала: 2023, Номер 43(1), С. 63 - 91

Опубликована: Ноя. 22, 2023

Various studies have shown that different types of probiotics as healthy gut microbes, in addition to having beneficial effects on the host's health, an excellent ability eliminate and neutralize chemical toxins unwanted substances foods, ultimately, they can increase food safety. The purpose present review was comprehensively discuss role improving safety terms adsorption/detoxification heavy metals, pesticides, anti-parasitic drug residues, antibiotic oxidants, synthetic/unauthorized additives (e.g. nitrite nitrate, acrylamide, heterocyclic amines, polycyclic aromatic hydrocarbons, acetamide, oxalate) products. Some recent examples neutralizing agents body after consuming contaminated also been mentioned. This shows potential inactivate detoxify various biological synthetic compounds foods host consumption.

Язык: Английский

---

Postbiotic of Pediococcus acidilactici GQ01, a Novel Probiotic Strain Isolated from Natural Fermented Wolfberry, Attenuates Hyperuricaemia in Mice through Modulating Uric Acid Metabolism and Gut Microbiota

Foods, Год журнала: 2024, Номер 13(6), С. 923 - 923

Опубликована: Март 18, 2024

Hyperuricaemia (HUA) is a disorder of purine metabolism, which manifests itself as an increase in uric acid production and decrease excretion, well change the structure intestinal microbiota. Most drugs currently used to treat HUA have significant side effects, it essential find treatment for that free effects. In this study, novel strain, Pediococcus acidilactici GQ01, was screened from natural fermented wolfberry. The effects both live bacteria GQ01 its heat-killed G1PB postbiotic on were investigated. results showed probiotic postbiotics could effectively blood acid, creatinine, urea nitrogen levels mice model. P. more effective inhibiting ADA activity, while XOD activity. Meanwhile, able ameliorate liver kidney tissue injury, upregulate expression ABCG2 gene liver, downregulate protein URAT1 GLUT9 kidney, therefore reduce value by decreasing reabsorption increasing excretion acid. Additionally, probiotics regulate microbiota mice, so bring dysfunctional composition back normal. Furthermore, can acetic propionic butyric tract, improve function, maintain healthy homeostatic state tract. summary, may be developed functional food or drug materials capable treating HUA.

Язык: Английский

---

Biosorption characteristics and Caco-2 cells detoxification evaluations of lead(II) using exopolysaccharides produced by Paenibacillus bovis BD3526 in a wheat-bran medium

Environmental Technology & Innovation, Год журнала: 2025, Номер unknown, С. 104059 - 104059

Опубликована: Янв. 1, 2025

Язык: Английский

---

The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies

Health Science Reports, Год журнала: 2025, Номер 8(3)

Опубликована: Март 1, 2025

ABSTRACT Background and Aims Probiotics usually have beneficial effects on the absorption of trace elements detoxification toxic metals in human. Hence, aim systematic review was to evaluate various aspects effect combination probiotics heavy human clinical trial studies. Methods Nine databases were searched for trials up June 2024 investigating metal exposure humans. Two reviewers independently screened records extracted data study characteristics, interventions, outcomes, results. Risk bias assessed. Results The analysis included 31 with a total 4,611 participants, focusing probiotics, prebiotics, synbiotics. Among trials, 23 investigated five looked at three explored synbiotics, probiotic doses ranging from 10 7 2.5 × CFU/day. indicated that combined zinc significantly reduced time resolution vomiting diarrhea compared alone, improved treatment efficacy antibiotic‐associated linked pneumonia, shortened hospital stays relative alone. did not show significant blood parameters placebo; however, prebiotic galactooligosaccharides enhanced iron women children. addition bismuth quadruple therapy improve Helicobacter pylori eradication rates but side like vomiting. One reported decrease levels pregnant due no similar observed Conclusions are one new methods employed or eliminate adverse body. Although many studies metals, there is still need more in‐depth extensive

Язык: Английский

---

Novel native probiotics with protective effects against nickel-induced kidney injury: a strategy for heavy metal toxicity

BioMetals, Год журнала: 2025, Номер unknown

Опубликована: Апрель 5, 2025

Язык: Английский

---

Capsular Polysaccharides Are Crucial for the Biosorption of Aqueous Pb(II) Ions by Limosilactobacillus fermentum B44 In Vitro

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

---

Pediococcus acidilactici reduces tau pathology and ameliorates behavioral deficits in models of neurodegenerative disorders

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 30, 2024

Abstract Background Alzheimer’s disease (AD), affecting many elders worldwide, is characterized by A-beta and tau-related cognitive decline. Accumulating evidence suggests that brain iron accumulation an important characteristic of AD. However, the function mechanism iron-mediated gut-brain axis on AD still unclear. Methods A Caenorhabditis elegans model with tau-overexpression a high-Fe diet mouse impairment was used for probiotic evaluation. With use qPCR, immunoblotting, regulated differential expression markers related transporting genes determined. Colorimetric kits, IHC staining, immunofluorescence have been performed to explore development links accumulation. Results In present study, evaluation in which impairment, higher A-beta, tau phosphorylated (p)-tau expression, dysfunctional phosphate distribution were observed. Considering close crosstalk between intestine brain, probiotics then employed delay process HFe model. Pediococcus acidilactici (PA), but not Bacillus subtilis (BN) administration HFe-fed mice reduced accumulation, enhanced global alkaline phosphatase (AP) activity, accelerated dephosphorylation, lowered levels increased urate production. addition, because PA behavior fed mice, we transgenic over-expressed human p-tau model, worms became more active longer lived than E.coli worms, as well down-regulated. These results suggest influences risk proteins various metabolites. Furthermore, shown reverse tau-induced pathogenesis via transporters AP-urate interaction. Conclusions studies demonstrate mediator protein reduction, neurodegenerative both iron-overload mice. Finally, our provide candidates AP modulation strategies preventive tools promoting health.

Язык: Английский

---

Pangenome reconstruction of Lactobacillaceae metabolism predicts species-specific metabolic traits

mSystems, Год журнала: 2024, Номер 9(7)

Опубликована: Июнь 26, 2024

ABSTRACT Strains across the Lactobacillaceae family form basis for a trillion-dollar industry. Our understanding of genomic their key traits is fragmented, however, including metabolism that foundational to industrial uses. Pangenome analysis publicly available genomes allowed us generate genome-scale metabolic network reconstructions 26 species importance. Their manual curation led more than 75,000 gene-protein-reaction associations were deployed 2,446 models. Cross-referencing and known validation As result, we provide first pangenomic in collection predictive computational models enable variety practical IMPORTANCE , bacterial industry, increasingly relevant biosustainability initiatives. study, leveraging approximately 2,400 genome sequences, provides metabolism, creating over curated validated (GEMs). These GEMs successfully predict (i) unique, species-specific reactions; (ii) niche-enriched reactions increase organism fitness; (iii) essential media components, offering insights into global amino acid essentiality ; (iv) fermentation capabilities family, shedding light on -based commercial products. This quantitative properties will have profound implications food industry biosustainability, new tools strain selection manipulation.

Язык: Английский

---

Effects of Free or Immobilized Pediococcus acidilactici ORE5 on Corinthian Currants on Gut Microbiome of Streptozotocin-Induced Diabetic Rat

Опубликована: Авг. 20, 2024

Type-1 Diabetes Mellitus (T1D) onset and development is closely linked with imbalance of gut microbiome, while supplementation probiotics may result in positive alterations microbiome composition. In the present study, effect a dietary intervention including free or immobilized cells presumptive probiotic Pediococcus acidilactici ORE5 on Corinthian currants, food beneficial impact condition diabetes, was investigated. Male Wistar rats were studied which divided into 4 groups: healthy animals, received (H_FP) (H_IPC), diabetic (D_FP) (D_IPC), for weeks (109 cfu/day, all groups). At end intervention, D_IPC group exerted lower concentration inflammatory cytokine IL-1b compared to D_FP. Consumption currants P. by animals led increased loads fecal lactobacilli levels Enterobacteriaceae, coliforms, E. coli, Actinobacteria phylum, Akkermansia, Bifidobacterium genera abundances increased, lactic acid elevated. Overall, results research demonstrated that functional ingredients can ameliorate dysbiosis T1D could be used design patterns aiming at management. However, well-designed clinical trials are necessary, order confirm effects humans.

Язык: Английский

---