Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(12), С. 390 - 390
Опубликована: Дек. 23, 2024
Scaffolds
resembling
the
extracellular
matrix
(ECM)
provide
structural
support
for
cells
in
engineering
of
tissue
constructs.
Various
material
sources
and
fabrication
techniques
have
been
employed
scaffold
production.
Cellulose-based
matrices
are
interest
due
to
their
abundant
supply,
hydrophilicity,
mechanical
strength,
biological
inertness.
Terrestrial
marine
plants
offer
diverse
morphologies
that
can
replicate
ECM
various
tissues
be
isolated
through
decellularization
protocols.
In
this
study,
three
macroalgae
species—namely
Durvillaea
poha,
Ulva
lactuca,
Ecklonia
radiata—were
selected
morphological
variation.
Low-intensity,
chemical
treatments
were
developed
each
species
maintain
native
cellulose
structures
within
while
facilitating
clearance
DNA
pigment.
generated
from
seaweed
non-toxic
human
dermal
fibroblasts
but
only
fibrous
inner
layer
those
derived
E.
radiata
supported
cell
attachment
maturation
over
seven
days
culture.
These
findings
demonstrate
potential
radiata-derived
scaffolds
skin
highlight
influence
on
efficiency,
properties,
utility.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Abstract
Biopolymer‐based
hydrogels
offer
versatility
in
biomedical
engineering
due
to
their
abundance,
biocompatibility,
tailorable
properties,
and
environmental
responsiveness.
Realizing
full
potential
requires
understanding
the
molecular‐level
design
principles
that
govern
macroscopic
behavior.
This
review
analyzes
recent
advances
molecular
of
biopolymer‐based
hydrogels,
emphasizing
innovative
network
strategies
processing
methods
for
precise
control
over
material
properties
functions.
How
influences
hydrogel
behavior
across
multiple
length
scales
are
explored,
focusing
on:
1)
strategies:
approaches
like
double
networks,
interpenetrating
supramolecular
assemblies
tailor
mechanical
responsive
properties;
2)
techniques:
such
as
Hofmeister
effect‐induced
chain
aggregating,
cononsolvency‐based
porous
structure
controlling,
directional
freezing‐induced
alignment
achieve
hierarchical
anisotropic
structures.
these
influence
critical
strength,
inner
mass
transportation,
degradation
discussed.
The
also
covers
advanced
fabrication
techniques
leverage
create
complex,
functional
hydrogels.
By
elucidating
relationships
between
architecture,
methods,
resulting
this
work
aims
provide
a
framework
designing
next‐generation
with
enhanced
performance
functionality
various
applications.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
Abstract
Diabetic
foot
ulcers
(DFU)
are
notoriously
challenging
to
heal
due
severe
infection,
excessive
inflammation,
and
difficulty
in
angiogenesis.
In
response
these
problems,
first,
a
pH/glucose
dual‐responsive
hydrogel
dressing
(HPC)
is
constructed
using
dual
dynamic
crosslinking
through
Schiff
base
phenylboronate
ester
between
m‐aminophenylboronic
acid
adipic
dihydrazide
bifunctionalized
hyaluronic
(AHP)
oxidized
chondroitin
sulfate
(OCS).
Then,
polydopamine‐reduced
graphene
oxide
compounded
glycine‐modified
fullerene
(GPC)
with
photothermal/photodynamic
synergistic
antibacterial
properties
the
drug
pirfenidone
(PFD)
pro‐angiogenesis
suppress
inflammatory
loaded
into
above
HPC
hydrogel.
Based
on
of
base/phenylboronate
pH/glucose,
HPC/GPC/PFD
(HPCG/PFD)
can
accelerate
release
PFD,
thereby
improving
inflammation
angiogenesis
DFU.
addition,
provided
good
on‐demand
removal
self‐healing
performance,
while
GPC
brought
tissue
adhesion,
antioxidation,
electrical
conductivity
The
rheology,
morphology,
mechanical
properties,
swelling,
degradation,
biocompatibility
have
been
well
verified.
Finally,
DFU
model
rats,
this
promote
wound
repair
by
reducing
infection
accelerating
closure,
enhancing
epidermal
regeneration,
collagen
deposition,
angiogenesis,
showing
promoting
effect
diabetic
healing.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Itaconate
(IA)
is
an
endogenous
metabolite
and
a
potent
regulator
of
the
innate
immune
system.
Its
use
in
immunomodulatory
therapies
has
faced
limitations
due
to
inherent
challenges
achieving
controlled
delivery
requirements
for
high
extracellular
concentrations
achieve
internalization
highly
polar
small
molecule
its
intracellular
therapeutic
activity.
Microparticle
(MP)-based
strategies
are
promising
approach
metabolites
through
macrophage
phagocytosis
subsequent
polymer
degradation-based
delivery.
Toward
goal
IA,
degradable
polyester
polymer-(poly(itaconate-co-dodecanediol))
based
IA
microparticles
(IA-MPs)
were
generated
using
emulsion
method,
forming
micron-scale
(∼
1.5
µm)
microspheres.
IA-MPs
characterized
with
respect
their
material
properties
release
kinetics
inform
particle
fabrication.
Treatment
murine
bone
marrow-derived
macrophages
optimized
concentration
0.1
mg/million
cells
enabled
phagocytosis-mediated
low
levels
cytotoxicity.
Flow
cytometry
demonstrated
IA-MP-specific
regulation
IA-sensitive
inflammatory
targets.
Metabolic
analyses
that
IA-MP
inhibited
oxidative
metabolism
induced
glycolytic
reliance,
consistent
established
mechanism
IA-associated
inhibition
succinate
dehydrogenase.
This
development
IA-based
provides
basis
additional
innovative
metabolite-based
microparticle
drug
systems
treatment
disease.
Environmental Science Processes & Impacts,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Computational
methods
are
crucial
for
assessing
chemical
biodegradability,
given
their
significant
impact
on
both
environmental
and
human
health.
Organic
compounds
that
not
biodegradable
can
persist
in
the
environment,
contributing
to
pollution.
Our
novel
approach
leverages
graph
attention
networks
(GATs)
incorporates
node
edge
attributes
biodegradability
prediction.
Quantitative
Structure-Activity
Relationship
(QSAR)
models
using
two-dimensional
descriptors
alongside
weighted
average
stacking
approaches
were
employed
generate
ensemble
models.
The
GAT
demonstrated
a
stable
function
generally
higher
specificity
validation
set
compared
convolutional
network,
although
definitive
superiority
is
challenging
establish
owing
overlapping
standard
deviations.
However,
sensitivities
tended
decrease
with
potential
performance
overlap
interval
intersection.
Ensemble
learning
enhanced
several
metrics
individual
base
models,
combination
of
extreme
Gradient
Boosting
achieving
highest
precision
specificity.
Combining
random
forest
may
be
preferable
accurately
predicting
molecules,
whereas
suitable
prioritizing
correct
classification
nonbiodegradable
substances.
Important
descriptors,
such
as
SpMax1_Bh(m)
SAscore,
identified
at
least
two
QSAR
Despite
inherent
complexities,
ease
implementation
depends
factors
data
availability,
domain
knowledge.
Assessing
organic
essential
reducing
impact,
risks,
ensuring
regulatory
compliance,
promoting
sustainable
development,
supporting
effective
pollution
remediation.
It
assists
making
informed
decisions
about
use,
waste
management,
protection.
Gels,
Год журнала:
2025,
Номер
11(4), С. 220 - 220
Опубликована: Март 21, 2025
The
rapid
advancement
of
wearable
electronics
has
catalyzed
the
development
flexible,
lightweight,
and
highly
conductive
materials.
Among
these,
hydrogels
have
emerged
as
promising
candidates
due
to
their
tissue-like
properties,
which
can
minimize
mechanical
mismatch
between
flexible
devices
biological
tissues
excellent
electrical
conductivity,
stretchability
biocompatibility.
However,
environmental
impact
synthetic
components
production
processes
in
conventional
poses
significant
challenges
sustainable
application.
This
review
explores
recent
advances
eco-friendly
used
healthcare,
focusing
on
design,
fabrication,
applications
green
electronics.
Emphasis
is
placed
use
natural
polymers,
bio-based
crosslinkers,
synthesis
methods
improve
sustainability
while
maintaining
high
performance.
We
discuss
incorporation
polymers
carbon-based
nanomaterials
into
environmentally
benign
matrices.
Additionally,
article
highlights
strategies
for
improving
biodegradability,
recyclability,
energy
efficiency
these
By
addressing
current
limitations
future
opportunities,
this
aims
provide
a
comprehensive
understanding
friendly
basis
next
generation
technologies.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Freeze–drying
bigels
is
a
novel
technique
for
developing
functional
materials
dermatological
and
cosmetic
use,
leveraging
the
benefits
of
two
structured
phases.
This
study
optimized
freeze–dried
composed
whey
protein
isolate
(WPI)/sodium
alginate/glycerin
hydrogel
ethylcellulose
(EC)/Span
80/sunflower
oil
oleogel
at
varying
hydrogel/oleogel
ratios.
The
showed
swelling
ratios
from
50%
to
255%,
with
higher
values
lower
content
polymer
concentration.
extended
degradation
few
hours
7
days.
concentrations
influenced
Young's
modulus
(1.25–3.7
MPa).
Porosity
varied
35%
58%,
density
100
200
mg/mL.
residual
moisture
(5%
20%)
increased
EC
decreased
WPI
content.
These
findings
underscore
role
phase
in
tuning
physicochemical
properties
gels,
positioning
them
as
promising
biomaterials
skincare
applications.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Itaconate
(IA)
is
an
endogenous
metabolite
and
a
potent
regulator
of
the
innate
immune
system.
It's
use
in
immunomodulatory
therapies
has
faced
limitations
due
to
challenges
controlled
delivery
requirements
high
extracellular
concentrations
for
internalization
highly
polar
small
molecule
achieve
its
intracellular
therapeutic
activity.
Microparticle
(MP)-based
strategies
are
promising
approach
metabolites
through
macrophage
phagocytosis
subsequent
polymer
degradation-based
delivery.
Toward
goal
IA,
degradable
polyester
polymer-
(poly(dodecyl
itaconate))
based
IA
microparticles
(IA-MPs)
generated
using
emulsion
method,
forming
micron-scale
(≈1.5
µm)
microspheres.
IA-MPs
characterized
with
respect
their
material
properties
release
kinetics
inform
particle
fabrication.
Treatment
murine
bone
marrow-derived
macrophages
optimized
concentration
0.1
mg
million-1
cells
enables
phagocytosis-mediated
low
levels
cytotoxicity.
Flow
cytometry
demonstrates
IA-MP-specific
regulation
IA-sensitive
inflammatory
targets.
Metabolic
analyses
demonstrate
that
IA-MP
inhibits
oxidative
metabolism
induced
glycolytic
reliance,
consistent
established
mechanism
IA-associated
inhibition
succinate
dehydrogenase.
This
development
IA-based
provides
basis
additional
innovative
metabolite-based
microparticle
drug
systems
treatment
disease.
