Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Язык: Английский

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pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123322 - 123322

Опубликована: Янв. 1, 2025

Язык: Английский

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Multifunctional, NIR light-responsive, 4D printable polyurethane/polydopamine nanocomposite

Polymer, Год журнала: 2025, Номер unknown, С. 128214 - 128214

Опубликована: Фев. 1, 2025

Язык: Английский

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Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Hydrogels are highly versatile materials with immense potential for tissue engineering and regenerative medicine owing to their biocompatibility, tunable mechanical properties, ability mimic the natural extracellular matrix. Their 3D porous structure allows encapsulation delivery of bioactive molecules, making them ideal candidates drug systems. In repair, particularly bone regeneration, hydrogels can serve as carriers that release therapeutic agents in a controlled manner, thus enhancing healing process. Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles recombinant human Bone Morphogenetic Protein (rhBMP-2) molecules were incorporated solely (ZIF@GelMA) or association (BMP@ZIF@GelMA) into gelatin modified by methacryloyl hydrogel (GelMA) investigate its physical osteogenic properties. characterized Scanning Electron Microscopy rheological tests. We analyzed degradation BSA profile BMP@ZIF@GelMA samples throughout 0, 1, 3, 7, 14, 28 days. Cell adhesion formation markers hydrogel-encapsulated dental pulp cells using immunocytochemistry molecular analysis. ZIF@GelMA exhibited viscoelastic increased storage modulus when rhBMP2 was present. BSA@ZIF@GelMA showed balanced rate BSA. The upregulated expression cell genes, BMP-2 introduced, levels remarkably elevated. presents several favorable factors promote cellular encouraging further prospects advanced applications repair.

Язык: Английский

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Adhesive and Antioxidant Hydrogel with Glucose/ROS Dual-Responsive Drug Release for Diabetic Oral Mucosal Wound Healing

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Diabetes mellitus is a global health threat, with chronic wounds, including oral mucosal being severe complication. These wounds are characterized by delayed healing and increased inflammation due to hyperglycemia, affecting patients' quality of life. Current treatments for cannot offer sustained management these injuries in diabetic patients. Here, glucose/ROS dual-responsive hydrogel incorporating sitagliptin was developed the treatment wounds. After chemical modification tetra-armed poly(ethylene glycol) succinimidyl glutarate (tetra-PEG-SG) dopamine (DA) amine (tetra-PEG-NH2) phenylboronic acid (PBA), resulting capable rapid gelation, robust tissue adhesion, self-healing, antioxidant capacity, dual response glucose reactive oxygen species (ROS), enabling feasible injection stable adherence moist environment while ensuring therapeutic release. In vivo experiments on defects mice revealed that sitagliptin-loaded could effectively reduce promote wound healing. Collectively, this finding identifies potential dressing as strategy

Язык: Английский

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Advancements and Prospects of pH-Responsive Hydrogels in Biomedicine

Gels, Год журнала: 2025, Номер 11(4), С. 293 - 293

Опубликована: Апрель 15, 2025

As an intelligent polymer material, pH-sensitive hydrogels exhibit the capability to dynamically sense alterations in ambient pH levels and subsequently initiate corresponding physical or chemical responses, including swelling, contraction, degradation, ion exchange. Given significant variations inherent human pathophysiological microenvironments, particularly tumor tissues, inflammatory lesions, gastrointestinal system, these smart materials demonstrate remarkable application potential across diverse domains such as targeted drug delivery systems, regenerative medicine engineering, biosensing, disease diagnostics. Recent breakthroughs nanotechnology precision have substantially propelled advancements design of pH-responsive hydrogels. This review systematically elaborates on current research progress future challenges regarding biomedical applications, with particular emphasis their stimulus–response mechanisms, fabrication methodologies, multifunctional integration strategies, scenarios.

Язык: Английский

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Tailoring of a specific pH-induced self-enhanced photothermal cellulose hydrogel for antibiotic-resistant bacteria-infected wound treatment

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163025 - 163025

Опубликована: Апрель 1, 2025

Язык: Английский

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