Double-Negative CD4 CD8 Absolute Count Plays a Mediating Role in the Causal Relationship Between Plasma Lipids and Parkinson’s Disease: A Mendel Randomized Study

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Withaferin A maintained microbiome and metabolome features in A53T transgenic mice via multi-omics integrated analysis

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156725 - 156725

Опубликована: Апрель 1, 2025

Язык: Английский

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Bromelain prevents Alzheimer's disease progression by suppressing oxidative stress and upregulating apolipoprotein A1 in 5x familial Alzheimer's disease transgenic mice

Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101927 - 101927

Опубликована: Апрель 1, 2025

Язык: Английский

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Mass Spectrometry Imaging Reveals Region-Specific Lipid Alterations in the Mouse Brain in Response to Efavirenz Treatment

ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(8), С. 2379 - 2390

Опубликована: Июль 9, 2024

Efavirenz (EFV) is a commonly used drug to treat human immunodeficiency virus infection and known exert adverse effects on the brain. Although it that EFV associated with abnormal plasma lipid levels, changes in spatial localization of individual molecules brain tissue following treatment are yet be explored. In this study, we employed matrix-assisted laser desorption/ionization mass spectrometry imaging approach determine region-specific alterations mouse brains treatment. We detected unique patterns phosphatidylcholine (PC), sphingomyelin (SM), ceramide phosphoinositol (PI-Cer), hexosylceramide (HexCer) Interestingly, PC(32:0), PC(38:5), SM(36:1;O2) showed high abundance hippocampus region, whereas PI-Cer(38:8) exhibited low region EFV-treated brains. Additionally, observed PC(38:6), PC(40:6), PI-Cer(40:3) thalamus Furthermore, SM(40:1;O2), SM(42:2;O2), SM(42:1;O2), SM(43:2;O2), SM(43:1;O2) their accumulation corpus callosum as compared controls. However, HexCer(42:1;O3) depletion response To characterize expression proteins, including metabolizing enzymes, treatment, spectrometry-based proteomics was utilized. From these, levels 12 proteins were found significantly decreased Taken together, these multiomics data provide important insights into metabolism.

Язык: Английский

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Environmental Temperature Variation Affects Brain Lipid Composition in Adult Zebrafish (Danio rerio)

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9629 - 9629

Опубликована: Сен. 5, 2024

This study delves deeper into the impact of environmental temperature variations on nervous system in teleost fish. Previous research has demonstrated that exposing adult zebrafish (Danio rerio) to 18 °C and 34 for 4 or 21 days induces behavioural changes compared fish kept at a control 26 °C, suggesting alterations system. Subsequent studies revealed these conditions also modify brain protein expression, indicating potential neurotoxic effects. The primary aim this work was investigate effects prolonged exposure (21 days) lipidomes temperature. Analysis lipidome highlighted significant alteration relative abundances specific lipid molecules confirming distinct induced by both tested temperatures. Exposure resulted an increase levels phospholipids, such as phosphatidylethanolamine, alongside general reduction sphingolipids, including sphingomyelin. Conversely, produced more pronounced effects, with increases phosphatidylethanolamine those various sphingolipids ceramide, gangliosides, sphingomyelin, ether lysophosphatidylethanolamine ether, phosphatidylglycerol well glycolipids like monogalactosyldiacylglycerol. These results, when integrated existing proteomic data, offer new insights thermal Specifically, our lipidomic findings suggest elevated temperatures may disrupt mitochondrial function, neuronal susceptibility oxidative stress cytotoxicity, alter axonal myelination, impair nerve impulse transmission, hinder synapse function neurotransmitter release, potentially lead increased death. are particularly relevant fields cell biology, neurobiology, ecotoxicology, especially context global warming.

Язык: Английский

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GNLY as a novel cis-eQTL and cis-pQTL mediated susceptibility gene in suppressing prostatitis. Mendelian randomization study

Archives of Medical Research, Год журнала: 2024, Номер 56(2), С. 103098 - 103098

Опубликована: Окт. 21, 2024

Язык: Английский

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Ultra-High-Performance Liquid Chromatography–Orbitrap-MS-Based Untargeted Lipidomics Reveal Lipid Characteristics of a Clinical Strain of Mycoplasma bovis from Holstein Cow

Veterinary Sciences, Год журнала: 2024, Номер 11(11), С. 577 - 577

Опубликована: Ноя. 18, 2024

is a global concern for the cattle industry owing to its high rates of infection and resulting morbidity, but there are no reports on lipid composition metabolic pathways. This study examined lipidomics

Язык: Английский

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