XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1
Cell Host & Microbe,
Год журнала:
2024,
Номер
32(3), С. 315 - 321.e3
Опубликована: Фев. 19, 2024
COVID-19
vaccines
have
recently
been
updated
to
specifically
encode
or
contain
the
spike
protein
of
SARS-CoV-2
XBB.1.5
subvariant,
but
their
immunogenicity
in
humans
has
yet
be
fully
evaluated
and
reported,
particularly
against
emergent
viruses
that
are
rapidly
expanding.
We
now
report
administration
an
monovalent
mRNA
vaccine
booster
(XBB.1.5
MV)
previously
uninfected
individuals
boosted
serum
virus-neutralizing
antibodies
significantly
not
only
(27.0-fold
increase)
EG.5.1
(27.6-fold
also
key
emerging
such
as
HV.1,
HK.3,
JD.1.1,
JN.1
(13.3-
27.4-fold
increase).
Individuals
infected
by
Omicron
subvariant
had
highest
overall
neutralizing
titers
(ID
Язык: Английский
Effectiveness of Omicron XBB.1.5 vaccine against infection with SARS-CoV-2 Omicron XBB and JN.1 variants, prospective cohort study, the Netherlands, October 2023 to January 2024
Eurosurveillance,
Год журнала:
2024,
Номер
29(10)
Опубликована: Март 7, 2024
We
estimated
vaccine
effectiveness
(VE)
of
SARS-CoV-2
Omicron
XBB.1.5
vaccination
against
self-reported
infection
between
9
October
2023
and
January
2024
in
23,895
vaccine-eligible
adults
who
had
previously
received
at
least
one
booster.
VE
was
41%
(95%
CI:
23–55)
18–59-year-olds
50%
44–56)
60–85-year-olds.
Sequencing
data
suggest
lower
protection
the
BA.2.86
(including
JN.1)
variant
from
recent
prior
(OR
=
2.8;
95%
CI:1.2–6.5)
and,
not
statistically
significant,
1.5;
CI:0.8–2.6).
Язык: Английский
SARS-CoV-2 Variants: Genetic Insights, Epidemiological Tracking, and Implications for Vaccine Strategies
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1263 - 1263
Опубликована: Янв. 31, 2025
The
emergence
of
SARS-CoV-2
variants
has
significantly
impacted
the
global
response
to
COVID-19
pandemic.
This
review
examines
genetic
diversity
variants,
their
roles
in
epidemiological
tracking,
and
influence
on
viral
fitness.
Variants
concern
(VOCs)
such
as
Alpha,
Beta,
Gamma,
Delta,
Omicron
have
demonstrated
increased
transmissibility,
altered
pathogenicity,
potential
resistance
neutralizing
antibodies.
Epidemiological
tracking
these
is
crucial
for
understanding
spread,
informing
public
health
interventions,
guiding
vaccine
development.
also
explores
how
specific
mutations
spike
protein
other
genomic
regions
contribute
fitness,
affecting
replication
efficiency,
immune
escape,
transmission
dynamics.
By
integrating
surveillance
data
with
clinical
findings,
this
provides
a
comprehensive
overview
ongoing
evolution
its
implications
strategies
new
Язык: Английский
Immunogen characterization reveals an intrinsic hindrance in eliciting neutralizing antibodies against JN.1 variant
iScience,
Год журнала:
2024,
Номер
27(8), С. 110405 - 110405
Опубликована: Июнь 28, 2024
Язык: Английский
Worldwide SARS-CoV-2 Omicron variant infection: Emerging sub-variants and future vaccination perspectives
Journal of the Formosan Medical Association,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
sparked
widespread
concern
globally,
particularly
with
the
Omicron
variant
and
its
sub-lineages
emerging
as
predominant
cause
of
infection
for
nearly
two
years.
Taiwan's
successful
containment
COVID-19,
underscored
by
broad
vaccine
coverage,
utilization
anti-viral
therapeutics,
timely
response
strategies,
resulted
in
reduced
excess
mortality.
Moreover,
there
is
a
crucial
need
phased
exit
strategy,
balancing
efforts
to
curtail
transmission
mitigation
socioeconomic
impacts
from
rigorous
measures.
In
this
review,
we
examined
evolution
epidemiological
landscape
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
sub-variants
Taiwan
well
other
countries
world.
We
also
critically
evaluated
effectiveness
COVID-19
vaccines
against
various
SARS-CoV-2
variants.
Additionally,
addressed
advantages
heterologous
immunization
fluctuations
neutralizing
antibody
titers,
complexities
establishing
protective
correlates
among
swiftly
mutating
viral
Язык: Английский