Cancers,
Год журнала:
2021,
Номер
13(2), С. 318 - 318
Опубликована: Янв. 16, 2021
Chemotherapy
represents
one
of
the
most
efficacious
strategies
to
treat
cancer
patients,
bringing
advantageous
changes
at
least
temporarily
even
those
patients
with
incurable
malignancies.
However,
respond
poorly
after
a
certain
number
cycles
treatment
due
development
drug
resistance.
Resistance
drugs
administrated
greatly
limits
benefits
that
can
achieve
and
continues
be
severe
clinical
difficulty.
Among
mechanisms
which
have
been
uncovered
mediate
anti-cancer
resistance,
Hippo
signaling
pathway
is
gaining
increasing
attention
remarkable
oncogenic
activities
its
components
(for
example,
YAP
TAZ)
their
druggable
properties.
This
review
will
highlight
current
understanding
how
regulates
resistance
in
tumor
cells,
currently
available
pharmacological
interventions
targeting
eradicate
malignant
cells
potentially
patients.
The
malignant
tumor
is
a
multi-etiological,
systemic
and
complex
disease
characterized
by
uncontrolled
cell
proliferation
distant
metastasis.
Anticancer
treatments
including
adjuvant
therapies
targeted
are
effective
in
eliminating
cancer
cells
but
limited
number
of
patients.
Increasing
evidence
suggests
that
the
extracellular
matrix
(ECM)
plays
an
important
role
development
through
changes
macromolecule
components,
degradation
enzymes
stiffness.
These
variations
under
control
cellular
components
tissue
via
aberrant
activation
signaling
pathways,
interaction
ECM
to
multiple
surface
receptors,
mechanical
impact.
Additionally,
shaped
regulates
immune
which
results
suppressive
microenvironment
hinders
efficacy
immunotherapies.
Thus,
acts
as
barrier
protect
from
supports
progression.
Nevertheless,
profound
regulatory
network
remodeling
hampers
design
individualized
antitumor
treatment.
Here,
we
elaborate
on
composition
ECM,
discuss
specific
mechanisms
remodeling.
Precisely,
highlight
impact
development,
proliferation,
anoikis,
metastasis,
angiogenesis,
lymphangiogenesis,
escape.
Finally,
emphasize
"normalization"
potential
strategy
for
anti-malignant
Frontiers in Cell and Developmental Biology,
Год журнала:
2021,
Номер
9
Опубликована: Май 24, 2021
Biophysical
cues,
such
as
mechanical
properties,
play
a
critical
role
in
tissue
growth
and
homeostasis.
During
organ
development
injury
repair,
compressive
tensional
forces
generated
by
cell-extracellular
matrix
or
cell-cell
interaction
are
key
factors
for
cell
fate
determination.
In
the
vascular
system,
hemodynamic
forces,
shear
stress,
cyclic
stretch
modulate
phenotypes
susceptibility
to
atherosclerosis.
Despite
that
emerging
efforts
have
been
made
investigate
how
mechanotransduction
is
involved
tuning
functions
various
contexts,
regulatory
mechanisms
remain
largely
unknown.
One
of
challenges
understand
signaling
cascades
transmit
cues
from
plasma
membrane
cytoplasm
then
nuclei
generate
mechanoresponsive
transcriptomes.
YAP
its
homolog
TAZ,
Hippo
pathway
effectors,
identified
mechanotransducers
sense
stimuli
relay
signals
control
transcriptional
programs
proliferation,
differentiation,
transformation.
However,
upstream
mechanosensors
YAP/TAZ
downstream
transcriptome
responses
following
activation
repression
not
well
characterized.
Moreover,
mechanoregulation
literature
highly
context-dependent.
this
review,
we
summarize
biomechanical
microenvironment
provide
an
update
on
roles
physiological
pathological
conditions.
Journal of Clinical Medicine,
Год журнала:
2021,
Номер
10(8), С. 1685 - 1685
Опубликована: Апрель 14, 2021
Ewing
sarcoma,
a
highly
aggressive
bone
and
soft-tissue
cancer,
is
considered
prime
example
of
the
paradigms
translocation-positive
sarcoma:
genetically
rather
simple
disease
with
specific
neomorphic-potential
therapeutic
target,
whose
oncogenic
role
was
irrefutably
defined
decades
ago.
This
that
by
definition
has
micrometastatic
at
diagnosis
dismal
prognosis
for
patients
macrometastatic
or
recurrent
disease.
International
collaborations
have
current
standard
care
in
prospective
studies,
delivering
multiple
cycles
systemic
therapy
combined
local
treatment;
both
are
associated
significant
morbidity
may
result
strong
psychological
physical
burden
survivors.
Nevertheless,
combination
non-directed
chemotherapeutics
ever-evolving
modalities
nowadays
achieve
realistic
chance
cure
majority
sarcoma.
In
this
review,
we
focus
on
treatment
while
attempting
to
answer
some
most
pressing
questions
clinical
practice.
addition,
review
provides
scientific
answers
phenomena
occasionally
defines
resulting
translational
studies
needed
overcome
hurdle
treatment-associated
morbidities
and,
importantly,
non-survival.
International Journal of Biological Sciences,
Год журнала:
2020,
Номер
16(12), С. 2014 - 2028
Опубликована: Янв. 1, 2020
Metastasis
is
a
complicated,
multistep
process
that
responsible
for
over
90%
of
cancer-related
death.Metastatic
disease
or
the
movement
cancer
cells
from
one
site
to
another
requires
dramatic
remodeling
cytoskeleton.The
regulation
cell
migration
determined
not
only
by
biochemical
factors
in
microenvironment
but
also
biomechanical
contextual
information
provided
extracellular
matrix
(ECM).The
responses
cytoskeleton
chemical
signals
are
well
characterized
and
understood.However,
mechanisms
response
mechanical
form
externally
applied
force
forces
generated
ECM
still
poorly
understood.Furthermore,
understanding
way
cellular
mechanosensors
interact
with
physical
properties
transmit
activate
cytoskeletal
movements
may
help
identify
an
effective
strategy
treatment
cancer.Here,
we
will
discuss
role
tumor
during
metastasis
how
remodel
through
mechanosensing
transduction.
