Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 23, 2025
The
tumor
microenvironment
functions
as
a
dynamic
and
intricate
ecosystem,
comprising
diverse
array
of
cellular
non-cellular
components
that
precisely
orchestrate
pivotal
behaviors,
including
invasion,
metastasis,
drug
resistance.
While
unraveling
the
interplay
between
behaviors
represents
tremendous
challenge,
recent
research
illuminates
crucial
biological
phenomenon
known
mechanotransduction.
Within
microenvironment,
mechanical
cues
like
tensile
stress,
shear
stiffness
play
role
by
activating
mechanosensitive
effectors
such
PIEZO
proteins,
integrins,
Yes-associated
protein.
This
activation
initiates
cascades
intrinsic
signaling
pathways,
effectively
linking
physical
properties
tissues
to
their
physiological
pathophysiological
processes
morphogenesis,
regeneration,
immunity.
mechanistic
insight
offers
novel
perspective
on
how
within
impact
behaviors.
intricacies
are
yet
be
fully
elucidated,
it
exhibits
distinct
attributes
from
non-malignant
tissues,
elevated
solid
stresses,
interstitial
hypertension,
augmented
matrix
stiffness,
enhanced
viscoelasticity.
These
traits
exert
notable
influences
progression
treatment
responses,
enriching
our
comprehension
multifaceted
nature
microenvironment.
Through
this
innovative
review,
we
aim
provide
new
lens
decipher
contexts,
broadening
knowledge
these
factors
promote
or
inhibit
thus
offering
valuable
insights
identify
potential
targets
for
anti-tumor
strategies.
For
decades,
immunologists
have
studied
the
role
of
circulating
immune
cells
in
host
protection,
with
a
more
recent
appreciation
resident
within
tissue
microenvironment
and
intercommunication
between
nonhematopoietic
cells.
However,
extracellular
matrix
(ECM),
which
comprises
at
least
third
structures,
remains
relatively
underexplored
immunology.
Similarly,
biologists
often
overlook
regulation
complex
structural
matrices
by
system.
We
are
only
beginning
to
understand
scale
ECM
structures
determine
cell
localization
function.
Additionally,
we
need
better
how
dictate
complexity.
This
review
aims
highlight
potential
for
biological
discovery
interface
immunology
biology.
Molecular Metabolism,
Год журнала:
2023,
Номер
74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 4, 2024
Abstract
Dysfunctional
extracellular
matrices
(ECM)
contribute
to
aging
and
disease.
Repairing
dysfunctional
ECM
could
potentially
prevent
age-related
pathologies.
Interventions
promoting
longevity
also
impact
gene
expression.
However,
the
role
of
composition
changes
in
healthy
remains
unclear.
Here
we
perform
proteomics
in-vivo
monitoring
systematically
investigate
(matreotype)
during
C.
elegans
revealing
three
distinct
collagen
dynamics.
Longevity
interventions
slow
stiffening
prolong
expression
collagens
that
are
turned
over.
These
prolonged
dynamics
mediated
by
a
mechanical
feedback
loop
hemidesmosome-containing
structures
span
from
exoskeletal
through
hypodermis,
basement
membrane
ECM,
muscles,
coupling
forces
adjust
via
transcriptional
co-activator
YAP-1
across
tissues.
Our
results
provide
evidence
coordinated
remodeling
mechanotransduction
is
required
sufficient
promote
longevity,
offering
potential
avenues
for
targeting
