Antimicrobial peptides: Application informed by evolution

Science, Год журнала: 2020, Номер 368(6490)

Опубликована: Апрель 30, 2020

Antimicrobial peptides (AMPs) are essential components of immune defenses multicellular organisms and currently in development as anti-infective drugs. AMPs have been classically assumed to broad-spectrum activity simple kinetics, but recent evidence suggests an unexpected degree specificity a high capacity for synergies. Deeper evaluation the molecular evolution population genetics AMP genes reveals more adaptive maintenance polymorphism than has previously appreciated, well loss activity. exhibit pharmacodynamic properties that reduce resistance target microbes, may synergize with one another conventional antibiotics. Both these make attractive translational applications. However, if be used clinically, it is crucial understand their natural biology order lessen risk collateral harm avoid crisis now facing

Язык: Английский

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Reassessing the Host Defense Peptide Landscape

Frontiers in Chemistry, Год журнала: 2019, Номер 7

Опубликована: Фев. 4, 2019

Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial (AMPs) these additional roles prompted a shift in terminology to use the broader term host defense (HDPs) capture multi-functional nature of molecules. In this review, we critically examined role AMPs HDPs infectious diseases inflammation. It is generally accepted are multi-faceted mediators wide range biological processes, with individual activities dependent on their polypeptide sequence. context, explore concept chemical space it applies hypothesize various functions class molecule exist independent overlapping activity landscapes. Finally, outline several emerging highlight how an improved understanding processes can potentially be leveraged more fully realize therapeutic promise HDPs.

Язык: Английский

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Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions

Frontiers in Microbiology, Год журнала: 2019, Номер 10

Опубликована: Дек. 12, 2019

The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Recent work shown that these molecules have great potential not only antimicrobials, but also antibiofilm agents, immune modulators, anti-cancer agents and anti-inflammatories. A better understanding of the mechanism action (MOA) AMPs is an important part discovery more potent less toxic AMPs. Many models techniques been utilized describe MOA. This review will examine how biological assays biophysical methods can be in context multiple functions

Язык: Английский

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Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Окт. 4, 2019

Abstract Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. Here we systematically study evolution to 14 chemically diverse AMPs and 12 antibiotics in Escherichia coli . Our work indicates that against certain AMPs, such as tachyplesin II cecropin P1, limited. Resistance level provided by point mutations gene amplification very low antibiotic-resistant bacteria display no cross-resistance these AMPs. Moreover, genomic fragments derived from wide range soil confer detectable when introduced into native host on plasmids. We have found simple physicochemical features dictate propensity evolve could serve source for development new AMP-based therapeutics less prone resistance, feature necessary avoid any possible interference with our innate immune system.

Язык: Английский

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Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

ACS Pharmacology & Translational Science, Год журнала: 2020, Номер 4(1), С. 8 - 54

Опубликована: Дек. 29, 2020

The ongoing worldwide pandemic due to COVID-19 has created awareness toward ensuring best practices avoid the spread of microorganisms. In this regard, research on creating a surface which destroys or inhibits adherence microbial/viral entities gained renewed interest. Although many reports are available antibacterial materials coatings, there is relatively small amount data use antiviral materials. However, with more geared area, new information being added literature every day. combination and chemical represents potentially path-breaking intervention mitigate disease-causing agents. review, we have surveyed various classes such as small-molecule organics, synthetic biodegradable polymers, silver, TiO2, copper-derived chemicals. protection mechanisms against pathogen colonies discussed in detail, highlights key differences that could determine parameters would govern future development advanced surfaces.

Язык: Английский

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Metal organic framework-based antibacterial agents and their underlying mechanisms

Chemical Society Reviews, Год журнала: 2022, Номер 51(16), С. 7138 - 7169

Опубликована: Янв. 1, 2022

MOFs can kill the bacteria efficiently by multiple mechanisms, such as releasing metal ions and/or antibacterial micro-molecules; performing catalytically active site; acting photosensitizers; mimicking enzymes; based on gas therapy and so on.

Язык: Английский

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Antibiotic resistance: turning evolutionary principles into clinical reality

FEMS Microbiology Reviews, Год журнала: 2020, Номер 44(2), С. 171 - 188

Опубликована: Янв. 24, 2020

Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The past few decades have witnessed rapid progress in our understanding multiple factors that affect emergence and spread antibiotic at population level individual patient. However, process translating this into health policy clinical practice has been slow. Here, we attempt to consolidate current knowledge about evolution ecology a roadmap for future research as well environmental control resistance. At level, examine emergence, transmission dissemination resistance, patient adaptation involving bacterial physiology host resilience. Finally, describe new approaches technologies improving diagnosis treatment minimizing

Язык: Английский

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Antimicrobial peptides towards clinical application: Delivery and formulation

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 175, С. 113818 - 113818

Опубликована: Июнь 4, 2021

Язык: Английский

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Antibiofilm activity of host defence peptides: complexity provides opportunities

Nature Reviews Microbiology, Год журнала: 2021, Номер 19(12), С. 786 - 797

Опубликована: Июнь 28, 2021

Язык: Английский

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Recent Innovations in Bacterial Infection Detection and Treatment

ACS Infectious Diseases, Год журнала: 2021, Номер 7(4), С. 695 - 720

Опубликована: Март 18, 2021

Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic resistance. These can result in tremendous morbidity and mortality, emphasizing the need identify treat pathogenic bacteria quickly effectively. Recent developments detection methods have focused on electrochemical, optical, mass-based biosensors. Advances these systems include implementing multifunctional materials, microfluidic sampling, portable data-processing improve sensitivity, specificity, ease of operation. Concurrently, advances antibacterial treatment largely targeted responsive delivery for both antibiotics alternatives. Antibiotic alternatives described here repurposed drugs, antimicrobial peptides polymers, nucleic acids, small molecules, living systems, bacteriophages. Finally, closed-loop therapies combining fields treatment. This review provides comprehensive summary current trends bacterial infections.

Язык: Английский

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