International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6814 - 6814
Опубликована: Апрель 6, 2023
Nowadays,
bacterial
infections
are
attracting
great
attention
for
the
research
and
development
of
new
antimicrobial
agents.
As
one
quinolones,
ciprofloxacin
(CI)
has
a
broad-spectrum,
strong
antibacterial
effect.
However,
clinical
use
is
limited
by
drug
resistance.
Ciprofloxacin
carbon
dots
(CCDs)
with
enhanced
activity
copper-doped
(Cu-CCDs)
were
synthesized
simple
hydrothermal
method.
The
results
structural
analysis
experiments
show
that
CCDs
Cu-CCDs
have
effective
properties
retaining
active
groups
(-COOH,
C-N,
C-F),
doped
copper
better
In
addition,
shown
excellent
against
E.
coli
S.
aureus
good
biocompatibility,
which
indicates
they
prospects
in
applications.
Therefore,
novel
modified
broad-spectrum
activity,
can
be
used
as
nanomaterials
potential
applications
field
drugs,
this
study.
Bacterial
infection
has
become
one
of
the
leading
causes
death
worldwide,
particularly
in
low-income
countries.
Despite
fact
that
antibiotics
have
provided
successful
management
bacterial
infections,
long-term
overconsumption
and
abuse
contributed
to
emergence
multidrug
resistant
bacteria.
To
address
this
challenge,
nanomaterials
with
intrinsic
antibacterial
properties
or
serve
as
drug
carriers
been
substantially
developed
an
alternative
fight
against
infection.
Systematically
deeply
understanding
mechanisms
is
extremely
important
for
designing
new
therapeutics.
Recently,
nanomaterials-mediated
targeted
bacteria
depletion
either
a
passive
active
manner
most
promising
approaches
treatment
by
increasing
local
concentration
around
cells
enhance
inhibitory
activity
reduce
side
effects.
Passive
targeting
approach
widely
explored
searching
nanomaterial-based
alternatives
antibiotics,
while
strategy
relies
on
biomimetic
biomolecular
surface
feature
can
selectively
recognize
In
review
article,
we
summarize
recent
developments
field
therapy
based
nanomaterials,
which
will
promote
more
innovative
thinking
focusing
multidrug-resistant
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(44)
Опубликована: Июль 28, 2021
Abstract
Nanoscale
materials
have
unique
properties
that
make
them
especially
useful
for
biomedical
diagnostic
applications.
Recent
developments
in
nanoengineering
resulted
increasing
use
of
nanostructures
biosensors.
Various
types
0D,
1D,
2D,
and
3D
been
used
to
improve
biosensor
sensitivity,
selectivity,
limit
detection,
time
result,
among
other
metrics.
These
integrated
into
electrochemical,
optical,
biosensors
this
purpose.
Here,
the
most
recent
advances
nanostructured
are
described.
This
includes
a
discussion
nanoparticles,
nanorods,
nanofibers,
nanopillars,
nanowires,
nanosheets,
indented
nanopatterns
(nanoholes
nanoslits),
nanogaps,
nanochannels,
nanopores,
nanofunctionalized
surfaces,
complex
hierarchical
structures
their
advantages
applications
Clinical
these
nanobiosensors
also
highlighted
along
with
future
directions
diagnostics.
Advanced Sensor and Energy Materials,
Год журнала:
2023,
Номер
2(3), С. 100069 - 100069
Опубликована: Июнь 29, 2023
Among
the
semiconductor
photocatalytic
materials,
zinc
oxide
(ZnO)-based
composites
show
promising
research
prospects
in
field
of
environmental
and
biomedical
materials
due
to
their
simple
preparation,
low
cost,
high
performance,
excellent
physical
stability
biocompatibility.
Therefore,
this
review
summarize
preparation
application
ZnO-based
with
catalytic
performance.
Firstly,
modification
strategies
ZnO
by
researchers
recent
years
are
reviewed,
including
non-metal
doping,
metal
noble
deposition,
compounding
semiconductors
other
surface
methods.
Subsequently,
applications
biomedicine
(antibacterial,
anticancer,
biosensing,
etc.),
pollution
fields
last
five
presented.
Finally,
challenges
faced
future
development
various
discussed.
We
hope
that
will
provide
ideas
for
design
efficient
photocatalysts
based
on
further
applications.
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(14), С. 2384 - 2429
Опубликована: Янв. 1, 2022
The
design
of
antimicrobial
peptide-based
materials
for
biomedical
applications
such
as
fighting
infections
in
various
organs,
cancer
therapy,
gene
delivery
and
detection
bacteria.
Nature Reviews Bioengineering,
Год журнала:
2023,
Номер
1(2), С. 139 - 152
Опубликована: Янв. 26, 2023
Effective
drug
delivery
is
important
in
the
treatment
of
various
biomedical
conditions,
ranging
from
autoimmune
disorders
to
cancer
and
bacterial
infections.
Nanostructured
systems
can
help
overcome
challenges
efficient
such
as
poor
distribution,
inefficient
penetration
across
biological
barriers
off-target
effects.
The
bioinspired
nanotopography
carrier
surfaces
provides
a
physical
cue
modulate
their
interaction
with
systems.
In
this
Review,
we
discuss
how
naturally
occurring
nanotopographical
inspire
design
biomaterials
for
delivery.
We
highlight
nanoscale
surface
modifications
carriers
fabrication
strategies,
followed
by
discussion
about
biointerfaces
regulate
functions.
Key
functionalities
include
bio-adhesion,
barrier
remodelling,
uptake
subcellular
trafficking,
cellular
signalling
modulation,
antimicrobial
interfaces.
Finally,
provide
an
outlook
on
future
applications
delivery,
focus
key
exciting
opportunities
bench
bedside.
Three-dimensional
plays
role
components.
This
Review
discusses
nanotopographies
that
improve
muco-adhesion
cyto-adhesion,
modulation
activities
platforms.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 20, 2024
Bacteria
are
the
most
prevalent
form
of
microorganisms
and
classified
into
two
categories
based
on
their
mode
existence:
intracellular
extracellular.
While
bacteria
beneficial
to
human
health,
others
pathogenic
can
cause
mild
severe
infections.
These
use
various
mechanisms
evade
host
immunity
diseases
in
humans.
The
susceptibility
a
bacterial
infection
depends
effectiveness
immune
system,
overall
genetic
factors.
Malnutrition,
chronic
illnesses,
age-related
vulnerabilities
additional
confounders
disease
severity
phenotypes.
impact
pathogens
public
health
includes
transmission
these
from
healthcare
facilities,
which
contributes
increased
morbidity
mortality.
To
identify
significant
threats
it
is
crucial
understand
global
burden
common
pathogenicity.
This
knowledge
required
improve
immunization
rates,
vaccines,
consider
antimicrobial
resistance
when
assessing
situation.
Many
have
developed
resistance,
has
implications
for
infectious
favors
survival
resilient
microorganisms.
review
emphasizes
significance
understanding
that
this
threat
scale.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 15, 2023
Abstract
Nanomaterials,
specifically
metal
nanoclusters
(NCs),
are
gaining
attention
as
a
promising
class
of
antibacterial
agents.
Metal
NCs
exhibit
properties
due
to
their
ultrasmall
size,
extensive
surface
area,
and
well-controlled
ligands.
The
mechanisms
influenced
by
two
primary
factors:
size
charge.
In
this
review,
we
summarize
the
impacts
charge
on
mechanisms,
interactions
with
bacteria,
factors
that
influence
effects
against
both
gram-negative
gram-positive
bacteria.
Additionally,
highlight
occur
when
negatively
or
positively
charged,
provide
examples
applications
A
better
understanding
relationships
between
activity
will
aid
in
design
synthesis
nanomaterials
for
development
effective
agents
bacterial
infections.
Based
remarkable
achievements
NCs,
review
also
presents
conclusions
current
challenges
future
perspectives
fundamental
investigations
practical
applications.
Graphical
ACS Nano,
Год журнала:
2024,
Номер
18(9), С. 7074 - 7083
Опубликована: Фев. 22, 2024
Utilizing
visible
light
for
water
disinfection
is
a
more
convenient,
safe,
and
practical
alternative
to
ultraviolet-light
sterilization.
Herein,
we
developed
silver
(Ag)
single-atom
anchored
g-C3N4
(P-CN)
nanosheets
(Ag1/CN)
then
utilized
spin-coating
method
fabricate
the
Ag1/CN-based-membrane
effective
antibacterial
performance
in
natural
domestic
wastewater.
The
incorporated
Ag
single
atom
formed
Ag1–N6
motif,
which
increased
charge
density
around
N
atoms,
resulting
built-in
electric
field
∼17.2
times
stronger
than
that
of
pure
P-CN
optimizing
dynamics
reactive
oxygen
species
(ROS)
production.
Additionally,
motif
inhibited
release
ions,
ensuring
good
biocompatibility.
Based
on
first-principles
calculation,
adsorption
energy
O2
Ag1/CN
(−0.32
eV)
was
lower
(−0.07
eV),
indicating
loaded
can
barrier
activation,
generating
extra
*OH
radicals
cooperated
with
*O2–
effectively
neutralize
bacteria.
As
result,
powder-catalyst
concentration
30
ppm
demonstrated
99.9%
efficiency
against
drug-resistant
bacteria
(Escherichia
coli,
Staphylococcus
aureus,
kanamycin-resistant
Escherichia
methicillin-resistant
aureus)
under
visible-light
irradiation
4
h.
This
efficacy
24.8
higher
powder
catalyst.
Moreover,
maintain
bactericidal
wastewater
treatment
using
homemade
flow
device,
demonstrating
its
potential
disinfection.
Notably,
visible-light-driven
catalyst
outperformed
majority
reported
g-C3N4-based
catalysts/membranes.
