The Evolution and Ecology of Bacterial Warfare

Current Biology, Год журнала: 2019, Номер 29(11), С. R521 - R537

Опубликована: Июнь 1, 2019

Язык: Английский

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Quantitative phosphoproteomic reveals that the induction of competence modulates protein phosphorylation in Streptococcus pneumonaie

Journal of Proteomics, Год журнала: 2025, Номер 315, С. 105399 - 105399

Опубликована: Фев. 5, 2025

Язык: Английский

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Bacterial Factors Required for Transmission of Streptococcus pneumoniae in Mammalian Hosts

Cell Host & Microbe, Год журнала: 2019, Номер 25(6), С. 884 - 891.e6

Опубликована: Май 21, 2019

Язык: Английский

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Ecological drift during colonization drives within-host and between-host heterogeneity in an animal-associated symbiont

PLoS Biology, Год журнала: 2024, Номер 22(4), С. e3002304 - e3002304

Опубликована: Апрель 25, 2024

Specialized host–microbe symbioses canonically show greater diversity than expected from simple models, both at the population level and within individual hosts. To understand how this heterogeneity arises, we utilize squash bug, Anasa tristis , its bacterial symbionts in genus Caballeronia . We modulate symbiont bottleneck size inoculum composition during colonization to demonstrate significance of ecological drift, noisy fluctuations community due demographic stochasticity. Consistent with predictions neutral theory biodiversity, found that drift alone can account for between hosts, even when 2 strains are nearly genetically identical. When acting on competing strains, maintain genetic among different hosts by stochastically determining dominant strain each host. Finally, mediates isogenic populations a single host, along consistent gradient running anterior-posterior axis symbiotic organ. Our results structure across scales does not necessarily require host-mediated selection, as it emerge result unrelated competitors. findings illuminate processes might affect transmission, coinfection, nature, which drive evolution microbe–microbe interactions host-associated microbiomes.

Язык: Английский

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Refining the Pneumococcal Competence Regulon by RNA Sequencing

Journal of Bacteriology, Год журнала: 2019, Номер 201(13)

Опубликована: Март 19, 2019

Streptococcus pneumoniae is an opportunistic human pathogen responsible for over a million deaths every year. Although both vaccination programs and antibiotic therapies have been effective in prevention treatment of pneumococcal infections, respectively, the sustainability these solutions uncertain. The genome highly flexible, leading to vaccine escape resistance. This flexibility predominantly facilitated by competence, state allowing cell take up integrate exogenous DNA. Thus, it essential obtain detailed overview gene expression during competence. stressed fact that administration several classes antibiotics can lead Previous studies on competence regulon were performed with microarray technology limited incomplete set known genes. Using RNA sequencing combined up-to-date annotation, we provide updated competence-regulated

Язык: Английский

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Pneumococcal carriage, density, and co-colonization dynamics: A longitudinal study in Indonesian infants

International Journal of Infectious Diseases, Год журнала: 2019, Номер 86, С. 73 - 81

Опубликована: Июнь 25, 2019

Язык: Английский

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Immune exclusion by naturally acquired secretory IgA against pneumococcal pilus-1

Journal of Clinical Investigation, Год журнала: 2019, Номер 130(2), С. 927 - 941

Опубликована: Ноя. 5, 2019

Successful infection by mucosal pathogens requires overcoming the mucus barrier. To better understand this key step, we performed a survey of interactions between human respiratory and pathogen Streptococcus pneumoniae. Pneumococcal adherence to adult nasal fluid was seen only isolates expressing pilus-1. Robust binding independent pilus-1 adhesive properties but required Fab-dependent recognition RrgB, pilus shaft protein, naturally acquired secretory IgA (sIgA). Pilus-1 specific sIgA led bacterial agglutination, interaction agglutinated pneumococci entrapment in particles. test effect these vivo, were preincubated with before intranasal challenge mouse model colonization. treatment resulted rapid immune exclusion pilus-expressing pneumococci. Our findings predict that would select for nonpiliated individuals who RrgB-specific from prior episodes colonization piliated strains. Accordingly, genomic data comparing carried mothers their children showed are less likely be colonized study provides example involving antibody host, major factor driving pneumococcal adaptation.

Язык: Английский

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Temperature and immigration effects on quorum sensing in the biofilms of anaerobic membrane bioreactors

Journal of Environmental Management, Год журнала: 2021, Номер 293, С. 112947 - 112947

Опубликована: Июнь 11, 2021

Язык: Английский

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Coordinated Cell Death in Isogenic Bacterial Populations: Sacrificing Some for the Benefit of Many?

Journal of Molecular Biology, Год журнала: 2019, Номер 431(23), С. 4656 - 4669

Опубликована: Апрель 25, 2019

Язык: Английский

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Serotype-Dependent Effects on the Dynamics of Pneumococcal Colonization and Implications for Transmission

mBio, Год журнала: 2022, Номер 13(2)

Опубликована: Март 15, 2022

Capsule is the major virulence factor and surface antigen of opportunistic respiratory pathogen Streptococcus pneumoniae (Spn). Strains Spn express at least 100 structurally immunologically distinct types (serotypes) capsule, but for unknown reasons only a few are common.

Язык: Английский

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