Nano Today, Год журнала: 2024, Номер 58, С. 102438 - 102438
Опубликована: Авг. 13, 2024
Язык: Английский
Nature Biomedical Engineering, Год журнала: 2024, Номер 8(9), С. 1073 - 1091
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
42
Nature Nanotechnology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
34
National Science Review, Год журнала: 2024, Номер 11(5)
Опубликована: Фев. 7, 2024
ABSTRACT Contrast-enhanced magnetic resonance imaging (CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol ferumoxytol-enhanced MRI (FE-MRI) has significantly reshaped CE-MRI practices. Unlike that enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced agent dosage, extended windows, no nephrotoxicity, higher time efficiency capability molecular imaging. As leading superparamagnetic iron oxide agent, heralded next generation agents. This review delineates applications inherent technical superiority FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging gap between demands engineering innovations. Concurrently, we spotlight emerging themes new breakthroughs. Lastly, share our own insights on potential trajectory shedding light future within medical realm.
Язык: Английский
Процитировано
22
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2022, Номер 15(1)
Опубликована: Авг. 5, 2022
Abstract Advances in nanotechnology and medical science have spurred the development of engineered nanomaterials nanoparticles with particular focus on their applications biomedicine. In particular, gold (AuNPs) been great interest, due to exquisite intrinsic properties, such as ease synthesis surface functionalization, tunable size shape, lack acute toxicity favorable optical, electronic, physicochemical features, which possess value for application biodetection diagnostics purposes, including molecular sensing, photoimaging, under form portable simple biosensors (e.g., lateral flow immunoassays that extensively exploited during current COVID‐19 pandemic). We shall discuss main properties AuNPs, conjugation biorecognition moieties, trends sensing detection biomedicine diagnostics. This article is categorized under: Diagnostic Tools > Biosensing Vitro Nanoparticle‐Based Sensing Vivo Nanodiagnostics Imaging
Язык: Английский
Процитировано
55
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1404 - 1404
Опубликована: Янв. 26, 2022
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. However, despite recent developments in management CVDs, early long outcomes vary considerably patients, especially with current challenges facing detection treatment CVDs. This disparity is due to a lack advanced diagnostic tools targeted therapies, requiring innovative alternative methods. Nanotechnology offers opportunity use nanomaterials improving health controlling diseases. Notably, nanotechnologies have recognized potential applicability managing chronic past few years, cancer Of particular interest nanoparticles as drug carriers increase pharmaco-efficacy safety conventional therapies. Different strategies been proposed CVDs; however, controversies regarding selection nanoformulation slowing their clinical translation. Therefore, this review focuses on nanotechnology for delivery application nanomedicine
Язык: Английский
Процитировано
47
Advanced Materials, Год журнала: 2022, Номер 34(21)
Опубликована: Апрель 15, 2022
Several FDA/EMA-approved nanomedicines have demonstrated improved pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic counterparts. The next step increase therapeutic efficacy depends on tumor accumulation, which can be highly heterogeneous. A clinical tool for patient stratification is urgently awaited. Therefore, a docetaxel-entrapping polymeric nanoparticle (89 Zr-CPC634) radiolabeled, positron emission tomography/computed tomography (PET/CT) imaging performed in seven patients with solid tumors two different doses of CPC634: an on-treatment (containing 60 mg m-2 docetaxel) diagnostic (1-2 dose (NCT03712423). Pharmacokinetic half-life 89 Zr-CPC634 mean 97.0 ± 14.4 h on-treatment, 62.4 12.9 the (p = 0.003). At these accumulation observed 46% 41% lesions median positive 96 post-injection 4.94 4.45%IA kg-1 0.91), respectively. In conclusion, PET/CT accurately reflects thus opens possibility cancer nanomedicine nanoparticles.
Язык: Английский
Процитировано
43
Pharmaceutics, Год журнала: 2022, Номер 14(11), С. 2463 - 2463
Опубликована: Ноя. 15, 2022
The dire need for the assessment of human and environmental endangerments nanoparticulate material has motivated formulation novel scientific tools techniques to detect, quantify, characterize these nanomaterials. Several paradigms possess enormous possibilities applications in many realms nanotoxicology. Furthermore, a large number cases, limited capabilities assess toxicological outcomes customized tailored multifunctional nanoparticles used drug delivery have hindered their full exploitation preclinical clinical settings. With ever-compounded availability materials commercialized settings, an ever-arising popular debate been egressing on whether social, human, costs associated with risks nanomaterials outweigh profits. Here we briefly review various health, pharmaceutical, regulatory aspects nanotoxicology engineered vitro vivo. issues encountered during safety toxicity assessments drug-delivery nanocarriers also summarized. recent trends implicated nanotoxicological evaluations matter vivo discussed. Due absence robust rigid guidelines, researchers currently frequently encounter larger challenges toxicology nanocarriers, which discussed here. Nanotoxicology appreciable significant part translational development as well commercialization potential nanocarriers; hence touched upon. Finally, brief overview provided regarding some nanocarrier-based medicines that are undergoing trials, those recently available patients. It is expected this will instigate interest research community working arena pharmaceutical nanoformulation-based delivery.
Язык: Английский
Процитировано
41
Advanced Science, Год журнала: 2023, Номер 10(36)
Опубликована: Окт. 28, 2023
Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.
Язык: Английский
Процитировано
40
Matter, Год журнала: 2023, Номер 6(3), С. 761 - 799
Опубликована: Фев. 3, 2023
Язык: Английский
Процитировано
33
Nature Nanotechnology, Год журнала: 2023, Номер 19(3), С. 376 - 386
Опубликована: Дек. 29, 2023
Язык: Английский
Процитировано
31