Nano Today, Journal Year: 2024, Volume and Issue: 58, P. 102438 - 102438
Published: Aug. 13, 2024
Language: Английский
Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(9), P. 1073 - 1091
Published: June 24, 2024
Language: Английский
Citations
34
Nature Nanotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 3, 2024
Language: Английский
Citations
22
National Science Review, Journal Year: 2024, Volume and Issue: 11(5)
Published: Feb. 7, 2024
ABSTRACT Contrast-enhanced magnetic resonance imaging (CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol ferumoxytol-enhanced MRI (FE-MRI) has significantly reshaped CE-MRI practices. Unlike that enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced agent dosage, extended windows, no nephrotoxicity, higher time efficiency capability molecular imaging. As leading superparamagnetic iron oxide agent, heralded next generation agents. This review delineates applications inherent technical superiority FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging gap between demands engineering innovations. Concurrently, we spotlight emerging themes new breakthroughs. Lastly, share our own insights on potential trajectory shedding light future within medical realm.
Language: Английский
Citations
20
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 23, 2024
Abstract Background Therapeutic strategies based on scavenging reactive oxygen species (ROS) and suppressing inflammatory cascades are effective in improving functional recovery after spinal cord injury (SCI). However, the lack of targeting nanoparticles (NPs) with powerful antioxidant anti-inflammatory properties hampers clinical translation these strategies. Here, CD44-targeting hyaluronic acid-selenium (HA-Se) NPs were designed prepared for ROS responses injured cord, enhancing recovery. Results The HA-Se easily through direct reduction seleninic acid presence HA. obtained exhibited a remarkable capacity to eliminate free radicals CD44 receptor-facilitated internalization by astrocytes. Moreover, effectively mitigated secretion proinflammatory cytokines (such as IL-1β, TNF-α, IL-6) microglia cells (BV2) upon lipopolysaccharide-induced inflammation. In vivo experiments confirmed that could accumulate within lesion site targeting. As result, demonstrated superior protection axons neurons site, leading enhanced rat model SCI. Conclusions These results highlight potential SCI treatment.
Language: Английский
Citations
17
Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Language: Английский
Citations
2
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Aug. 5, 2022
Abstract Advances in nanotechnology and medical science have spurred the development of engineered nanomaterials nanoparticles with particular focus on their applications biomedicine. In particular, gold (AuNPs) been great interest, due to exquisite intrinsic properties, such as ease synthesis surface functionalization, tunable size shape, lack acute toxicity favorable optical, electronic, physicochemical features, which possess value for application biodetection diagnostics purposes, including molecular sensing, photoimaging, under form portable simple biosensors (e.g., lateral flow immunoassays that extensively exploited during current COVID‐19 pandemic). We shall discuss main properties AuNPs, conjugation biorecognition moieties, trends sensing detection biomedicine diagnostics. This article is categorized under: Diagnostic Tools > Biosensing Vitro Nanoparticle‐Based Sensing Vivo Nanodiagnostics Imaging
Language: Английский
Citations
53
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1404 - 1404
Published: Jan. 26, 2022
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. However, despite recent developments in management CVDs, early long outcomes vary considerably patients, especially with current challenges facing detection treatment CVDs. This disparity is due to a lack advanced diagnostic tools targeted therapies, requiring innovative alternative methods. Nanotechnology offers opportunity use nanomaterials improving health controlling diseases. Notably, nanotechnologies have recognized potential applicability managing chronic past few years, cancer Of particular interest nanoparticles as drug carriers increase pharmaco-efficacy safety conventional therapies. Different strategies been proposed CVDs; however, controversies regarding selection nanoformulation slowing their clinical translation. Therefore, this review focuses on nanotechnology for delivery application nanomedicine
Language: Английский
Citations
45
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(21)
Published: April 15, 2022
Several FDA/EMA-approved nanomedicines have demonstrated improved pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic counterparts. The next step increase therapeutic efficacy depends on tumor accumulation, which can be highly heterogeneous. A clinical tool for patient stratification is urgently awaited. Therefore, a docetaxel-entrapping polymeric nanoparticle (89 Zr-CPC634) radiolabeled, positron emission tomography/computed tomography (PET/CT) imaging performed in seven patients with solid tumors two different doses of CPC634: an on-treatment (containing 60 mg m-2 docetaxel) diagnostic (1-2 dose (NCT03712423). Pharmacokinetic half-life 89 Zr-CPC634 mean 97.0 ± 14.4 h on-treatment, 62.4 12.9 the (p = 0.003). At these accumulation observed 46% 41% lesions median positive 96 post-injection 4.94 4.45%IA kg-1 0.91), respectively. In conclusion, PET/CT accurately reflects thus opens possibility cancer nanomedicine nanoparticles.
Language: Английский
Citations
40
Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)
Published: Oct. 28, 2023
Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.
Language: Английский
Citations
39
Matter, Journal Year: 2023, Volume and Issue: 6(3), P. 761 - 799
Published: Feb. 3, 2023
Language: Английский
Citations
29