Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 15, 2024
Abstract
Diffuse
intrinsic
pontine
glioma
(DIPG)
is
a
highly
lethal
tumor
that
occurs
in
the
brain
stem.
At
present,
there
no
effective
drug
for
DIPG.
In
this
work,
Na/K‐ATPase
inhibitor‐ouabain
(OB)
found
to
efficiently
kill
H3K27M‐mutated
DIPG
at
low
doses,
inhibit
cell
proliferation,
reduce
stemness
first
time,
demonstrating
its
potential
as
chemotherapy
order
increase
blood–brain
barrier
(BBB)
permeability
and
accumulation
of
OB,
acidic‐responsive
engineered
exosomes
loaded
with
OB
(OB@EXO‐LCCP)
are
constructed,
which
within
microenvironment
deliver
cells
achieve
targeted
killing
effect.
vitro
experiments,
OB@EXO‐LCCP
able
release
an
acid‐responsive
manner
effectively
cells.
vivo
significantly
inhibits
growth
prolongs
overall
survival
DIPG‐bearing
mice.
Overall,
can
promote
BBB
tumor‐targeting
ability
thereby
enhancing
DIPG‐killing
reducing
toxicity.
This
study
provides
technical
theoretical
information
precision
therapy
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Abstract
Diabetic
wounds
are
a
common
complication
of
diabetes
and
pose
significant
threat
to
human
health.
High
glucose
concentration
in
the
wound
remains
major
obstacle,
necessitating
effective
strategies
achieve
sustained
consumption
for
synergistic
diabetic
therapy.
In
this
study,
an
Au‐based
nanomaterial
is
developed
that
can
adjust
its
morphology
different
therapeutic
processes.
The
prepared
Au
nanowire
(ANW)
be
converted
into
nanospheres
(AS)
under
ultrasonic
conditions
by
adjusting
amount
polyethylene
glycol
(PEG)
on
surface
convenient
delivery.
Intriguingly,
AS
depolymerized
ANW
again
area,
prolonging
retention
time,
ensuring
continuous
glucose.
After
constructing
morphologically
switchable
nanowire,
polyvinyl
alcohol
(PVA)
applied
it
microneedle
co‐delivered
with
hemoglobin
(Hb)‐resveratrol
(RES)
nanoparticles
streptozotocin
(STZ)‐induced
mouse
model,
degraded
gradually,
Hb‐RES
synergistically
ameliorated
hypoxia,
scavenged
ROS,
inhibited
macrophage
differentiation
pro‐inflammatory
M1
phenotypes.
During
process,
continuously
catalyzed
through
inherent
oxidase
activity.
Thus,
study
provides
novel
insights
long‐term
management
during
healing.
Nanozymes
are
a
class
of
nanomaterials
that
exhibit
catalytic
functions
analogous
to
those
natural
enzymes.
They
demonstrate
considerable
promise
in
the
biomedical
field,
particularly
treatment
bone
infections,
due
their
distinctive
physicochemical
properties
and
adjustable
activities.
Bone
infections
(e.g.,
periprosthetic
osteomyelitis)
challenging
treat
clinically.
Traditional
treatments
often
encounter
issues
related
drug
resistance
suboptimal
anti-infection
outcomes.
The
advent
nanozymes
has
brought
with
it
new
avenue
hope
for
infections.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Knee
osteoarthritis
is
a
common
degenerative
joint
disease
involving
multiple
pathological
processes,
including
energy
metabolism,
cartilage
repair,
and
osteogenesis.
To
investigate
the
alterations
in
critical
metabolic
pathways
differential
proteins
patients
through
metabolomic
proteomic
analyses
to
explore
potential
mechanisms
underlying
synovial
osteogenesis
during
progression.
Metabolomics
was
used
analyze
metabolites
fluid
synovium
of
(osteoarthritis
group:
10;
control
10),
whereas
proteomics
examine
protein
expression.
Alkaline
phosphatase
activity
assessed
evaluate
Upregulation
tricarboxylic
acid
cycle:
Significant
upregulation
cycle
indicated
increased
metabolism
repair
activity.
Arginine
collagen
degradation:
Elevated
levels
ornithine,
proline,
hydroxyproline
reflect
active
degradation
contributing
breakdown.
Abnormal
Phenylalanine
Metabolism:
Increased
phenylalanine
tyrosine
metabolite
suggest
their
involvement
destruction
Synovial
osteogenesis:
expression
type
I
elevated
alkaline
confirmed
occurrence
osteogenesis,
potentially
driven
by
differentiation
fibroblasts,
mesenchymal
stem
cells,
hypertrophic
chondrocytes.
Relationships
between
FN1
TGFBI
are
closely
associated
with
while
provides
source
for
osteogenic
transformation.
Alterations
critical.
The
related
have
as
diagnostic
therapeutic
targets
osteoarthritis.
Osteoarthritis
(OA)
is
the
most
prevalent
degenerative
joint
disorder,
characterized
by
progressive
degradation,
pain,
and
diminished
mobility,
all
of
which
collectively
impair
patients'
quality
life
escalate
healthcare
expenditures.
Current
treatment
options
are
often
inadequate
due
to
limited
efficacy,
adverse
side
effects,
temporary
symptom
relief,
underscoring
urgent
need
for
more
effective
therapeutic
strategies.
Recent
advancements
in
nanomaterials
nanomedicines
offer
promising
solutions
improving
drug
bioavailability,
reducing
effects
providing
targeted
benefits.
This
review
critically
examines
pathogenesis
OA,
highlights
limitations
existing
treatments,
explores
latest
innovations
intelligent
design
OA
therapy,
with
an
emphasis
on
their
engineered
properties,
mechanisms,
translational
potential
clinical
application.
By
compiling
recent
findings,
this
work
aims
inspire
further
exploration
innovation
nanomedicine,
ultimately
advancing
development
personalized
therapies.
Cartilage
tissue
engineering
has
made
significant
strides
in
clinical
regenerative
treatment.
The
success
of
cartilage
regeneration
critically
depends
on
a
favorable
microenvironment
by
means
ideal
bioactive
scaffolds.
However,
total
meniscus
replacement
frequently
entails
harsh
accompanying
chronic
inflammation
and
oxidative
stress
conditions
after
massive
injury,
which
extremely
hinders
repair.
Herein,
"core-shell"
codelivery
nanocarrier
is
developed
to
synergistically
regulate
the
cartilaginous
immune
(CIME)
for
replacement.
In
this
study,
mesoporous
silica
nanoparticles
are
used
encapsulate
an
antioxidant
anti-inflammatory
drug,
Emodin,
core
meanwhile
modify
growth
differentiation
factor
(GDF)
reversible
disulfide
bonds
shell,
together
constructing
system
(Em@MSN-GDF).
synergistic
dual-drug
release
effectively
reverses
followed
successful
promotion
fibrocartilage
vivo.
Subsequently,
Em@MSN-GDF-loaded
cartilage-specific
matrix
hydrogels
combined
with
meniscus-shaped
polycaprolactone
framework
construct
mechanically
reinforced
living
substitute.
As
result,
rabbit
experiments
demonstrate
that
regulates
microenvironment,
thereby
achieving
regeneration.
current
therefore,
offers
nanotreatment
strategy
reverse
