Spatiotemporally Controlled Photothermal-Enhanced Cascade Nanoreactor for Efficient Antitumor Therapy through Tumor Microenvironment Modulation DOI
Li Zhao, Jing Gao, Z T Sun

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(24), P. 28788 - 28797

Published: Dec. 11, 2024

The primary challenges for nanozyme-mediated tumor catalytic therapy are the insufficient activity of nanozymes and inadequate endogenous hydrogen peroxide (H2O2) levels in microenvironment (TME). To address these challenges, FeMOF/Pt/GOx (FMPG), a TME-responsive cascade nanoreactor, was designed photothermal-cascade antitumor therapy. FMPG comprises MIL-100(Fe), an iron-based metal–organic framework material, loaded with ultrasmall platinum nanoparticles (Pt NPs) glucose oxidase (GOx). Within TME, degrades presence high phosphate concentrations, releasing GOx, Fe2+, Pt NPs. GOx consumes glucose, reducing ATP cells inducing starvation state cells. Subsequently, H2O2 produced by overexpressed reacts Fe2+ to generate hydroxyl radicals, facilitating NPs exhibit catalase-like catalyze production oxygen from H2O2, further enhancing starvation. Under 808 nm laser irradiation, as-prepared composites localized heat, enabling effective photothermal This nanoreactor demonstrates efficient inhibition situ consumption compounds, promoting development precise synergetic cancer therapies spatiotemporal controllability.

Language: Английский

Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury DOI
Yuxin Cao, Xiaowei Liu,

Chunjing Guo

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 59 - 76

Published: Jan. 8, 2025

Language: Английский

Citations

5
Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy DOI

Xiumei Guo,

Qionghua Zheng,

Wen Gao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123212 - 123212

Published: Feb. 24, 2025

Language: Английский

Citations

2
Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment DOI
Gang Xiao, Jiabin Zhang,

Tong Lin

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Language: Английский

Citations

1
Multi-omics analysis of synovial tissue and fluid reveals differentially expressed proteins and metabolites in osteoarthritis DOI Creative Commons

Minghao Ge,

Weihao Sun,

Tianhao Xu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Knee osteoarthritis is a common degenerative joint disease involving multiple pathological processes, including energy metabolism, cartilage repair, and osteogenesis. To investigate the alterations in critical metabolic pathways differential proteins patients through metabolomic proteomic analyses to explore potential mechanisms underlying synovial osteogenesis during progression. Metabolomics was used analyze metabolites fluid synovium of (osteoarthritis group: 10; control 10), whereas proteomics examine protein expression. Alkaline phosphatase activity assessed evaluate Upregulation tricarboxylic acid cycle: Significant upregulation cycle indicated increased metabolism repair activity. Arginine collagen degradation: Elevated levels ornithine, proline, hydroxyproline reflect active degradation contributing breakdown. Abnormal Phenylalanine Metabolism: Increased phenylalanine tyrosine metabolite suggest their involvement destruction Synovial osteogenesis: expression type I elevated alkaline confirmed occurrence osteogenesis, potentially driven by differentiation fibroblasts, mesenchymal stem cells, hypertrophic chondrocytes. Relationships between FN1 TGFBI are closely associated with while provides source for osteogenic transformation. Alterations critical. The related have as diagnostic therapeutic targets osteoarthritis.

Language: Английский

Citations

1
Nanozyme-Based Strategies against Bone Infection DOI Creative Commons
Zhenyu Li, Guochao Jia, Zheng Su

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Nanozymes are a class of nanomaterials that exhibit catalytic functions analogous to those natural enzymes. They demonstrate considerable promise in the biomedical field, particularly treatment bone infections, due their distinctive physicochemical properties and adjustable activities. Bone infections (e.g., periprosthetic osteomyelitis) challenging treat clinically. Traditional treatments often encounter issues related drug resistance suboptimal anti-infection outcomes. The advent nanozymes has brought with it new avenue hope for infections.

Language: Английский

Citations

0
Advancements in Uricase formulations: overcoming therapeutic challenges in enzyme replacement therapy DOI Creative Commons

Woo Ho Cho,

HyeSoon Kim,

So‐Yeol Yoo

et al.

Journal of Pharmaceutical Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Co‐Delivery of Morphologically Switchable Au Nanowire and Hemoglobin‐Resveratrol Nanoparticles in the Microneedle for Diabetic Wound Healing Therapy DOI Open Access
Peng Ye, Yuan Yang,

Mengzhe Liu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Diabetic wounds are a common complication of diabetes and pose significant threat to human health. High glucose concentration in the wound remains major obstacle, necessitating effective strategies achieve sustained consumption for synergistic diabetic therapy. In this study, an Au‐based nanomaterial is developed that can adjust its morphology different therapeutic processes. The prepared Au nanowire (ANW) be converted into nanospheres (AS) under ultrasonic conditions by adjusting amount polyethylene glycol (PEG) on surface convenient delivery. Intriguingly, AS depolymerized ANW again area, prolonging retention time, ensuring continuous glucose. After constructing morphologically switchable nanowire, polyvinyl alcohol (PVA) applied it microneedle co‐delivered with hemoglobin (Hb)‐resveratrol (RES) nanoparticles streptozotocin (STZ)‐induced mouse model, degraded gradually, Hb‐RES synergistically ameliorated hypoxia, scavenged ROS, inhibited macrophage differentiation pro‐inflammatory M1 phenotypes. During process, continuously catalyzed through inherent oxidase activity. Thus, study provides novel insights long‐term management during healing.

Language: Английский

Citations

0
Catalytic biomaterials, catalytic biology and catalytic medicine DOI
Hui Huang, Yu Chen

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Intelligent Nanomaterials Design for Osteoarthritis Managements DOI Open Access
Zhihao Chen, Xuan Zheng, Zhengzhi Mu

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Language: Английский

Citations

0
Core–Shell Codelivery Nanocarrier Synergistically Regulates Cartilaginous Immune Microenvironment for Total Meniscus Replacement DOI
Yajie Wang, Bin Tang,

Menghan Zhou

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Cartilage tissue engineering has made significant strides in clinical regenerative treatment. The success of cartilage regeneration critically depends on a favorable microenvironment by means ideal bioactive scaffolds. However, total meniscus replacement frequently entails harsh accompanying chronic inflammation and oxidative stress conditions after massive injury, which extremely hinders repair. Herein, "core-shell" codelivery nanocarrier is developed to synergistically regulate the cartilaginous immune (CIME) for replacement. In this study, mesoporous silica nanoparticles are used encapsulate an antioxidant anti-inflammatory drug, Emodin, core meanwhile modify growth differentiation factor (GDF) reversible disulfide bonds shell, together constructing system (Em@MSN-GDF). synergistic dual-drug release effectively reverses followed successful promotion fibrocartilage vivo. Subsequently, Em@MSN-GDF-loaded cartilage-specific matrix hydrogels combined with meniscus-shaped polycaprolactone framework construct mechanically reinforced living substitute. As result, rabbit experiments demonstrate that regulates microenvironment, thereby achieving regeneration. current therefore, offers nanotreatment strategy reverse

Language: Английский

Citations

0