Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
149, С. 112901 - 112901
Опубликована: Апрель 4, 2022
Despite
enormous
development
in
the
field
of
drug
development,
cancer
still
remains
elusive.
Compromised
immunity
stands
as
a
roadblock
to
successful
pharmacological
execution
anti-cancer
drugs
used
clinically
currently.
Recently
some
breakthrough
treatment
strategy
like
nano-formulation,
extracellular
vesicles
treatment,
natural
antioxidant
therapy,
targeted
immunotherapy,
gene
thermal
ablation
and
magnetic
hyperthermia,
pathomics
radiomics
has
been
developed
tested
pre-clinically
well
clinically.
However,
clinical
efficacy
such
therapies
is
yet
establish
are
too
costly
be
utilized
by
patients
from
poor
developing
countries.
At
this
juncture,
researchers
heading
towards
search
medicines
sources
that
higher
safety
margin
multitarget
compared
conventional
treatments.
Mushroom
traditionally
food
since
time
immemorial
due
its
immunomodulatory
effect
which
loaded
with
proteins,
low
fat
content
cholesterol.
Mushrooms
recommended
one
best
vegetarian
diets
for
immunosuppressed
HIV/AIDS
patients.
well-known
their
activity
impacts
hematopoietic
stem
cells,
lymphocytes,
macrophages,
T
dendritic
cells
(DCs),
killer
(NK)
immune
system.
This
comprehensive
review
article
emphasizes
on
molecular
mechanisms
genesis,
therapy
reported
significant
selected
species
mushrooms
bioactive
phytoconstituents
followed
brief
discussion
recent
metallic
nanoparticles
mushrooms.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(13), С. 7077 - 7077
Опубликована: Июнь 30, 2021
Hyaluronan
(HA)
is
a
natural
glycosaminoglycan
present
in
many
tissues
of
all
vertebrates.
HA
has
various
biological
functions,
which
are
dependent
on
its
molar
mass.
High-molar-mass
anti-angiogenic,
immunosuppressive
and
anti-inflammatory
properties,
while
low-molar-mass
opposite
effects.
also
antioxidative
however
the
other
hand
it
can
be
readily
degraded
by
reactive
oxygen
species.
For
years
been
used
treatment
osteoarthritis,
cosmetics
ophthalmology.
In
last
there
growing
interest
to
applied
fields
medicine
such
as
skin
wound
healing,
tissue
engineering,
dentistry
gene
delivery.
this
review
we
summarize
information
modes
administration,
properties
effects
including
recent
progress
investigation
HA.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 103 - 103
Опубликована: Дек. 21, 2022
Hyaluronic
acid
(HA)
is
a
linear
polysaccharide
and
crucial
component
of
the
extracellular
matrix
(ECM),
maintaining
tissue
hydration
tension.
Moreover,
HA
contributes
to
embryonic
development,
healing,
inflammation,
cancerogenesis.
This
review
summarizes
new
research
on
metabolism
interactions
with
its
binding
proteins,
known
as
hyaladherins
(CD44,
RHAMM),
revealing
molecular
basis
for
distinct
biological
function
in
development
cancer.
The
presence
surface
tumor
cells
sign
an
adverse
prognosis.
involvement
malignancy
has
been
extensively
investigated
using
cancer-free
naked
mole
rats
model.
metabolic
components
are
examined
their
potential
impact
promoting
or
inhibiting
formation,
proliferation,
invasion,
metastatic
spread.
High
weight
associated
homeostasis
protective
action
due
ability
preserve
integrity.
In
contrast,
low
indicates
pathological
condition
plays
role
pro-oncogenic
activity.
A
systematic
approach
might
uncover
processes
related
cancer
growth,
establish
novel
prognostic
indicators,
identify
targets
treatment
action.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
149, С. 112901 - 112901
Опубликована: Апрель 4, 2022
Despite
enormous
development
in
the
field
of
drug
development,
cancer
still
remains
elusive.
Compromised
immunity
stands
as
a
roadblock
to
successful
pharmacological
execution
anti-cancer
drugs
used
clinically
currently.
Recently
some
breakthrough
treatment
strategy
like
nano-formulation,
extracellular
vesicles
treatment,
natural
antioxidant
therapy,
targeted
immunotherapy,
gene
thermal
ablation
and
magnetic
hyperthermia,
pathomics
radiomics
has
been
developed
tested
pre-clinically
well
clinically.
However,
clinical
efficacy
such
therapies
is
yet
establish
are
too
costly
be
utilized
by
patients
from
poor
developing
countries.
At
this
juncture,
researchers
heading
towards
search
medicines
sources
that
higher
safety
margin
multitarget
compared
conventional
treatments.
Mushroom
traditionally
food
since
time
immemorial
due
its
immunomodulatory
effect
which
loaded
with
proteins,
low
fat
content
cholesterol.
Mushrooms
recommended
one
best
vegetarian
diets
for
immunosuppressed
HIV/AIDS
patients.
well-known
their
activity
impacts
hematopoietic
stem
cells,
lymphocytes,
macrophages,
T
dendritic
cells
(DCs),
killer
(NK)
immune
system.
This
comprehensive
review
article
emphasizes
on
molecular
mechanisms
genesis,
therapy
reported
significant
selected
species
mushrooms
bioactive
phytoconstituents
followed
brief
discussion
recent
metallic
nanoparticles
mushrooms.
