Biomolecules,
Год журнала:
2021,
Номер
11(11), С. 1551 - 1551
Опубликована: Окт. 20, 2021
Signaling
from
an
actively
remodeling
extracellular
matrix
(ECM)
has
emerged
as
a
critical
factor
in
regulating
both
the
repair
of
tissue
injuries
and
progression
diseases
such
metastatic
cancer.
Hyaluronan
(HA)
is
major
component
ECM
that
normally
functions
injury
to
sequentially
promote
then
suppress
inflammation
fibrosis,
duality
which
featured,
regulated
in,
wound
repair.
These
essential
response-to-injury
HA
microenvironment
are
hijacked
by
tumor
cells
for
invasion
avoidance
immune
detection.
In
this
review,
we
first
discuss
numerous
size-dependent
emphasize
multifunctional
nature
two
its
receptors
(CD44
RHAMM)
signaling
excisional
healing.
This
followed
discussion
how
metabolism
de-regulated
malignant
targeting
might
be
used
better
manage
breast
cancer
progression.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 739 - 739
Опубликована: Фев. 5, 2024
Hyaluronan
(HA)
is
a
non-sulfated
glycosaminoglycan
that
present
in
variety
of
body
tissues
and
organs.
has
wide
range
biological
activities
are
frequently
influenced
by
molar
mass;
however,
they
also
depend
greatly
on
the
source,
purity,
kind
impurities
hyaluronan.
High-molar-mass
HA
anti-inflammatory,
immunosuppressive,
antiangiogenic
properties,
while
low-molar-mass
opposite
properties.
A
number
chemical
modifications
have
been
performed
to
enhance
stability
its
applications
medical
practice.
widely
applied
medicine,
such
as
viscosupplementation,
ophthalmology,
otolaryngology,
wound
healing,
cosmetics,
drug
delivery.
In
this
review,
we
summarized
several
polymers
based
hyaluronan
backbone.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 764 - 764
Опубликована: Янв. 17, 2025
Marine
polysaccharide
hydrogels
have
emerged
as
an
innovative
platform
for
regulating
the
in
vivo
release
of
natural
bioactive
compounds
medical
purposes.
These
hydrogels,
which
exceptional
biocompatibility,
biodegradability,
and
high
water
absorption
capacity,
create
effective
matrices
encapsulating
different
molecules.
In
addition,
by
modifying
physical
chemical
properties
marine
including
cross-linking
density,
swelling
behavior,
response
to
external
stimuli
like
pH,
temperature,
or
ionic
strength,
profile
encapsulated
is
strictly
regulated,
thus
maximizing
therapeutic
efficacy
minimizing
side
effects.
Finally,
using
naturally
sourced
polysaccharides
hydrogel
formulations,
sustainability
promoted
reducing
dependence
on
synthetic
polymers,
meeting
growing
demand
eco-friendly
materials.
This
review
analyzes
interaction
between
offers
examples
how
molecules
can
be
encapsulated,
released,
stabilized.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Фев. 11, 2022
Hyaluronan,
the
extracellular
matrix
glycosaminoglycan,
is
an
important
structural
component
of
many
tissues
playing
a
critical
role
in
variety
biological
contexts.
This
makes
hyaluronan,
which
can
be
biotechnologically
produced
large
scale,
attractive
starting
polymer
for
chemical
modifications.
review
provides
broad
overview
different
synthesis
strategies
used
modulating
as
well
material
properties
this
polysaccharide.
We
discuss
current
advances
and
challenges
derivatization
reactions
targeting
primary
secondary
hydroxyl
groups
or
carboxylic
acid
Journal of Polymer Science,
Год журнала:
2024,
Номер
62(11), С. 2320 - 2339
Опубликована: Март 8, 2024
Abstract
Bacterial
infections
are
common
during
skin
wound
healing,
which
can
interrupt
the
healing
process,
delay
and
seriously
affect
quality
of
life.
Long‐term
antibiotic
treatment
may
lead
to
development
drug
resistance.
Traditional
bandages,
sponges,
films,
textiles
commonly
single‐functional,
usually
fail
satisfy
complicated
needs
process.
In
recent
years,
antibacterial
hydrogel
dressings
have
received
extensive
attention
for
infected
chronic
wounds,
serve
as
biocompatible,
multifunctional
platforms
both
promoting
tissue
regeneration
inhibiting
bacterial
infection.
Cationic
polymers
with
inherent
properties
been
used
backbone,
metal
ions
nanoparticles
be
loaded
in
hydrogels
enhance
effects.
Besides,
various
drugs
bioactive
factors
incorporated
provide
anti‐inflammatory
antioxidant
activities
environment
healing.
Additionally,
adhesion
advantages
fixing
at
sites
dressing‐tissue
interactions.
this
review,
we
focus
on
designing
strategies
tissue‐adhesive,
antibacterial,
naturally‐derived
polymer
treating
wounds.
The
typical
mechanisms
summarized.
Finally,
prospects
challenges
further
multi‐functional
treat
wounds
proposed.
Pharmaceutics,
Год журнала:
2022,
Номер
14(2), С. 297 - 297
Опубликована: Янв. 27, 2022
The
encapsulation
of
cells
with
various
polyelectrolytes
through
layer-by-layer
(LbL)
has
become
a
popular
strategy
in
cellular
function
engineering.
technique
sprang
up
1990s
and
obtained
tremendous
advances
multi-functionalized
recent
years.
This
review
comprehensively
summarized
the
basis
applications
drug
delivery
by
means
LbL
cell
encapsulation.
To
begin
with,
concept
brief
history
were
introduced.
Next,
diverse
types
materials,
including
naturally
extracted
chemically
synthesized,
exhibited,
followed
complicated
assembly,
such
as
interactions
within
multilayers,
charge
distribution,
films
morphology.
Furthermore,
focused
on
protective
effects
against
adverse
factors,
bioactive
payloads
incorporation
could
be
realized
via
Additionally,
payload
from
system
adjusted
environment,
redox,
biological
processes,
functional
linkers
to
release
controlled
manners.
In
short,
encapsulation,
which
takes
advantage
both
grafts
activities,
will
great
importance
basic
research
science
biotherapy
for
diseases.
Pharmaceutics,
Год журнала:
2022,
Номер
14(10), С. 2092 - 2092
Опубликована: Сен. 30, 2022
Cancer
cells
normally
develop
the
ability
to
rewire
or
reprogram
themselves
become
resistant
treatments
that
were
previously
effective.
Despite
progress
in
understanding
drug
resistance,
knowledge
gaps
remain
regarding
underlying
biological
causes
of
resistance
and
design
cancer
overcome
it.
So,
acquisition
remains
a
major
problem
treatment.
Targeted
therapeutics
are
considered
next
generation
therapy
because
they
many
limitations
traditional
treatments.
Numerous
tumor
overexpress
several
receptors
have
high
binding
affinity
for
hyaluronic
acid
(HA),
while
poorly
expressed
normal
body
cells.
HA
its
derivatives
advantage
being
biocompatible
biodegradable
may
be
conjugated
with
variety
drugs
carriers
developing
various
formulations
as
anticancer
therapies
such
micelles,
nanogels,
inorganic
nanoparticles.
Due
their
stability
blood
circulation
predictable
delivery
patterns,
enhanced
tumor-selective
accumulation,
decreased
toxicity
tissues,
tumor-targeting
nanomaterial-based
systems
been
shown
represent
an
efficacious
approach
treatment
cancer.
In
this
review,
we
aim
provide
overview
some
vitro
vivo
studies
related
potential
ligand
targeted
nanovehicles
future
biomedical
applications
Ocular
posterior
segment
diseases
such
as
uveitis,
X-linked
juvenile
retinoschisis,
or
age-related
macular
degeneration
usually
result
in
progressive
and
irreversible
vision
loss.
Although
intravitreal
injection
is
the
main
way
to
deliver
drugs
eye,
it
still
has
shortcomings
an
invasive
operation.
Nanocontrolled
drug
delivery
technology
a
promising
option
avoid
frequent
injections.
Due
particularity
of
human
intraocular
structure,
have
unique
pharmacokinetic
characteristics
eye.
Various
nanoparticles
been
successfully
investigated
experimental
studies
for
vitreous
injection,
with
advantages
drawbacks.
Here,
we
introduce
ideal
nanopolymer
modifier
build
nanodelivery
systems
cavities.
Hyaluronic
acid
(HA)
natural
polysaccharide
broad
molecular
weight
range,
negatively
charged
surface,
ligand–receptor
binding
capabilities,
hyaluronidase
breakdown
capability.
Advances
CD44
receptor
targeting
HA-based
can
improve
mobility
penetration
retina,
stabilize
nanoparticles,
regulate
release.
This
review
summarizes
administration
nanoplatforms
based
on
HA
benefits
systems.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3216 - 3216
Опубликована: Март 12, 2024
Hyaluronic
acid
(HA)
is
a
remarkably
multifaceted
biomacromolecule,
playing
role
in
regulating
myriad
biological
processes
such
as
wound
healing,
tissue
regeneration,
anti-inflammation,
and
immunomodulation.
Crosslinked
high-
low-molecular-weight
hyaluronic
hydrogels
achieve
higher
molar
concentrations,
display
slower
degradation,
allow
optimal
product
diffusion,
while
harnessing
the
synergistic
contribution
of
different-molecular-weight
hyaluronans.
A
recent
innovation
world
synthesis
represented
by
NAHYCO®
Hybrid
Technology,
thermal
process
leading
to
hybrid
cooperative
complexes
(HCC).
This
review
summarizes
current
literature
on
vitro
studies
vivo
applications
HCC,
from
facial
body
rejuvenation
future
perspectives
skin
dermatology,
genitourinary
pathologies.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
Adipose
mesenchymal
stem
cell
(ADMSC)-derived
exosomes
(ADMSC-Exos)
have
shown
great
potential
in
regenerative
medicine
and
been
evidenced
benefiting
wound
repair
such
as
burns.
However,
the
low
yield,
easy
loss
after
direct
coating,
no
suitable
loading
system
to
improve
their
availability
efficacy
hinder
clinical
application
for
healing.
And
few
studies
focused
on
comparison
of
biological
functions
between
derived
from
different
culture
techniques,
especially
exosome-releasing
hydrogel
system.
Therefore,
we
designed
a
high-performance
exosome
controllable
releasing
burn
healing,
namely
3D-printed
microfiber
culture-derived
highly
biocompatible
hyaluronic
acid
(HA).
In
this
project,
compared
vitro
model
among
conventional
two-dimensional
(2D)
plate
(2D-Exos),
microcarrier
(2.5D-Exos),
(3D-Exos).
Results
showed
that
with
2D-Exos
2.5D-Exos,
3D-Exos
promoted
HACATs
HUVECs
proliferation
migration
more
significantly.
Additionally,
had
stronger
angiogenesis-promoting
effects
tube
formation
(HUVECs)
cells.
Moreover,
found
HA-loaded
better
healing
promotion
including
accelerated
rate
collagen
remodeling.
The
study
findings
reveal
HA-loaded,
controllable-release
distinctly
augments
therapeutic
terms
while
concurrently
introducing
facile
approach.
This
markedly
bolsters
exosomal
efficiency,
provides
robust
protective
milieu,
potentiates
inherent
functionalities
exosomes.
Our
provide
rationale
efficient
utilization
high-quality
high-yield
3D
future,
novel
strategy
severe
