The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403

Опубликована: Март 1, 2023

Язык: Английский

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Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, Год журнала: 2021, Номер 20(1)

Опубликована: Окт. 11, 2021

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote growth, angiogenesis, invasion metastasis, along extracellular matrix (ECM) remodeling even chemoresistance. Numerous previous studies have confirmed critical role interaction between cells in tumorigenesis development. However, recently, mutual effects immune (TIME) been identified as another key factor promoting progression. The TIME mainly consists distinct populations islets is highly associated antitumor immunological state TME. interact tumor-infiltrating well other within via secretion various cytokines, growth factors, chemokines, exosomes effector molecules, consequently shaping an immunosuppressive TME that enables cancer to evade surveillance system. In-depth interactions, particularly complicated mechanisms connecting cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding direct indirect crosstalk infiltrating further summarize possible immunoinhibitory induced by In addition, present current related CAF-targeting immunotherapies briefly describe some future perspectives CAF research end.

Язык: Английский

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Therapeutic cancer vaccines

Nature reviews. Cancer, Год журнала: 2021, Номер 21(6), С. 360 - 378

Опубликована: Апрель 27, 2021

Язык: Английский

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Therapeutic Targeting of the Tumor Microenvironment

Cancer Discovery, Год журнала: 2021, Номер 11(4), С. 933 - 959

Опубликована: Апрель 1, 2021

Abstract Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due critical roles of TME regulating progression and modulating response standard-of-care therapies. Here, we summarize current knowledge regarding most advanced TME-directed therapies, which either been clinically approved or are currently being evaluated trials, including immunotherapies, antiangiogenic drugs, treatments directed against cancer-associated fibroblasts extracellular matrix. We also discuss some challenges associated with future perspectives this evolving field. Significance: This review provides comprehensive analysis therapies targeting TME, combining discussion underlying basic biology clinical evaluation different therapeutic approaches, highlighting perspectives.

Язык: Английский

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A single-cell and spatially resolved atlas of human breast cancers

Nature Genetics, Год журнала: 2021, Номер 53(9), С. 1334 - 1347

Опубликована: Сен. 1, 2021

Язык: Английский

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The updated landscape of tumor microenvironment and drug repurposing

Signal Transduction and Targeted Therapy, Год журнала: 2020, Номер 5(1)

Опубликована: Авг. 25, 2020

Abstract Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram initiation, growth, invasion, metastasis, response to therapies. Cancer research treatment have switched from a cancer-centric model TME-centric one, considering the increasing significance of TME cancer biology. Nonetheless, clinical efficacy therapeutic strategies targeting TME, especially specific cells or pathways remains unsatisfactory. Classifying chemopathological characteristics crosstalk among one another greatly benefit further studies exploring effective treating methods. Herein, we present an updated image with emphasis on hypoxic niche, immune microenvironment, metabolism acidic innervated mechanical microenvironment. We then summarize conventional drugs including aspirin, celecoxib, β-adrenergic antagonist, metformin, statin new antitumor application. These are considered as viable candidates for combination therapy due their activity extensive use practice. also provide our outlook directions potential applications theory. This review depicts comprehensive vivid landscape biology treatment.

Язык: Английский

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Diversity and Biology of Cancer-Associated Fibroblasts

Physiological Reviews, Год журнала: 2020, Номер 101(1), С. 147 - 176

Опубликована: Май 29, 2020

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite presence of non-neoplastic stromal components that substantially contribute progression tumor. Indeed, cancer cell survival, growth, migration, and even dormancy are influenced by surrounding tumor microenvironment (TME). Within TME, cancer-associated fibroblasts (CAFs) been shown play several roles in development a They secrete growth factors, inflammatory ligands, extracellular matrix proteins promote proliferation, therapy resistance, immune exclusion. However, recent work indicates CAFs may also restrain some circumstances. In this review, we summarize body CAFs, with particular focus most discoveries about fibroblast heterogeneity, plasticity, functions. We highlight commonalities present across different types, normal states. Finally, latest advances regarding therapeutic strategies undergoing preclinical clinical evaluation.

Язык: Английский

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Clinical and therapeutic relevance of cancer-associated fibroblasts

Nature Reviews Clinical Oncology, Год журнала: 2021, Номер 18(12), С. 792 - 804

Опубликована: Сен. 6, 2021

Язык: Английский

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The matrix in cancer

Nature reviews. Cancer, Год журнала: 2021, Номер 21(4), С. 217 - 238

Опубликована: Фев. 15, 2021

Язык: Английский

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Fibroblasts: Origins, definitions, and functions in health and disease

Cell, Год журнала: 2021, Номер 184(15), С. 3852 - 3872

Опубликована: Июль 1, 2021

Язык: Английский

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