Cell,
Journal Year:
2023,
Volume and Issue:
186(19), P. 4007 - 4037
Published: Sept. 1, 2023
The
TGF-β
regulatory
system
plays
crucial
roles
in
the
preservation
of
organismal
integrity.
signaling
controls
metazoan
embryo
development,
tissue
homeostasis,
and
injury
repair
through
coordinated
effects
on
cell
proliferation,
phenotypic
plasticity,
migration,
metabolic
adaptation,
immune
surveillance
multiple
types
shared
ecosystems.
Defects
signaling,
particularly
epithelial
cells,
fibroblasts,
disrupt
tolerance,
promote
inflammation,
underlie
pathogenesis
fibrosis
cancer,
contribute
to
resistance
these
diseases
treatment.
Here,
we
review
how
coordinates
multicellular
response
programs
health
disease
this
knowledge
can
be
leveraged
develop
treatments
for
system.
Molecular Cancer,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: Oct. 11, 2021
Abstract
Cancer-associated
fibroblasts
(CAFs),
a
stromal
cell
population
with
cell-of-origin,
phenotypic
and
functional
heterogeneity,
are
the
most
essential
components
of
tumor
microenvironment
(TME).
Through
multiple
pathways,
activated
CAFs
can
promote
growth,
angiogenesis,
invasion
metastasis,
along
extracellular
matrix
(ECM)
remodeling
even
chemoresistance.
Numerous
previous
studies
have
confirmed
critical
role
interaction
between
cells
in
tumorigenesis
development.
However,
recently,
mutual
effects
immune
(TIME)
been
identified
as
another
key
factor
promoting
progression.
The
TIME
mainly
consists
distinct
populations
islets
is
highly
associated
antitumor
immunological
state
TME.
interact
tumor-infiltrating
well
other
within
via
secretion
various
cytokines,
growth
factors,
chemokines,
exosomes
effector
molecules,
consequently
shaping
an
immunosuppressive
TME
that
enables
cancer
to
evade
surveillance
system.
In-depth
interactions,
particularly
complicated
mechanisms
connecting
cells,
might
provide
novel
strategies
for
subsequent
targeted
immunotherapies.
Herein,
we
shed
light
on
recent
advances
regarding
direct
indirect
crosstalk
infiltrating
further
summarize
possible
immunoinhibitory
induced
by
In
addition,
present
current
related
CAF-targeting
immunotherapies
briefly
describe
some
future
perspectives
CAF
research
end.
Cancer Discovery,
Journal Year:
2021,
Volume and Issue:
11(4), P. 933 - 959
Published: April 1, 2021
Abstract
Strategies
to
therapeutically
target
the
tumor
microenvironment
(TME)
have
emerged
as
a
promising
approach
for
cancer
treatment
in
recent
years
due
critical
roles
of
TME
regulating
progression
and
modulating
response
standard-of-care
therapies.
Here,
we
summarize
current
knowledge
regarding
most
advanced
TME-directed
therapies,
which
either
been
clinically
approved
or
are
currently
being
evaluated
trials,
including
immunotherapies,
antiangiogenic
drugs,
treatments
directed
against
cancer-associated
fibroblasts
extracellular
matrix.
We
also
discuss
some
challenges
associated
with
future
perspectives
this
evolving
field.
Significance:
This
review
provides
comprehensive
analysis
therapies
targeting
TME,
combining
discussion
underlying
basic
biology
clinical
evaluation
different
therapeutic
approaches,
highlighting
perspectives.
Signal Transduction and Targeted Therapy,
Journal Year:
2020,
Volume and Issue:
5(1)
Published: Aug. 25, 2020
Abstract
Accumulating
evidence
shows
that
cellular
and
acellular
components
in
tumor
microenvironment
(TME)
can
reprogram
initiation,
growth,
invasion,
metastasis,
response
to
therapies.
Cancer
research
treatment
have
switched
from
a
cancer-centric
model
TME-centric
one,
considering
the
increasing
significance
of
TME
cancer
biology.
Nonetheless,
clinical
efficacy
therapeutic
strategies
targeting
TME,
especially
specific
cells
or
pathways
remains
unsatisfactory.
Classifying
chemopathological
characteristics
crosstalk
among
one
another
greatly
benefit
further
studies
exploring
effective
treating
methods.
Herein,
we
present
an
updated
image
with
emphasis
on
hypoxic
niche,
immune
microenvironment,
metabolism
acidic
innervated
mechanical
microenvironment.
We
then
summarize
conventional
drugs
including
aspirin,
celecoxib,
β-adrenergic
antagonist,
metformin,
statin
new
antitumor
application.
These
are
considered
as
viable
candidates
for
combination
therapy
due
their
activity
extensive
use
practice.
also
provide
our
outlook
directions
potential
applications
theory.
This
review
depicts
comprehensive
vivid
landscape
biology
treatment.
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
101(1), P. 147 - 176
Published: May 29, 2020
Efforts
to
develop
anti-cancer
therapies
have
largely
focused
on
targeting
the
epithelial
compartment,
despite
presence
of
non-neoplastic
stromal
components
that
substantially
contribute
progression
tumor.
Indeed,
cancer
cell
survival,
growth,
migration,
and
even
dormancy
are
influenced
by
surrounding
tumor
microenvironment
(TME).
Within
TME,
cancer-associated
fibroblasts
(CAFs)
been
shown
play
several
roles
in
development
a
They
secrete
growth
factors,
inflammatory
ligands,
extracellular
matrix
proteins
promote
proliferation,
therapy
resistance,
immune
exclusion.
However,
recent
work
indicates
CAFs
may
also
restrain
some
circumstances.
In
this
review,
we
summarize
body
CAFs,
with
particular
focus
most
discoveries
about
fibroblast
heterogeneity,
plasticity,
functions.
We
highlight
commonalities
present
across
different
types,
normal
states.
Finally,
latest
advances
regarding
therapeutic
strategies
undergoing
preclinical
clinical
evaluation.
