Endocrine Reviews,
Год журнала:
2021,
Номер
42(6), С. 839 - 871
Опубликована: Март 8, 2021
The
endoplasmic
reticulum
(ER)
hosts
linear
polypeptides
and
fosters
natural
folding
of
proteins
through
ER-residing
chaperones
enzymes.
Failure
the
ER
to
align
compose
proper
protein
architecture
leads
accumulation
misfolded/unfolded
in
lumen,
which
disturbs
homeostasis
provoke
stress.
Presence
stress
initiates
cytoprotective
unfolded
response
(UPR)
restore
or
instigates
a
rather
maladaptive
UPR
promote
cell
death.
Although
wide
array
cellular
processes
such
as
persistent
autophagy,
dysregulated
mitophagy,
secretion
proinflammatory
cytokines
may
contribute
onset
progression
cardiometabolic
diseases,
it
is
well
perceived
that
also
evokes
development
particularly
cardiovascular
diseases
(CVDs),
diabetes
mellitus,
obesity,
chronic
kidney
disease
(CKD).
Meanwhile,
these
pathological
conditions
further
aggravate
stress,
creating
vicious
cycle.
Here
this
review,
we
aimed
at
summarizing
updating
available
information
on
CVDs,
CKD,
hoping
offer
novel
insights
for
management
comorbidities
regulation
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
12
Опубликована: Ноя. 3, 2021
Traditional
Chinese
medicine
plays
a
significant
role
in
the
treatment
of
various
diseases
and
has
attracted
increasing
attention
for
clinical
applications.
Vascular
affecting
vasculature
heart,
cerebrovascular
disease,
atherosclerosis,
diabetic
complications
have
compromised
quality
life
affected
individuals
increase
burden
on
health
care
services.
Berberine,
naturally
occurring
isoquinoline
alkaloid
form
Rhizoma
coptidis
,
is
widely
used
China
as
folk
its
antibacterial
anti-inflammatory
properties.
Promisingly,
an
number
studies
identified
several
cellular
molecular
targets
berberine,
indicating
potential
alternative
therapeutic
strategy
vascular
diseases,
well
providing
novel
evidence
that
supports
berberine
to
combat
diseases.
The
purpose
this
review
comprehensively
systematically
describe
agent
including
pharmacological
effects,
mechanisms,
pharmacokinetics.
According
data
published
so
far,
shows
remarkable
anti-inflammatory,
antioxidant,
antiapoptotic,
antiautophagic
activity
via
regulation
multiple
signaling
pathways,
AMP-activated
protein
kinase
(AMPK),
nuclear
factor
κB
(NF-κB),
mitogen-activated
silent
information
regulator
1
(SIRT-1),
hypoxia-inducible
1α
(HIF-1α),
endothelial
growth
phosphoinositide
3-kinase
(PI3K),
B
(Akt),
janus
2
(JAK-2),
Ca
2+
channels,
endoplasmic
reticulum
stress.
Moreover,
we
discuss
existing
limitations
give
corresponding
measures.
In
addition,
propose
some
research
perspectives
challenges,
provide
solid
base
from
which
further
can
excavate
effective
drugs
monomers.
Cells,
Год журнала:
2021,
Номер
10(9), С. 2341 - 2341
Опубликована: Сен. 7, 2021
The
endoplasmic
reticulum
(ER)
is
an
organelle
that
responsible
for
many
essential
subcellular
processes.
Interconnected
narrow
tubules
at
the
periphery
and
thicker
sheet-like
regions
in
perinuclear
region
are
linked
to
nuclear
envelope.
It
becoming
apparent
complex
morphology
dynamics
of
ER
its
function.
Mutations
proteins
involved
regulating
structure
movement
implicated
diseases
including
neurodegenerative
such
as
Alzheimer’s,
Parkinson’s,
amyotrophic
lateral
sclerosis
(ALS).
also
hijacked
by
pathogens
promote
their
replication.
Bacteria
Legionella
pneumophila
Chlamydia
trachomatis,
well
Zika
virus,
bind
dynamics-regulating
exploit
functions
advantage.
This
review
covers
our
understanding
morphology,
functional
subdomains
membrane
contact
sites
forms.
We
focus
on
current
efforts
quantify
motion
discuss
related
dynamics.
Endocrine Reviews,
Год журнала:
2021,
Номер
42(6), С. 839 - 871
Опубликована: Март 8, 2021
The
endoplasmic
reticulum
(ER)
hosts
linear
polypeptides
and
fosters
natural
folding
of
proteins
through
ER-residing
chaperones
enzymes.
Failure
the
ER
to
align
compose
proper
protein
architecture
leads
accumulation
misfolded/unfolded
in
lumen,
which
disturbs
homeostasis
provoke
stress.
Presence
stress
initiates
cytoprotective
unfolded
response
(UPR)
restore
or
instigates
a
rather
maladaptive
UPR
promote
cell
death.
Although
wide
array
cellular
processes
such
as
persistent
autophagy,
dysregulated
mitophagy,
secretion
proinflammatory
cytokines
may
contribute
onset
progression
cardiometabolic
diseases,
it
is
well
perceived
that
also
evokes
development
particularly
cardiovascular
diseases
(CVDs),
diabetes
mellitus,
obesity,
chronic
kidney
disease
(CKD).
Meanwhile,
these
pathological
conditions
further
aggravate
stress,
creating
vicious
cycle.
Here
this
review,
we
aimed
at
summarizing
updating
available
information
on
CVDs,
CKD,
hoping
offer
novel
insights
for
management
comorbidities
regulation
