Membranes,
Год журнала:
2025,
Номер
15(1), С. 9 - 9
Опубликована: Янв. 1, 2025
The
endoplasmic
reticulum
and
the
internal
nuclear
compartments
are
intrinsically
connected
through
membrane,
pores
lamina.
High
resolution
imaging
of
each
these
cellular
features
concurrently
remains
a
significant
challenge.
To
that
end
we
have
developed
new
molecular
membrane-endoplasmic
(NM-ER)
staining
fluorophore
with
emission
maxima
at
650
nm.
NM-ER
is
compatible
fixed
live
cell
stimulated
depletion
microscopy
(STED)
showing
improvement
in
when
compared
to
comparable
confocal
laser
scanning
microscopy.
versatility
was
illustrated
its
use
other
fluorophores
for
co-imaging
DNA,
lamina
allowing
abnormalities
be
identified.
alone,
or
region
labels
could
an
important
tool
investigation
transport
associated
processes.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(9)
Опубликована: Янв. 10, 2024
The
concept
of
molecular
design,
integrating
diagnostic
and
therapeutic
functions,
aligns
with
the
general
trend
modern
medical
advancement.
Herein,
we
rationally
designed
smart
molecule
ER-ZS
for
endoplasmic
reticulum
(ER)-targeted
diagnosis
treatment
in
cell
animal
models
by
combining
hemicyanine
dyes
ER-targeted
functional
groups
(p-toluenesulfonamide).
Owing
to
its
ability
target
ER
a
highly
specific
response
viscosity,
demonstrated
substantial
fluorescence
turn-on
only
after
binding
ER,
independent
other
physiological
environments.
In
addition,
ER-ZS,
being
small
molecule,
allows
nonalcoholic
fatty
liver
disease
(NAFLD)
via
imaging
based
on
high
stress.
Importantly,
is
type
I
photosensitizer,
producing
O
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(14), С. 7590 - 7631
Опубликована: Янв. 1, 2024
Golgi-specific
fluorescent
probes
provide
non-invasive,
real-time
and
in
situ
visualization
of
the
temporal
spatial
fluctuations
bioactive
species
enabling
effective
disease
monitoring
treatment.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(9)
Опубликована: Янв. 10, 2024
Abstract
The
concept
of
molecular
design,
integrating
diagnostic
and
therapeutic
functions,
aligns
with
the
general
trend
modern
medical
advancement.
Herein,
we
rationally
designed
smart
molecule
ER‐ZS
for
endoplasmic
reticulum
(ER)‐targeted
diagnosis
treatment
in
cell
animal
models
by
combining
hemicyanine
dyes
ER‐targeted
functional
groups
(
p
‐toluenesulfonamide).
Owing
to
its
ability
target
ER
a
highly
specific
response
viscosity,
demonstrated
substantial
fluorescence
turn‐on
only
after
binding
ER,
independent
other
physiological
environments.
In
addition,
,
being
small
molecule,
allows
nonalcoholic
fatty
liver
disease
(NAFLD)
via
imaging
based
on
high
stress.
Importantly,
is
type
I
photosensitizer,
producing
O
2
⋅
−
⋅OH
under
light
irradiation.
Thus,
irradiating
certain
period,
photodynamic
therapy
inflicted
severe
oxidative
damage
tumor
cells
hypoxic
(2
%
)
conditions
activated
unique
pyroptosis
pathway,
demonstrating
excellent
antitumor
capacity
xenograft
models.
Hence,
proposed
strategy
will
likely
shed
new
optics
NAFLD
cancer
therapy.
Chemical Communications,
Год журнала:
2023,
Номер
59(13), С. 1769 - 1772
Опубликована: Янв. 1, 2023
We
have
designed
and
synthesized
a
viscosity-sensitive,
far-red
emissive,
ER-selective,
molecular
rotor
probe
JER
to
monitor
the
ER
fate
during
ferroptosis
ER-phagy
processes.
