Acta Materia Medica,
Год журнала:
2023,
Номер
2(3)
Опубликована: Янв. 1, 2023
The
prevalence
of
age-related
diseases
has
been
progressively
increasing
worldwide.
pathogenesis
these
disorders,
including
cancer,
is
closely
associated
with
an
age-dependent
decline
in
cellular
functions.
There
are
multiple
layers
crosstalk
between
aging
processes
and
oncogenesis.
Therefore,
a
better
understanding
the
interplay
cancer
will
facilitate
development
novel
therapeutic
intervention
strategies
for
malignancies
at
advanced
ages.
Recent
review
articles
have
concisely
summarized
updated
hallmark
features
adequately
discussed
interplays
both
molecular
levels.
Because
share
several
key
mechanisms
that
define
hallmarks,
targeting
shared
features,
such
as
senescence,
may
be
beneficial
prevention
treatments.
Notably,
senolysis,
innovative
selectively
removing
senescent
cells,
holds
great
promise
developing
new
approaches
cancers
other
diseases,
viral
infections
cardiovascular
diseases.
Herein
we
briefly
summarize
recently
knowledge
on
well
advances
senolysis
conditions.
Abstract
Aging
and
cancer
exhibit
apparent
links
that
we
will
examine
in
this
review.
The
null
hypothesis
aging
coincide
because
both
are
driven
by
time,
irrespective
of
the
precise
causes,
can
be
confronted
with
idea
share
common
mechanistic
grounds
referred
to
as
‘hallmarks’.
Indeed,
several
hallmarks
also
contribute
carcinogenesis
tumor
progression,
but
some
molecular
cellular
characteristics
may
reduce
probability
developing
lethal
cancer,
perhaps
explaining
why
very
old
age
(>
90
years)
is
accompanied
a
reduced
incidence
neoplastic
diseases.
We
discuss
possibility
process
itself
causes
meaning
time-dependent
degradation
supracellular
functions
accompanies
produces
byproduct
or
‘age-associated
disease’.
Conversely,
its
treatment
erode
health
drive
process,
has
dramatically
been
documented
for
survivors
diagnosed
during
childhood,
adolescence,
young
adulthood.
conclude
connected
superior
including
endogenous
lifestyle
factors,
well
bidirectional
crosstalk,
together
render
not
only
risk
factor
an
important
parameter
must
considered
therapeutic
decisions.
Nature Cell Biology,
Год журнала:
2024,
Номер
26(9), С. 1571 - 1584
Опубликована: Авг. 8, 2024
Abstract
Caloric
restriction
and
intermittent
fasting
prolong
the
lifespan
healthspan
of
model
organisms
improve
human
health.
The
natural
polyamine
spermidine
has
been
similarly
linked
to
autophagy
enhancement,
geroprotection
reduced
incidence
cardiovascular
neurodegenerative
diseases
across
species
borders.
Here,
we
asked
whether
cellular
physiological
consequences
caloric
depend
on
metabolism.
We
report
that
levels
increased
upon
distinct
regimens
or
in
yeast,
flies,
mice
volunteers.
Genetic
pharmacological
blockade
endogenous
synthesis
fasting-induced
nematodes
cells.
Furthermore,
perturbing
pathway
vivo
abrogated
lifespan-
healthspan-extending
effects,
as
well
cardioprotective
anti-arthritic
fasting.
Mechanistically,
mediated
these
effects
via
induction
hypusination
translation
regulator
eIF5A.
In
summary,
polyamine–hypusination
axis
emerges
a
phylogenetically
conserved
metabolic
control
hub
for
fasting-mediated
enhancement
longevity.
The
inexorability
of
the
aging
process
has
sparked
curiosity
human
beings
since
ancient
times.
However,
despite
this
interest
and
extraordinary
scientific
advances
in
field,
complexity
hampered
its
comprehension.
In
context,
Hallmarks
Aging
were
defined
2013
with
aim
establishing
an
organized,
systematic
integrative
view
topic,
which
would
serve
as
a
conceptual
framework
for
research.
Ten
years
later
promoted
by
progress
area,
updated
version
included
three
new
hallmarks
while
maintaining
original
scope.
review
is
to
determine
what
extent
achieved
purpose
that
gave
rise
them.
For
aim,
we
have
reviewed
literature
citing
any
two
versions
conclude
they
served
not
only
research
but
also
related
areas
knowledge.
Finally,
discusses
candidates
become
part
list,
analyzing
evidence
supports
whether
should
or
be
incorporated.
JACC Asia,
Год журнала:
2024,
Номер
4(5), С. 345 - 358
Опубликована: Апрель 8, 2024
Cardiovascular
disease
(CVD)
has
increasing
challenges
for
human
health
with
an
increasingly
aging
population
worldwide,
imposing
a
significant
obstacle
to
the
goal
of
healthy
aging.
Rapid
advancements
in
our
understanding
biological
process
have
shed
new
light
on
some
important
insights
aging-related
diseases.
Although
numerous
reviews
delved
into
mechanisms
through
which
affects
CVD
and
age-related
diseases,
most
these
relied
heavily
research
related
cellular
molecular
processes
often
observed
from
animal
experiments.
Few
provided
that
connect
hypotheses
regarding
patterns
chronological
impacts
populations.
The
purpose
this
review
is
highlight
major
questions
studies
provide
perspectives
context
real-world
multidimensional
information
potential
insights.
Abstract
Cellular
senescence
and
the
senescence‐associated
secretory
phenotype
(SASP)
contribute
to
age‐related
arterial
dysfunction,
in
part,
by
promoting
oxidative
stress
inflammation,
which
reduce
bioavailability
of
vasodilatory
molecule
nitric
oxide
(NO).
In
present
study,
we
assessed
efficacy
fisetin,
a
natural
compound,
as
senolytic
vascular
cell
SASP
factors
improve
function
old
mice.
We
found
that
fisetin
decreased
cellular
human
endothelial
culture.
mice,
SASP‐related
inflammation
were
lower
1
week
after
final
dose
oral
intermittent
(1
on—2
weeks
off—1
on
dosing)
supplementation.
Old
fisetin‐supplemented
mice
had
higher
function.
Leveraging
p16‐3MR
transgenic
model
allowing
genetic
clearance
p16
INK4A
‐positive
senescent
cells,
ex
vivo
removal
cells
from
arteries
isolated
vehicle‐
but
not
fisetin‐treated
increased
endothelium‐dependent
dilation,
demonstrating
improved
through
senolysis.
Enhanced
with
was
mediated
NO
reduced
cellular‐
mitochondrial‐related
stress.
Arterial
stiffness
Ex
senolysis
aorta
rings
did
further
mechanical
wall
due
Lower
accompanied
favorable
remodeling.
The
findings
this
study
identify
promising
therapy
for
clinical
translation
target
excess
treat
dysfunction.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 1978 - 1978
Опубликована: Фев. 6, 2024
Endothelial
cells
line
at
the
most
inner
layer
of
blood
vessels.
They
act
to
control
hemostasis,
arterial
tone/reactivity,
wound
healing,
tissue
oxygen,
and
nutrient
supply.
With
age,
endothelial
become
senescent,
characterized
by
reduced
regeneration
capacity,
inflammation,
abnormal
secretory
profile.
senescence
represents
one
earliest
features
ageing
contributes
many
age-related
diseases.
Compared
those
in
arteries
veins,
microcirculation
exhibit
a
greater
extent
heterogeneity.
Microcirculatory
leads
declined
capillary
density,
angiogenic
potentials,
decreased
flow,
impaired
barrier
properties,
hypoperfusion
or
organ-dependent
manner.
The
heterogeneous
phenotypes
microvascular
particular
vascular
bed
across
different
tissues
remain
largely
unknown.
Accordingly,
mechanisms
underlying
macro-
micro-vascular
vary
pathophysiological
conditions,
thus
offering
specific
target(s)
for
therapeutic
development
senolytic
drugs.
Canadian Journal of Cardiology,
Год журнала:
2024,
Номер
40(8), С. 1445 - 1457
Опубликована: Фев. 12, 2024
Population
aging
and
the
associated
increase
in
cardiovascular
disease
rates
pose
serious
threats
to
global
public
health.
Different
forms
of
fasting
have
become
an
increasingly
attractive
strategy
directly
address
potentially
limit
or
delay
onset
diseases.
A
growing
number
experimental
studies
clinical
trials
indicate
that
amount
timing
food
intake
as
well
daily
time
window
during
which
is
consumed,
are
crucial
determinants
Indeed,
intermittent
counteracts
molecular
hallmarks
promotes
different
aspects
cardiometabolic
health,
including
blood
pressure
glycemic
control,
body
weight
reduction.
Here,
we
summarize
current
evidence
from
randomized
on
composition
metabolic
risk
factors.
Moreover,
critically
discuss
preventive
therapeutic
potential
fasting,
but
also
possible
detrimental
effects
context
related
disease.
We
delve
into
physiological
mechanisms
through
might
improve
raise
important
factors
consider
design
examining
efficacy
reduce
major
adverse
events
among
aged
individuals
at
high
conclude
despite
interest
both
lay
scientific
communities
health-improving
further
research
efforts
appropriate
caution
warranted
before
broadly
implementing
regimens,
especially
elderly.
