Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(43)
Опубликована: Сен. 1, 2022
Abstract
Crosslinking
plays
a
crucial
role
in
determining
mechanical
properties
of
polymer
materials.
Although
various
crosslinks
based
on
covalent
or
noncovalent
bonds
have
been
adopted,
it
remains
an
enormous
challenge
to
develop
crosslink
which
could
endow
corresponding
network
with
robust
yet
dynamic
properties.
Herein,
we
report
simultaneously
having
property
and
woven
geometry,
the
(WPN)
integrate
merits
(CPN)
supramolecular
(SPN).
In
specific,
WPN
not
only
exhibits
comparable
stiffness,
strength,
elastic
recovery,
anti‐fatigue
those
CPN,
but
also
possesses
decent
adaptivity
ductility,
similar
SPN.
Particularly,
its
toughness
puncture
resistance
are
much
superior
others.
Besides,
dynamicity
imparts
good
performances
self‐healing
processability
WPN.
Advanced Materials,
Год журнала:
2024,
Номер
36(25)
Опубликована: Март 22, 2024
Abstract
Recently,
hydrogel‐based
soft
materials
have
demonstrated
huge
potential
in
robotics,
flexible
electronics
as
well
artificial
skins.
Although
various
methods
are
developed
to
prepare
tough
and
strong
hydrogels,
it
is
still
challenging
simultaneously
enhance
the
strength
toughness
of
especially
for
protein‐based
hydrogels.
Herein,
a
biomimetic
“salting
out—alignment—locking”
tactic
(SALT)
introduced
enhancing
mechanical
properties
through
synergy
alignment
salting
out
effect.
As
typical
example,
tensile
modulus
initially
brittle
gelatin
hydrogels
increase
940
folds
10.12
±
0.50
MPa
2830
34.26
3.94
MPa,
respectively,
increases
up
1785
14.28
3.13
MJ
m
−3
.
The
obtained
hold
records
previously
reported
gelatin‐based
hydrogel
close
tendons.
It
further
elucidated
that
effect
engenders
hydrophobic
domains,
while
prestretching
facilitates
chain
alignment,
both
synergistically
contributing
outstanding
properties.
noteworthy
SALT
demonstrates
remarkable
versatility
across
different
salt
types
polymer
systems,
thus
opening
new
avenues
engineering
strong,
tough,
stiff
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(16), С. 7337 - 7345
Опубликована: Март 31, 2022
Biosynthesis
has
been
a
diverse
toolbox
to
develop
bioactive
molecules
and
materials,
especially
for
fabricating
modified
peptides
their
assemblies
induced
by
enzymes.
Although
desired
chemical
structures
nanoarchitectures
have
achieved,
the
subsequent
interferences
of
peptide
with
organelles
cellular
pathways
still
remain
unsolved
important
challenges.
Herein,
we
developed
new
tripeptide,
phenylalanine-phenylalanine-tyrosine
(Phe-Phe-Tyr,
or
FFY),
which
can
be
intracellularly
oxidized
in
situ
self-assemble
into
nanoparticles
excellent
interference
capability
microtubules
ultimately
reverse
drug
resistance
melanoma.
With
catalysis
tyrosinase,
FFY
was
first
melanin-like
dimer
(mFFY)
diquinone
structure
further
self-assembling
mFFY
assemblies,
could
inhibit
self-polymerization
tubulin
induce
severe
G2/M
arrest
(13.9%
higher
than
control).
Afterward,
mitochondrial
dysfunction
also
overproduction
cleaved
caspase
3
(3.1
times
control)
PARP
(6.3
higher),
achieving
high
level
resistant
reversing
without
chemotherapeutic
drugs.
In
vivo
studies
showed
that
melanoma
tumor
volumes
were
reduced
87.4%
compared
control
groups
after
treatment
peritumoral
injections.
Overall,
this
tyrosinase-induced
tripeptide
assembly
demonstrated
effective
intrinsic
apoptosis
against
drug-resistant
melanoma,
providing
insight
utilizing
biomolecules
interfere
activate
certain
cancer.
Advanced Materials,
Год журнала:
2024,
Номер
36(34)
Опубликована: Июнь 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
Materials,
Год журнала:
2024,
Номер
17(2), С. 456 - 456
Опубликована: Янв. 18, 2024
Biomaterials
embody
a
groundbreaking
paradigm
shift
in
the
field
of
drug
delivery
and
human
applications.
Their
versatility
adaptability
have
not
only
enriched
therapeutic
outcomes
but
also
significantly
reduced
burden
adverse
effects.
This
work
serves
as
comprehensive
overview
biomaterials,
with
particular
emphasis
on
their
pivotal
role
delivery,
classifying
them
terms
biobased,
biodegradable,
biocompatible
nature,
highlighting
characteristics
advantages.
The
examination
delves
into
extensive
array
applications
for
biomaterials
encompassing
diverse
medical
fields
such
cancer
therapy,
cardiovascular
diseases,
neurological
disorders,
vaccination.
explores
actual
challenges
within
this
domain,
including
potential
toxicity
complexity
manufacturing
processes.
These
emphasize
necessity
thorough
research
continuous
development
regulatory
frameworks.
second
aim
review
is
to
navigate
through
compelling
terrain
recent
advances
prospects
envisioning
healthcare
landscape
where
they
empower
precise,
targeted,
personalized
delivery.
transform
staggering,
promise
treatments
tailored
individual
patient
needs,
offering
hope
improved
efficacy,
fewer
side
effects,
brighter
future
practice.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(29), С. 35469 - 35482
Опубликована: Июль 18, 2023
Developing
a
new
generation
of
ecofriendly
water-based
polymeric
materials
that
integrate
mechanical
robustness,
fast
room-temperature
self-healing,
adhesive,
and
fluorescence
remains
formidable
challenge.
Herein,
inspired
by
titin
protein,
series
novel
waterborne
polyurethanes
(WPU-CHZ-NAGA)
containing
irregular
6-fold
diamide
hydrogen
bonds
are
synthesized
introducing
carbohydrazide
(CHZ)
N,N-bis(2-hydroxyethyl)-3-amino
propionyl
glycinamide
(HO-NAGA-OH)
groups.
The
representative
WPU-CHZ2-NAGA3
exhibits
outstanding
properties
(tensile
strength
36.58
MPa,
tearing
energy
81.2
kJ
m-2,
toughness
125.82
MJ
m-3)
self-healing
ability
with
the
aid
ethanol
(≥90%
within
8
h)
originated
from
hierarchical
bonds.
These
superior
to
those
most
reported
polymer
materials.
Benefiting
plentiful
bonds,
WPU
matrix
achieves
excellent
adhesive
without
heating
or
adding
curing
agents.
Interestingly,
film
emits
inherent
blue
due
aggregation-induced
emission
effect
tertiary
amine
groups,
its
potential
applications
in
information
encryption
anticounterfeiting
further
demonstrated.
Specially,
eutectic
gel
strain
sensor
is
also
fabricated
deep
solvent
simple
physical
blending
method,
which
can
be
used
monitor
movement
human
fingers
wrists
as
well
change
body
temperature.
In
summary,
this
work
provides
insight
into
design
synthesis
multifunctional
high
properties.
