Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 19, 2024
Synthetic
extracellular
matrix
(ECM)
mimics
that
can
recapitulate
the
complex
biochemical
and
mechanical
nature
of
native
tissues
are
needed
for
advanced
models
development
disease.
Biomedical
research
has
heavily
relied
on
use
animal-derived
biomaterials,
which
is
now
impeding
their
translational
potential
convoluting
biological
insights
gleaned
from
in
vitro
tissue
models.
Natural
hydrogels
have
long
served
as
a
convenient
effective
cell
culture
tool,
but
advances
materials
chemistry
fabrication
techniques
present
promising
new
avenues
creating
xenogenic-free
ECM
substitutes
appropriate
organotypic
microphysiological
systems.
However,
significant
challenges
remain
synthetic
matrices
approximate
structural
sophistication,
complexity,
dynamic
functionality
tissues.
This
review
summarizes
key
properties
ECM,
discusses
recent
approaches
used
to
systematically
decouple
tune
these
matrices.
The
importance
mechanics,
such
viscoelasticity
plasticity,
also
discussed,
particularly
within
context
organoid
engineered
Emerging
design
strategies
mimic
reviewed,
multi-network
hydrogels,
supramolecular
chemistry,
assembled
monomers.
Gels,
Год журнала:
2023,
Номер
9(11), С. 845 - 845
Опубликована: Окт. 25, 2023
AI
and
ML
have
emerged
as
transformative
tools
in
various
scientific
domains,
including
hydrogel
design.
This
work
explores
the
integration
of
techniques
realm
development,
highlighting
their
significance
enhancing
design,
characterisation,
optimisation
hydrogels
for
diverse
applications.
We
introduced
concept
train
underscoring
its
potential
to
decode
intricate
relationships
between
compositions,
structures,
properties
from
complex
data
sets.
In
this
work,
we
outlined
classical
physical
chemical
setting
stage
AI/ML
advancements.
These
methods
provide
a
foundational
understanding
subsequent
AI-driven
innovations.
Numerical
analytical
empowered
by
were
also
included.
computational
enable
predictive
simulations
behaviour
under
varying
conditions,
aiding
property
customisation.
emphasised
AI’s
impact,
elucidating
role
rapid
material
discovery,
precise
predictions,
optimal
like
neural
networks
support
vector
machines
that
expedite
pattern
recognition
modelling
using
vast
datasets,
advancing
formulation
discovery
are
presented.
ML’s
influence
on
revolutionised
design
expediting
optimising
properties,
reducing
costs,
enabling
technologies
address
pressing
healthcare
biomedical
challenges,
offering
innovative
solutions
drug
delivery,
tissue
engineering,
wound
healing,
more.
By
harmonising
insights
with
techniques,
researchers
can
unlock
unprecedented
potentials,
tailoring
Abstract
The
viscoelasticity
of
mechanically
sensitive
tissues
such
as
periodontal
ligaments
(PDLs)
is
key
in
maintaining
mechanical
homeostasis.
Unfortunately,
PDLs
easily
lose
(e.g.,
stress
relaxation)
during
periodontitis
or
dental
trauma,
which
disrupt
cell–extracellular
matrix
(ECM)
interactions
and
accelerates
tissue
damage.
Here,
Pluronic
F127
diacrylate
(F127DA)
hydrogels
with
PDL‐matched
relaxation
rates
high
elastic
moduli
are
developed.
hydrogel
modulated
without
chemical
cross‐linking
by
controlling
precursor
concentrations.
Under
cytomechanical
loading,
F127DA
fast
significantly
improved
the
fibrogenic
differentiation
potential
PDL
stem
cells
(PDLSCs),
while
cultured
on
various
exhibited
similar
potentials
limited
cell
spreading
traction
forces
under
static
conditions.
Mechanically,
faster‐relaxing
leveraged
loading
to
activate
PDLSC
mechanotransduction
upregulating
integrin–focal
adhesion
kinase
pathway
thus
cytoskeletal
rearrangement,
reinforcing
cell–ECM
interactions.
In
vivo
experiments
confirm
that
promoted
repair
reduced
abnormal
healing
root
resorption
ankyloses)
delayed
replantation
avulsed
teeth.
This
study
firstly
investigated
how
nonlinear
influences
fibrogenesis
PDLSCs
stimuli,
it
reveals
underlying
mechanobiology,
suggests
novel
strategies
for
regeneration.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июнь 17, 2024
Abstract
Microgels
prepared
from
natural
or
synthetic
hydrogel
materials
have
aroused
extensive
attention
as
multifunctional
cells
drug
carriers,
that
are
promising
for
tissue
engineering
and
regenerative
medicine.
can
also
be
aggregated
into
microporous
scaffolds,
promoting
cell
infiltration
proliferation
repair.
This
review
gives
an
overview
of
recent
developments
in
the
fabrication
techniques
applications
microgels.
A
series
conventional
novel
strategies
including
emulsification,
microfluidic,
lithography,
electrospray,
centrifugation,
gas-shearing,
three-dimensional
bioprinting,
etc.
discussed
depth.
The
characteristics
microgels
microgel-based
scaffolds
culture
delivery
elaborated
with
emphasis
on
advantages
these
carriers
therapy.
Additionally,
we
expound
ongoing
foreseeable
current
limitations
their
aggregate
field
biomedical
engineering.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
techniques.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 19, 2024
Synthetic
extracellular
matrix
(ECM)
mimics
that
can
recapitulate
the
complex
biochemical
and
mechanical
nature
of
native
tissues
are
needed
for
advanced
models
development
disease.
Biomedical
research
has
heavily
relied
on
use
animal-derived
biomaterials,
which
is
now
impeding
their
translational
potential
convoluting
biological
insights
gleaned
from
in
vitro
tissue
models.
Natural
hydrogels
have
long
served
as
a
convenient
effective
cell
culture
tool,
but
advances
materials
chemistry
fabrication
techniques
present
promising
new
avenues
creating
xenogenic-free
ECM
substitutes
appropriate
organotypic
microphysiological
systems.
However,
significant
challenges
remain
synthetic
matrices
approximate
structural
sophistication,
complexity,
dynamic
functionality
tissues.
This
review
summarizes
key
properties
ECM,
discusses
recent
approaches
used
to
systematically
decouple
tune
these
matrices.
The
importance
mechanics,
such
viscoelasticity
plasticity,
also
discussed,
particularly
within
context
organoid
engineered
Emerging
design
strategies
mimic
reviewed,
multi-network
hydrogels,
supramolecular
chemistry,
assembled
monomers.
