Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry DOI Creative Commons
Bram G. Soliman,

Ashley K. Nguyen,

J. Justin Gooding

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical and mechanical nature of native tissues are needed for advanced models development disease. Biomedical research has heavily relied on use animal-derived biomaterials, which is now impeding their translational potential convoluting biological insights gleaned from in vitro tissue models. Natural hydrogels have long served as a convenient effective cell culture tool, but advances materials chemistry fabrication techniques present promising new avenues creating xenogenic-free ECM substitutes appropriate organotypic microphysiological systems. However, significant challenges remain synthetic matrices approximate structural sophistication, complexity, dynamic functionality tissues. This review summarizes key properties ECM, discusses recent approaches used to systematically decouple tune these matrices. The importance mechanics, such viscoelasticity plasticity, also discussed, particularly within context organoid engineered Emerging design strategies mimic reviewed, multi-network hydrogels, supramolecular chemistry, assembled monomers.

Язык: Английский

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications DOI

Sravan Baddi,

Auphedeous Y. Dang-i,

Fengli Gao

и другие.

Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

4

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review DOI Creative Commons
Irina Neguț, Bogdan Biță

Gels, Год журнала: 2023, Номер 9(11), С. 845 - 845

Опубликована: Окт. 25, 2023

AI and ML have emerged as transformative tools in various scientific domains, including hydrogel design. This work explores the integration of techniques realm development, highlighting their significance enhancing design, characterisation, optimisation hydrogels for diverse applications. We introduced concept train underscoring its potential to decode intricate relationships between compositions, structures, properties from complex data sets. In this work, we outlined classical physical chemical setting stage AI/ML advancements. These methods provide a foundational understanding subsequent AI-driven innovations. Numerical analytical empowered by were also included. computational enable predictive simulations behaviour under varying conditions, aiding property customisation. emphasised AI’s impact, elucidating role rapid material discovery, precise predictions, optimal like neural networks support vector machines that expedite pattern recognition modelling using vast datasets, advancing formulation discovery are presented. ML’s influence on revolutionised design expediting optimising properties, reducing costs, enabling technologies address pressing healthcare biomedical challenges, offering innovative solutions drug delivery, tissue engineering, wound healing, more. By harmonising insights with techniques, researchers can unlock unprecedented potentials, tailoring

Язык: Английский

Процитировано

26

Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration DOI Creative Commons

Jiu‐Jiu Zhang,

Xuan Li, Yi Tian

и другие.

Advanced Science, Год журнала: 2024, Номер 11(18)

Опубликована: Март 9, 2024

Abstract The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose (e.g., stress relaxation) during periodontitis or dental trauma, which disrupt cell–extracellular matrix (ECM) interactions and accelerates tissue damage. Here, Pluronic F127 diacrylate (F127DA) hydrogels with PDL‐matched relaxation rates high elastic moduli are developed. hydrogel modulated without chemical cross‐linking by controlling precursor concentrations. Under cytomechanical loading, F127DA fast significantly improved the fibrogenic differentiation potential PDL stem cells (PDLSCs), while cultured on various exhibited similar potentials limited cell spreading traction forces under static conditions. Mechanically, faster‐relaxing leveraged loading to activate PDLSC mechanotransduction upregulating integrin–focal adhesion kinase pathway thus cytoskeletal rearrangement, reinforcing cell–ECM interactions. In vivo experiments confirm that promoted repair reduced abnormal healing root resorption ankyloses) delayed replantation avulsed teeth. This study firstly investigated how nonlinear influences fibrogenesis PDLSCs stimuli, it reveals underlying mechanobiology, suggests novel strategies for regeneration.

Язык: Английский

Процитировано

17

Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine DOI Creative Commons

L. Le Xuan,

Yingying Hou, Lu Liang

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июнь 17, 2024

Abstract Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells drug carriers, that are promising for tissue engineering and regenerative medicine. can also be aggregated into microporous scaffolds, promoting cell infiltration proliferation repair. This review gives an overview of recent developments in the fabrication techniques applications microgels. A series conventional novel strategies including emulsification, microfluidic, lithography, electrospray, centrifugation, gas-shearing, three-dimensional bioprinting, etc. discussed depth. The characteristics microgels microgel-based scaffolds culture delivery elaborated with emphasis on advantages these carriers therapy. Additionally, we expound ongoing foreseeable current limitations their aggregate field biomedical engineering. Through stimulating innovative ideas, present paves new avenues expanding application techniques.

Язык: Английский

Процитировано

17

Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry DOI Creative Commons
Bram G. Soliman,

Ashley K. Nguyen,

J. Justin Gooding

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical and mechanical nature of native tissues are needed for advanced models development disease. Biomedical research has heavily relied on use animal-derived biomaterials, which is now impeding their translational potential convoluting biological insights gleaned from in vitro tissue models. Natural hydrogels have long served as a convenient effective cell culture tool, but advances materials chemistry fabrication techniques present promising new avenues creating xenogenic-free ECM substitutes appropriate organotypic microphysiological systems. However, significant challenges remain synthetic matrices approximate structural sophistication, complexity, dynamic functionality tissues. This review summarizes key properties ECM, discusses recent approaches used to systematically decouple tune these matrices. The importance mechanics, such viscoelasticity plasticity, also discussed, particularly within context organoid engineered Emerging design strategies mimic reviewed, multi-network hydrogels, supramolecular chemistry, assembled monomers.

Язык: Английский

Процитировано

16