Disulfide-bonded
peptides
and
proteins,
including
hormones,
toxins,
growth
factors,
others,
are
abundant
in
living
organisms.
These
molecules
play
crucial
physiological
roles
such
as
regulating
cell
organism
growth,
development,
metabolism.
They
have
also
found
widespread
applications
drugs
or
tool
biomedical
pharmaceutical
research.
However,
the
chemical
synthesis
of
disulfide-bonded
proteins
is
complicated
by
challenges
associated
with
their
folding.
This
review
focuses
on
latest
advancements
peptide
protein
folding
technologies.
Particularly,
it
highlights
biomimetic
strategies
that
emulate
naturally
occurring
oxidative
processes
nature.
include
chaperone-assisted
folding,
glycosylation-assisted
organic-based
methods.
The
anticipates
future
directions
technology.
Such
research
offers
innovative
approaches
for
complex
otherwise
difficult
to
fold.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Imidazoheterocycles
have
extensive
applications
in
the
pharmaceutical
industry
and
agrochemicals.
A
comprehensive
overview
has
been
provided
on
current
advancements
electrochemical
functionalization
of
imidazo‐fused
heterocycles,
which
classified
into
ten
different
types
reactions.
Electrochemical
synthesis
emerged
as
a
highly
effective
method
for
producing
organic
molecules,
especially
context
sustainable
development.
Employing
electrons
traceless
oxidant,
several
C−H
reactions
heterocycles
achieved
at
either
C3
or
C5
positions.
Electrons
may
serve
reducing
agent
to
synthesize
pyridine
rings
that
are
partially
fully
saturated
imidazo[1,2‐
]pyridines.
The
purpose
review
is
attract
interest
scientific
community
promote
additional
research
imidazoheterocycles
using
methods.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(46), С. 63170 - 63185
Опубликована: Ноя. 8, 2024
Spinal
cord
injury
(SCI)
is
a
serious
neurological
disease
that
can
result
in
paralysis.
After
SCI
occurs,
the
blood–spinal
barrier
(BSCB)
disrupted,
and
permeability
transiently
elevated.
However,
of
BSCB
returns
to
normal
over
time,
which
prevents
many
drugs
from
being
used
subsequent
treatments.
In
this
study,
we
designed
borneol-functionalized
macrophage
membrane
encapsulating
mesoporous
selenium
nanoparticles
loaded
with
resveratrol
(MSe-Res-BMMs)
for
treatment.
vivo
animal
experiments
vitro
cell
demonstrated
MSe-Res-BMMs
were
able
protect
neurons
ferroptosis
by
reducing
ROS
levels
increasing
glutathione
peroxidase-4
(GPx-4)
activity.
addition,
treatment
also
reduced
ROS-induced
inflammation
apoptosis
decreasing
expression
inflammatory
factor
IL-1β
apoptotic
Cleaved
Caspase-3
at
site
injury.
Therefore,
are
expected
provide
new
therapeutic
options
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Triple-negative
breast
cancer
(TNBC)
is
one
of
the
most
aggressive
and
challenging
subtypes
with
limited
treatment
options
poor
prognosis.
To
overcome
these
obstacles,
Ag-doped
SnSe
(ASS)
nanosheets
were
used
as
photonic
hyperthermia
agents
for
treating
TNBC.
ASS
featured
a
high
photothermal-conversion
efficiency
photon
effect.
Additionally,
biosafety
assessments,
including
hemolysis
assays
histopathological
analysis,
confirmed
that
was
biosafety.
These
findings
suggest
ASS,
in
synergy
second
near-infrared
biowindow
(NIR-II)
light
irradiation,
offers
noninvasive,
effective,
safe
therapeutic
strategy
This
innovative
approach
exemplifies
evolving
landscape
TNBC
treatment,
where
technology
biology
converge
to
offer
more
precise
personalized
therapies.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(49)
Опубликована: Авг. 12, 2024
Abstract
Antisense
oligonucleotide
(ASO)
therapies
hold
significant
promise
in
the
realm
of
molecular
medicine.
By
precisely
targeting
RNA
molecules,
ASOs
offer
an
approach
to
modulate
gene
expression
and
protein
production,
making
them
valuable
tools
for
treating
a
wide
range
genetic
acquired
diseases.
As
precise
intracellular
delivery
is
challenging,
strategies
preparing
ASO‐ligand
conjugates
are
exceedingly
high
demand.
This
work
leverages
utility
native
chemical
ligation
conjugate
with
therapeutically
relevant
modifications
including
locked
nucleic
acids
phosphorothioate
backbone
peptides
sugars
via
stable
amide
linkage.
A
suite
post‐ligation
functionalizations
through
modification
cysteine
handle
highlighted,
chemoselective
radical
desulfurization,
lipidation,
alkylation
handles
(e.g.
alkyne,
biotin,
radionuclide
chelating
ligands),
affording
multifunctional
constructs
further
applications
biology
Application
methodology
clinically‐relevant
triantennary‐GalNAc
ASO
validation
its
binding
functional
activity
underpins
applicability
technique
oligonucleotide‐based
therapeutics.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 25, 2024
Abstract
Catalytic
methods
for
amide
and
peptide
synthesis
have
long
been
recognized
as
one
of
the
most
pressing
challenges
in
industry
academia,
requiring
novel
catalysts
to
meet
this
requirement.
Herein,
we
report
an
organocatalyst,
named
Cat-Se,
direct
synthesis.
which
has
a
simple
exquisite
chemical
structure,
can
be
conveniently
synthesized
catalyzes
condensation
various
carboxylic
acids
amines
corresponding
amides
excellent
yields
within
30-40
minutes
under
very
mild
light
irradiation
conditions
without
any
undesirable
operations,
such
heating,
dehydration,
or
gas
protection.
The
method
exhibits
high
efficiency,
selectivity,
functional
group
tolerance
loss
stereochemical
integrity
Significantly,
Cat-Se
shows
power
fragment
solid-phase
on
resin,
making
it
attractive
alternative
drug
Disulfide-bonded
peptides
and
proteins,
including
hormones,
toxins,
growth
factors,
others,
are
abundant
in
living
organisms.
These
molecules
play
crucial
physiological
roles
such
as
regulating
cell
organism
growth,
development,
metabolism.
They
have
also
found
widespread
applications
drugs
or
tool
biomedical
pharmaceutical
research.
However,
the
chemical
synthesis
of
disulfide-bonded
proteins
is
complicated
by
challenges
associated
with
their
folding.
This
review
focuses
on
latest
advancements
peptide
protein
folding
technologies.
Particularly,
it
highlights
biomimetic
strategies
that
emulate
naturally
occurring
oxidative
processes
nature.
include
chaperone-assisted
folding,
glycosylation-assisted
organic-based
methods.
The
anticipates
future
directions
technology.
Such
research
offers
innovative
approaches
for
complex
otherwise
difficult
to
fold.
