Global and East Asia tracheal, bronchus, and lung cancer trend analysis from 1990 to 2021 and forecast trend from 2021 to 2035 DOI Creative Commons
Jian Ding,

Weizhen Guo,

Qian Xue

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 13, 2025

Background and Aims This study aimed to evaluate the trends in incidence, mortality, disability-adjusted life years (DALYs) for trachea, bronchus, lung (TBL) cancer globally East Asia from 1990 2021. Methods We analyzed TBL data Global Burden of Disease (GBD) 2021 study, focusing on five Asian countries. Socioeconomic contexts were examined using sociodemographic indices. Trends disease metrics time-segmented link-point regression determine average annual percentage change (AAPC). A Bayesian Age-Period-Cohort (BAPC) model was applied forecast future burden 2022 2030. Results Globally Asia, significant increases observed DALYs related China had highest rates incidence (934,704; 95% UI, 750,040 1,136,938), mortality (814,364; 652,636 987,795), (18,920,203; 15,100,681 23,111,519), while Mongolia lowest. Ambient particulate matter pollution identified as main risk factor both most Notably, global spikes occurred during 1999-2012 2019-2021 (AAPC: 1.170 [95%, 1.115 1.225] 1.658 0.604 2.723], respectively). In Mongolia, showed variable trends. The DALY attributed population aging growth, epidemiological shifts have contributed reduced rates. Except Democratic People’s Republic Korea, generally declining across other Conclusion There has been a increase 2021, with environmental potentially serving strongly correlated factor. is an urgent need enhance prevention, early detection, treatment measures, particularly high-risk regions.

Язык: Английский

Cancer statistics, 2025 DOI Open Access

Rebecca L. Siegel,

Tyler B. Kratzer, Angela N. Giaquinto

и другие.

CA A Cancer Journal for Clinicians, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

ABSTRACT Each year, the American Cancer Society estimates numbers of new cancer cases and deaths in United States compiles most recent data on population‐based occurrence outcomes using incidence collected by central registries (through 2021) mortality National Center for Health Statistics 2022). In 2025, 2,041,910 618,120 are projected to occur States. The rate continued decline through 2022, averting nearly 4.5 million since 1991 because smoking reductions, earlier detection some cancers, improved treatment. Yet alarming disparities persist; Native people bear highest mortality, including rates that two three times those White kidney, liver, stomach, cervical cancers. Similarly, Black have two‐fold higher than prostate, uterine corpus Overall has generally declined men but risen women, narrowing male‐to‐female ratio (RR) from a peak 1.6 (95% confidence interval, 1.57–1.61) 1992 1.1 1.12–1.12) 2021. However, women aged 50–64 years already surpassed (832.5 vs. 830.6 per 100,000), younger (younger 50 years) an 82% their male counterparts (141.1 77.4 up 51% 2002. Notably, lung among 65 2021 (15.7 15.4 100,000; RR, 0.98, p = 0.03). summary, continues decline, future gains threatened rampant racial inequalities growing burden disease middle‐aged young adults, especially women. Continued progress will require investment prevention access equitable treatment, individuals.

Язык: Английский

Процитировано

122
Non-small-cell lung cancer DOI
Lizza Hendriks, Jordi Remón, C. Faivre‐Finn

и другие.

Nature Reviews Disease Primers, Год журнала: 2024, Номер 10(1)

Опубликована: Сен. 26, 2024

Язык: Английский

Процитировано

43
Global, regional, and national burden of tracheal, bronchus, and lung cancer and its risk factors from 1990 to 2021: findings from the global burden of disease study 2021 DOI Creative Commons

Ziyu Kuang,

Jiaxi Wang, Kexin Liu

и другие.

EClinicalMedicine, Год журнала: 2024, Номер 75, С. 102804 - 102804

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

27
Estimated worldwide variation and trends in incidence of lung cancer by histological subtype in 2022 and over time: a population-based study DOI
Ganfeng Luo, Yanting Zhang, Harriet Rumgay

и другие.

The Lancet Respiratory Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Metagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early‐Stage Nonsmoking Lung Adenocarcinoma Patients DOI Creative Commons
Yaohui Sun,

Zhiming Gan,

Shijiancong Liu

и другие.

Thoracic Cancer, Год журнала: 2025, Номер 16(2)

Опубликована: Янв. 1, 2025

ABSTRACT Background The mycobiome in the tumor microenvironment of non‐smokers with early‐stage lung adenocarcinoma (ES‐LUAD) has been minimally investigated. Methods In this study, we conducted ultra‐deep metagenomic and transcriptomic sequencing on 128 samples collected from 46 nonsmoking ES‐LUAD patients 41 healthy controls (HC), aiming to characterize tumor‐resident its interactions host. Results results revealed that exhibited fungal dysbiosis characterized by reduced species diversity significant imbalances specific abundances. Concurrently, microbial functional analysis alterations associated genes such as ribosomal proteins histones. We observed correlations between Yarrowia lipolytica , Saccharomyces paradoxus tumor‐infiltrating immune cells (TIICs), identified a strong association (|rho| > 0.7) S. 14 transcription factors. A signature three prognostic (GRIA1, CDO1, FHL1) closely was they suggest interaction host may contribute prolonged overall survival (OS). Finally, predictive model based six fungi demonstrated decent classification performance distinguishing cases HCs (AUC = 0.724). Conclusions Our study demonstrates transcriptome within tumors help elucidate pathogenic mechanisms ES‐LUAD. Fungi, potential tool, can be used an additional resource for accurately detecting discriminating individuals

Язык: Английский

Процитировано

1
Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy DOI Creative Commons
Brian S. Henick, Alison Taylor, Hiroshi Nakagawa

и другие.

Cancer Cell, Год журнала: 2025, Номер 43(2), С. 178 - 194

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications DOI Creative Commons
Chi‐Yuan Chen, Kuo‐Yen Huang, Chih‐Cheng Chen

и другие.

EMBO Molecular Medicine, Год журнала: 2024, Номер 17(1), С. 31 - 40

Опубликована: Ноя. 22, 2024

Язык: Английский

Процитировано

5
Disparities in global disease burden attributed to ambient particulate matter pollution and household air pollution from solid fuels DOI Creative Commons

Qiao Liu,

Dun Li, Zhe Xu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117908 - 117908

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
circFOXK2 Stabilizes STMN1 mRNA via PABPC1 to Promote the Progression of NSCLC DOI Creative Commons
Wei Chen, Weijun Zhao,

Xianqiao Wu

и другие.

Cancer Medicine, Год журнала: 2025, Номер 14(5)

Опубликована: Фев. 27, 2025

Lung cancer has a notably high incidence and mortality rate, understanding its occurrence development is crucial for effective treatment. Circular RNA closely associated with tumor progression, playing role in tumorigenesis by regulating gene expression influencing cell proliferation apoptosis. This study aims to explore the circFOXK2 NSCLC elucidate underlying mechanisms. qRT-PCR Western Blot analyzed expressions of circFOXK2, STMN1, PABPCA lines, as well their relationships. The roles STMN1 proliferation, invasion, migration cells were assessed through CCK8, EDU, Transwell experiments. pulldown assays mass spectrometry elucidated RNA-binding proteins circFOXK2. Subcutaneous tail vein lung metastasis experiments impact on growth vivo. In this study, we identified which significantly overexpressed NSCLC, bioinformatics screening. Elevated levels enhance cells. Furthermore, such co-IP spectrometry, found that interacts PABPC1 form complex, correlates positively progression tumors. Simultaneously, circFOXK2/PABPC1 complex increases stability mRNA, thereby promoting transcription translation STMN1. Our experimental results indicate oncogenic effect requires assistance summary, have demonstrated significant NSCLC.

Язык: Английский

Процитировано

0
Association Between Depression and Lung Cancer Risk Among Postmenopausal Women DOI Creative Commons
Yuanyuan La, Su Yon Jung, Xiaoyun Liang

и другие.

Cancer Medicine, Год журнала: 2025, Номер 14(5)

Опубликована: Март 1, 2025

In recent years, the association between depression and various chronic diseases has attracted widespread attention. However, effect of on lung cancer incidence not been well studied. This study aimed to explore whether increases analyze mediating moderating roles smoking in this relationship. used large-scale longitudinal data sourced from Women's Health Initiative, encompassing 123,961 postmenopausal women. Depressive symptoms were measured using 8-item Burnam regression algorithm with a cut-point 0.06, was defined as either depressive or antidepressant use at baseline. The relationship examined multivariate Cox proportional hazards model. A four-way decomposition causal mediation approach employed investigate potential effects smoking. After mean follow-up 17.6 3434 cases identified. rate higher among individuals compared those without (HR: 1.15, 95% CI: 1.05-1.26). Cigarette partially mediated incidence, explaining about 27% effect. identified significant mediates highlights that managing may play key role reducing risk decreasing tobacco use. Psychological support should be integrated traditional cessation programs for prevention.

Язык: Английский

Процитировано

0