Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 24, 2023
Lung
cancer
is
one
of
the
common
malignant
cancers
worldwide.
Immune
checkpoint
inhibitor
(ICI)
therapy
has
improved
survival
lung
patients.
However,
ICI
leads
to
adaptive
immune
resistance
and
displays
PD-1/PD-L1
blockade
in
cancer,
leading
less
response
Tumor
microenvironment
(TME)
an
integral
tumor
microenvironment,
which
involved
immunotherapy
resistance.
Nanomedicine
been
used
enhance
cancer.
In
this
review
article,
we
described
association
between
TME
We
also
highlighted
importance
Moreover,
discussed
how
nanoparticles
are
regulation
improve
efficacy
immunotherapy,
including
SGT-53,
AZD1080,
Nanomodulator
NRF2,
Cisplatin
nanoparticles,
Au@PG,
DPAICP@ME,
SPIO
NP@M-P,
NBTXR3
ARAC
Nano-DOX,
MS
NPs,
Nab-paclitaxel,
GNPs-hPD-L1
siRNA.
Furthermore,
concluded
that
targeting
by
could
be
helpful
overcome
Dendritic
cell
(DC)-based
vaccination
for
cancer
treatment
has
seen
considerable
development
over
recent
decades.
However,
this
field
is
currently
in
a
state
of
flux
toward
niche-applications,
owing
to
paradigm-shifts
immuno-oncology
mobilized
by
T
cell-targeting
immunotherapies.
DC
vaccines
are
typically
generated
using
autologous
(patient-derived)
DCs
exposed
tumor-associated
or
-specific
antigens
(TAAs
TSAs),
the
presence
immunostimulatory
molecules
induce
maturation,
followed
reinfusion
into
patients.
Accordingly,
can
TAA/TSA-specific
CD8+/CD4+
responses.
Yet,
still
shows
suboptimal
anti-tumor
efficacy
clinic.
Extensive
efforts
ongoing
improve
immunogenicity
and
vaccines,
often
employing
combinatorial
chemo-immunotherapy
regimens.
In
Trial
Watch,
we
summarize
preclinical
clinical
developments
discuss
trends
future
perspectives
DC-based
immunotherapy
oncological
indications.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июнь 26, 2023
Abstract
Exosomal
circRNA
serves
a
novel
genetic
information
molecule,
facilitating
communication
between
tumor
cells
and
microenvironmental
cells,
such
as
immune
fibroblasts,
other
components,
thereby
regulating
critical
aspects
of
cancer
progression
including
escape,
angiogenesis,
metabolism,
drug
resistance,
proliferation
metastasis.
Interestingly,
microenvironment
have
new
findings
in
influencing
escape
mediated
by
the
release
exosomal
circRNA.
Given
intrinsic
stability,
abundance,
broad
distribution
circRNAs,
they
represent
excellent
diagnostic
prognostic
biomarkers
for
liquid
biopsy.
Moreover,
artificially
synthesized
circRNAs
may
open
up
possibilities
therapy,
potentially
bolstered
nanoparticles
or
plant
exosome
delivery
strategies.
In
this
review,
we
summarize
functions
underlying
mechanisms
cell
non-tumor
cell-derived
progression,
with
special
focus
on
their
roles
immunity
metabolism.
Finally,
examine
potential
application
therapeutic
targets,
highlighting
promise
clinical
use.
Cancer Discovery,
Год журнала:
2023,
Номер
13(7), С. 1521 - 1545
Опубликована: Апрель 7, 2023
Genomic
stability
in
normal
cells
is
crucial
to
avoid
oncogenesis.
Accordingly,
multiple
components
of
the
DNA
damage
response
(DDR)
operate
as
bona
fide
tumor
suppressor
proteins
by
preserving
genomic
stability,
eliciting
demise
with
unrepairable
lesions,
and
engaging
cell-extrinsic
oncosuppression
via
immunosurveillance.
That
said,
DDR
sig-naling
can
also
favor
progression
resistance
therapy.
Indeed,
signaling
cancer
has
been
consistently
linked
inhibition
tumor-targeting
immune
responses.
Here,
we
discuss
complex
interactions
between
inflammation
context
oncogenesis,
progression,
Accumulating
preclinical
clinical
evidence
indicates
that
intimately
connected
emission
immunomodulatory
signals
malignant
cells,
part
a
program
preserve
organismal
homeostasis.
DDR-driven
inflammation,
however,
have
diametrically
opposed
effects
on
immunity.
Understanding
links
may
unlock
novel
immunotherapeutic
paradigms
treat
cancer.
Immunological Reviews,
Год журнала:
2023,
Номер
321(1), С. 115 - 127
Опубликована: Сен. 4, 2023
Type
I
interferon
(IFN)
is
a
class
of
proinflammatory
cytokines
with
dual
role
on
malignant
transformation,
tumor
progression,
and
response
to
therapy.
On
the
one
hand,
robust,
acute,
resolving
type
IFN
responses
have
been
shown
mediate
prominent
anticancer
effects,
reflecting
not
only
their
direct
cytostatic/cytotoxic
activity
(at
least
some)
cells,
but
also
pronounced
immunostimulatory
functions.
In
line
this
notion,
signaling
has
implicated
in
antineoplastic
effects
various
immunogenic
therapeutics,
including
(but
limited
to)
cell
death
(ICD)-inducing
agents
immune
checkpoint
inhibitors
(ICIs).
other
weak,
indolent,
non-resolving
demonstrated
support
progression
resistance
therapy,
ability
suboptimal
cytoprotective
activity,
promote
stemness,
favor
tolerance
chromosomal
instability,
facilitate
establishment
an
immunologically
exhausted
microenvironment.
Here,
we
review
fundamental
aspects
context-dependent
impact
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 2, 2024
Abstract
Metastasis
remains
a
pivotal
characteristic
of
cancer
and
is
the
primary
contributor
to
cancer-associated
mortality.
Despite
its
significance,
mechanisms
governing
metastasis
are
not
fully
elucidated.
Contemporary
findings
in
domain
biology
have
shed
light
on
molecular
aspects
this
intricate
process.
Tumor
cells
undergoing
invasion
engage
with
other
cellular
entities
proteins
en
route
their
destination.
Insights
into
these
engagements
enhanced
our
comprehension
principles
directing
movement
adaptability
metastatic
cells.
The
tumor
microenvironment
plays
role
facilitating
proliferation
by
enabling
navigate
through
stromal
barriers.
Such
attributes
influenced
genetic
epigenetic
changes
occurring
surrounding
milieu.
A
profound
understanding
process’s
biological
indispensable
for
devising
efficacious
therapeutic
strategies.
This
review
delves
recent
developments
concerning
metastasis-associated
genes,
important
signaling
pathways,
microenvironment,
metabolic
processes,
peripheral
immunity,
mechanical
forces
metastasis.
In
addition,
we
combine
advances
particular
emphasis
prospect
developing
effective
interventions
including
most
popular
immunotherapies
nanotechnology
combat
We
also
identified
limitations
current
research
metastasis,
encompassing
drug
resistance,
restricted
animal
models,
inadequate
biomarkers
early
detection
methods,
as
well
heterogeneity
among
others.
It
anticipated
that
comprehensive
will
significantly
contribute
advancement
research.
