Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(3), С. 1987 - 2026
Опубликована: Март 2, 2024
Mitochondria
are
thought
to
have
become
incorporated
within
the
eukaryotic
cell
approximately
2
billion
years
ago
and
play
a
role
in
variety
of
cellular
processes,
such
as
energy
production,
calcium
buffering
homeostasis,
steroid
synthesis,
growth,
apoptosis,
well
inflammation
ROS
production.
Considering
that
mitochondria
involved
multitude
mitochondrial
dysfunction
has
been
shown
several
age-related
diseases,
including
cancers,
diabetes
(type
2),
neurodegenerative
although
underlying
mechanisms
not
entirely
understood.
The
significant
increase
lifespan
increased
incidence
diseases
over
recent
decades
confirmed
necessity
understand
by
which
impacts
process
aging
diseases.
In
this
review,
we
will
offer
brief
overview
mitochondria,
along
with
structure
function
important
organelle.
We
then
discuss
cause
consequence
process,
particular
focus
on
its
inflammation,
cognitive
decline,
Huntington’s
disease,
Parkinson’s
Alzheimer’s
disease.
insight
into
therapies
interventions
currently
used
preserve
or
restore
functioning
during
neurodegeneration.
Cell Metabolism,
Год журнала:
2022,
Номер
34(11), С. 1620 - 1653
Опубликована: Ноя. 1, 2022
The
analogy
of
mitochondria
as
powerhouses
has
expired.
Mitochondria
are
living,
dynamic,
maternally
inherited,
energy-transforming,
biosynthetic,
and
signaling
organelles
that
actively
transduce
biological
information.
We
argue
the
processor
cell,
together
with
nucleus
other
they
constitute
mitochondrial
information
processing
system
(MIPS).
In
a
three-step
process,
(1)
sense
respond
to
both
endogenous
environmental
inputs
through
morphological
functional
remodeling;
(2)
integrate
network-based
physical
interactions
diffusion
mechanisms;
(3)
produce
output
signals
tune
functions
systemically
regulate
physiology.
This
input-to-output
transformation
allows
metabolic,
biochemical,
neuroendocrine,
local
or
systemic
enhance
organismal
adaptation.
An
explicit
focus
on
signal
transduction
emphasizes
role
communication
in
biology.
framework
also
opens
new
avenues
understand
how
mediate
inter-organ
processes
underlying
human
health.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Май 15, 2024
Abstract
Mitochondria,
with
their
intricate
networks
of
functions
and
information
processing,
are
pivotal
in
both
health
regulation
disease
progression.
Particularly,
mitochondrial
dysfunctions
identified
many
common
pathologies,
including
cardiovascular
diseases,
neurodegeneration,
metabolic
syndrome,
cancer.
However,
the
multifaceted
nature
elusive
phenotypic
threshold
dysfunction
complicate
our
understanding
contributions
to
diseases.
Nonetheless,
these
complexities
do
not
prevent
mitochondria
from
being
among
most
important
therapeutic
targets.
In
recent
years,
strategies
targeting
have
continuously
emerged
transitioned
clinical
trials.
Advanced
intervention
such
as
using
healthy
replenish
or
replace
damaged
mitochondria,
has
shown
promise
preclinical
trials
various
Mitochondrial
components,
mtDNA,
mitochondria-located
microRNA,
associated
proteins
can
be
potential
agents
augment
function
immunometabolic
diseases
tissue
injuries.
Here,
we
review
current
knowledge
pathophysiology
concrete
examples
We
also
summarize
treat
perspective
dietary
supplements
targeted
therapies,
well
translational
situation
related
pharmacology
agents.
Finally,
this
discusses
innovations
applications
transplantation
an
advanced
promising
treatment.
Journal of Clinical Investigation,
Год журнала:
2023,
Номер
133(4)
Опубликована: Фев. 14, 2023
Kidney
disease
is
a
major
driver
of
mortality
among
patients
with
diabetes
and
diabetic
kidney
(DKD)
responsible
for
close
to
half
all
chronic
cases.
DKD
usually
develops
in
genetically
susceptible
individual
as
result
poor
metabolic
(glycemic)
control.
Molecular
genetic
studies
indicate
the
key
role
podocytes
endothelial
cells
driving
albuminuria
early
diabetes.
Proximal
tubule
changes
show
strong
association
glomerular
filtration
rate.
Hyperglycemia
represents
cellular
stress
by
altering
metabolism
imposing
an
excess
workload
requiring
energy
oxygen
proximal
cells.
Changes
induce
adaptive
hypertrophy
reorganization
actin
cytoskeleton.
Later,
mitochondrial
defects
contribute
increased
oxidative
activation
inflammatory
pathways,
causing
progressive
function
decline
fibrosis.
Blockade
renin-angiotensin
system
or
sodium-glucose
cotransporter
associated
protection
slowing
decline.
Newly
identified
molecular
pathways
could
provide
basis
development
much-needed
novel
therapeutics.
Journal of Biomedical Science,
Год журнала:
2022,
Номер
29(1)
Опубликована: Сен. 26, 2022
The
major
concept
of
"oxidative
stress"
is
an
excess
elevated
level
reactive
oxygen
species
(ROS)
which
are
generated
from
vigorous
metabolism
and
consumption
oxygen.
precise
harmonization
oxidative
stresses
between
mitochondria
other
organelles
in
the
cell
absolutely
vital
to
survival.
Under
stress,
ROS
produced
mediator
for
tumorigenesis
different
aspects,
such
as
proliferation,
migration/invasion,
angiogenesis,
inflammation,
immunoescape
allow
cancer
cells
adapt
rigorous
environment.
Accordingly,
dynamic
balance
not
only
orchestrate
complex
signaling
events
but
also
affect
components
tumor
microenvironment
(TME).
Immune
cells,
M2
macrophages,
dendritic
T
immunosuppressive
TME
ROS-induced
inflammation.
Based
on
this
notion,
numerous
strategies
mitigate
tumors
have
been
tested
prevention
or
therapies;
however,
these
manipulations
devised
sources
mechanisms
without
established
effectiveness.
Herein,
we
integrate
current
progress
regarding
impact
mitochondrial
TME,
immune
discuss
combination
emerging
ROS-modulating
with
immunotherapies
achieve
antitumor
effects.
Molecular Metabolism,
Год журнала:
2023,
Номер
74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Cell,
Год журнала:
2023,
Номер
186(14), С. 3013 - 3032.e22
Опубликована: Июнь 22, 2023
Mitochondrial
DNA
(mtDNA)
is
a
potent
agonist
of
the
innate
immune
system;
however,
exact
immunostimulatory
features
mtDNA
and
kinetics
detection
by
cytosolic
nucleic
acid
sensors
remain
poorly
defined.
Here,
we
show
that
mitochondrial
genome
instability
promotes
Z-form
accumulation.
Z-DNA
binding
protein
1
(ZBP1)
stabilizes
nucleates
complex
containing
cGAS,
RIPK1,
RIPK3
to
sustain
STAT1
phosphorylation
type
I
interferon
(IFN-I)
signaling.
Elevated
mtDNA,
ZBP1
expression,
IFN-I
signaling
are
observed
in
cardiomyocytes
after
exposure
Doxorubicin,
first-line
chemotherapeutic
agent
induces
frequent
cardiotoxicity
cancer
patients.
Strikingly,
mice
lacking
or
protected
from
Doxorubicin-induced
cardiotoxicity.
Our
findings
reveal
as
cooperative
partner
for
cGAS
sustains
responses
highlight
potential
target
heart
failure
other
disorders
where
stress
contributes
interferon-related
pathology.
