Phytomedicine, Год журнала: 2025, Номер 137, С. 156377 - 156377
Опубликована: Янв. 6, 2025
Язык: Английский
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189175 - 189175
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
19
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117550 - 117550
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
17
Phytotherapy Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 4, 2025
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.
Язык: Английский
Процитировано
3
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Aggregation profoundly influences the photophysical properties of molecules. Here, a new series thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, star molecule HTPA exhibits remarkable pH-responsive behavior and significant increase in photoacoustic (PA) intensity when aggregated. Additionally, pH reversibility during formation are systematically investigated, including computational optimization, femtosecond transient absorption spectroscopy, NMR analysis, single crystal analysis. Finally, an innovative "off " nanoparticle specifically designed for effective tumor-targeted PA/NIR-II dual-modal imaging photodynamic therapy utilizing polymer. The signal-to-background ratio (SBR) PA signals significantly increased to 169 region interest (ROI) mouse model irradiated at 1064 nm. These findings not only provide promising avenue future studies NIR-II small molecules but also pave way advances field integrated cancer diagnosis therapy.
Язык: Английский
Процитировано
2
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер 20(2), С. 101018 - 101018
Опубликована: Янв. 10, 2025
Nitric oxide (NO) modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment integrated platforms combination or synergistic therapies. Although a nanoengineering strategy been proposed to overcome deficiencies NO gas small donor molecules, such as short half-life, lipophilicity, non-selectivity, poor stability, it remains challenging prepare nanomedicines with simple composition, multiple functions enhanced therapeutic efficacy. Herein, we build liquid metal nanodroplet (LMND)-based nanogenerator (LMND@HSG) that is stabilized by bioreducible guanylated hyperbranched poly(amido amine) (HSG) ligand. Mechanically, tumor microenvironment specifically triggers cascade process glutathione elimination, reactive oxygen species (ROS) generation, release. According actual demand, ROS concentrations could be readily controlled tuning LMND HSG feed amounts. Along intrinsic anticancer property (ROS-mediated apoptosis anti-angiogenesis), LMND@HSG administration further enhance growth suppression compared alone. From this study, leveraging therapy provides more possibilities prospect LMND-based nanomedicines.
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 12, 2025
Abstract Uveal melanoma (UM) is a highly aggressive ocular malignancy associated with poor prognosis and significant resistance to conventional therapies, including surgical resection, chemotherapy, radiotherapy, which are often limited by their efficacy adverse side effects. Energy‐conversion‐based nanodynamic therapy, facilitates the generation of reactive oxygen species (ROS), has emerged as promising approach for cancer treatment. Here, development high‐performance multifunctional thermoelectric nanocatalysts, specifically Cu 5 FeS 3.6 Se 0.4 nanoparticles, optimized effective synergistic treatment UM reported. These nanoparticles exhibit remarkable photothermal, thermoelectric, chemodynamic properties that enhance therapeutic efficacy. Under near‐infrared light irradiation, generate localized hyperthermia, not only induces direct tumor cell ablation but also produces potentials facilitate ROS generation. Additionally, hyperthermia induced photothermal effects these accelerates Fenton‐like reaction, leading formation hydroxyl radicals therapy. The resultant induce oxidative stress within cells, promoting mechanisms such cuproptosis pyroptosis. integration effects, potentials, therapy single nanoplatform represents an efficient strategy treatment, addressing shortcomings traditional therapies offering means managing this cancer.
Язык: Английский
Процитировано
1
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159738 - 159738
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 20, 2025
At present, the relationship between intake of antioxidants in food and mortality rate patients with chronic kidney disease (CKD), especially association specific causes, is not clear. This study included 6379 adult CKD from National Health Nutrition Examination Survey (2001–2018). Use Cox proportional hazards model, restricted cubic spline (RCS) stratified sensitivity analysis to evaluate Composite Dietary Antioxidant Index (CDAI) disease. During follow-up period, 2381 all-cause deaths were recorded, including 719 cardiovascular disease, 132 cerebrovascular 430 cancer. We found that compared lowest quartile CDAI, weighted multivariate hazard ratio participants highest was 0.83 (95% confidence interval: 0.72, 0.96) for mortality, Cardiovascular 0.91 0.70, 1.18), Cerebrovascular death 0.51 0.24, 1.07), Death due cancer 0.64 0.45, 0.92). RCS shows a non-linear CDAI mortality. same time, there no Stratified race BMI are influencing factors CDAI-CKD Sensitivity confirmed robustness results. Our research findings emphasize potential advantages an antioxidant diet reducing risk patients.
Язык: Английский
Процитировано
1
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 24, 2025
Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.
Язык: Английский
Процитировано
1