Molecules,
Год журнала:
2022,
Номер
27(5), С. 1680 - 1680
Опубликована: Март 3, 2022
5-Hydroxytryptamine
(5-HT,
serotonin)
is
a
neurotransmitter
in
both
the
central
nervous
system
and
peripheral
structures,
acting
also
as
hormone
platelets.
Although
its
concentration
gut
covers
>90%
of
all
organism
resources,
serotonin
mainly
known
that
takes
part
pathology
mental
diseases.
Serotonin
modulates
not
only
CNS
neurons,
but
pain
transmission
platelet
aggregation.
In
periphery,
5-HT
influences
muscle
motility
gut,
bronchi,
uterus,
vessels
directly
through
neurons.
synthesis
starts
from
hydroxylation
orally
delivered
tryptophan,
followed
by
decarboxylation.
acts
via
numerous
types
receptors
clinically
plays
role
several
neural,
mental,
other
chronic
disorders,
such
migraine,
carcinoid
syndrome,
some
dysfunctions
alimentary
system.
paracrine
growth
factor.
brain
are
targets
for
drugs
modifying
neurotransmission.
The
aim
present
article
to
review
gastrointestinal
(GI)
tract
determine
GI
physiology
pathology,
including
diseases
pharmacotherapy.
International Journal of Medical Microbiology,
Год журнала:
2021,
Номер
311(3), С. 151490 - 151490
Опубликована: Фев. 25, 2021
It
is
becoming
increasingly
clear
that
fungi
are
important
components
of
the
gut
microbiota.
Fungi
residing
in
human
intestine,
for
example,
elicit
induction
T
helper
17
cells,
which
central
orchestrators
protective
immune
responses.
Likewise,
fungal
members
intestinal
microbiota
have
been
shown
to
influence
immunological
responses
mammalian
host
by
dampening
or
promoting
local
inflammatory
Here
I
review
some
latest
developments
regarding
symbiotic
gastrointestinal
tract
and
consequences
dysbiosis
may
on
health.
A
major
focus
relationship
between
Candida
albicans,
most
prominent
fungus
inhabiting
gut,
host.
Advances
field
underscore
need
further
investigate
inhabit
body
understand
how
mixed
array
microbes
constitute
our
contribute
health
disease.
Abstract
Bacteria,
viruses,
protozoa,
and
fungi
establish
a
complex
ecosystem
in
the
gut.
Like
other
microbiota,
gut
mycobiota
plays
an
indispensable
role
modulating
intestinal
physiology.
Notably,
most
striking
characteristics
of
are
their
extraintestinal
functions.
Here,
we
provide
comprehensive
review
importance
regulation
intestinal,
pulmonary,
hepatic,
renal,
pancreatic,
brain
functions,
present
possible
opportunities
for
application
to
alleviate/treat
human
diseases.
Gut,
Год журнала:
2022,
Номер
71(9), С. 1812 - 1820
Опубликована: Янв. 11, 2022
Objective
The
human
gut
fungal
community,
known
as
the
mycobiome,
plays
a
fundamental
role
in
ecosystem
and
health.
Here
we
aimed
to
investigate
determinants
long-term
stability
of
mycobiome
among
middle-aged
elderly
adults.
We
further
explored
interplay
between
fungi
bacteria
on
metabolic
Design
present
study
included
1244
participants
from
Guangzhou
Nutrition
Health
Study.
characterised
especially
habitual
dietary
consumption.
comprehensive
multiomics
analyses
were
performed
ecological
links
bacteria,
faecal
metabolome.
Finally,
examined
whether
interaction
could
modulate
risk.
Results
composition
was
temporally
stable
mainly
determined
by
age,
diet
host
physiological
states.
Specifically,
compared
with
individuals,
Blastobotrys
Agaricomycetes
spp
depleted,
while
Malassezia
enriched
elderly.
Dairy
consumption
positively
associated
Saccharomyces
but
inversely
Candida
.
Notably,
Saccharomycetales
interacted
bacterial
diversity
influence
insulin
resistance.
Bidirectional
mediation
indicated
that
function
or
histidine
might
causally
mediate
an
impact
Pichia
blood
cholesterol.
Conclusion
depict
sociodemographic
reveal
may
be
closely
health
through
regulating
functions
metabolites.
Molecules,
Год журнала:
2022,
Номер
27(5), С. 1680 - 1680
Опубликована: Март 3, 2022
5-Hydroxytryptamine
(5-HT,
serotonin)
is
a
neurotransmitter
in
both
the
central
nervous
system
and
peripheral
structures,
acting
also
as
hormone
platelets.
Although
its
concentration
gut
covers
>90%
of
all
organism
resources,
serotonin
mainly
known
that
takes
part
pathology
mental
diseases.
Serotonin
modulates
not
only
CNS
neurons,
but
pain
transmission
platelet
aggregation.
In
periphery,
5-HT
influences
muscle
motility
gut,
bronchi,
uterus,
vessels
directly
through
neurons.
synthesis
starts
from
hydroxylation
orally
delivered
tryptophan,
followed
by
decarboxylation.
acts
via
numerous
types
receptors
clinically
plays
role
several
neural,
mental,
other
chronic
disorders,
such
migraine,
carcinoid
syndrome,
some
dysfunctions
alimentary
system.
paracrine
growth
factor.
brain
are
targets
for
drugs
modifying
neurotransmission.
The
aim
present
article
to
review
gastrointestinal
(GI)
tract
determine
GI
physiology
pathology,
including
diseases
pharmacotherapy.
