Genes,
Год журнала:
2023,
Номер
14(6), С. 1281 - 1281
Опубликована: Июнь 16, 2023
The
present
day's
ongoing
global
warming
and
climate
change
adversely
affect
plants
through
imposing
environmental
(abiotic)
stresses
disease
pressure.
major
abiotic
factors
such
as
drought,
heat,
cold,
salinity,
etc.,
hamper
a
plant's
innate
growth
development,
resulting
in
reduced
yield
quality,
with
the
possibility
of
undesired
traits.
In
21st
century,
advent
high-throughput
sequencing
tools,
state-of-the-art
biotechnological
techniques
bioinformatic
analyzing
pipelines
led
to
easy
characterization
plant
traits
for
stress
response
tolerance
mechanisms
by
applying
'omics'
toolbox.
Panomics
pipeline
including
genomics,
transcriptomics,
proteomics,
metabolomics,
epigenomics,
proteogenomics,
interactomics,
ionomics,
phenomics,
have
become
very
handy
nowadays.
This
is
important
produce
climate-smart
future
crops
proper
understanding
molecular
responses
genes,
transcripts,
proteins,
epigenome,
cellular
metabolic
circuits
resultant
phenotype.
Instead
mono-omics,
two
or
more
(hence
'multi-omics')
integrated-omics
approaches
can
decipher
well.
Multi-omics-characterized
be
used
potent
genetic
resources
incorporate
into
breeding
program.
For
practical
utility
crop
improvement,
multi-omics
particular
combined
genome-assisted
(GAB)
being
pyramided
improved
yield,
food
quality
associated
agronomic
open
new
era
omics-assisted
breeding.
Thus,
together
are
able
processes,
biomarkers,
targets
engineering,
regulatory
networks
precision
agriculture
solutions
crop's
variable
ensure
security
under
changing
circumstances.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Апрель 14, 2023
Abstract
Although
more
studies
are
demonstrating
that
a
father’s
environment
can
influence
child
health
and
disease,
the
molecular
mechanisms
underlying
non-genetic
inheritance
remain
unclear.
It
was
previously
thought
sperm
exclusively
contributed
its
genome
to
egg.
More
recently,
association
have
shown
various
environmental
exposures
including
poor
diet,
toxicants,
stress,
perturbed
epigenetic
marks
in
at
important
reproductive
developmental
loci
were
associated
with
offspring
phenotypes.
The
cellular
routes
underlie
how
transmitted
fertilization,
resist
reprogramming
embryo,
drive
phenotypic
changes
only
now
beginning
be
unraveled.
Here,
we
provide
an
overview
of
state
field
intergenerational
paternal
mammals
present
new
insights
into
relationship
between
embryo
development
three
pillars
inheritance:
chromatin,
DNA
methylation,
non-coding
RNAs.
We
evaluate
compelling
evidence
sperm-mediated
transmission
retention
embryo.
Using
landmark
examples,
discuss
sperm-inherited
regions
may
escape
impact
via
implicate
transcription
factors,
chromatin
organization,
transposable
elements.
Finally,
link
paternally
functional
pre-
post-implantation
Understanding
factors
will
permit
greater
understanding
related
origins
disease.
Trends in Microbiology,
Год журнала:
2024,
Номер
32(12), С. 1229 - 1240
Опубликована: Июнь 5, 2024
Recent
studies
of
dynamic
interactions
between
epigenetic
modifications
a
host
organism
and
the
composition
or
activity
its
associated
gut
microbiota
suggest
an
opportunity
for
to
shape
microbiome
through
alterations
that
lead
changes
in
gene
expression
noncoding
RNA
activity.
We
use
insights
from
microbiota-induced
review
potential
epigenetically
regulate
microbiome,
which
bidirectional
'epigenome–microbiome
axis'
emerges.
This
axis
embeds
environmentally
induced
variation,
may
influence
adaptive
evolution
host–microbe
interactions.
furthermore
present
our
perspective
on
how
epigenome–microbiome
can
be
understood
investigated
within
holo-omic
framework
with
applications
applied
health
food
sciences.
Redox Biology,
Год журнала:
2023,
Номер
62, С. 102695 - 102695
Опубликована: Апрель 5, 2023
Nutrigenomics
attempts
to
characterize
and
integrate
the
relation
between
dietary
molecules
gene
expression
on
a
genome-wide
level.
One
of
biologically
active
nutritional
compounds
is
vitamin
D3,
which
activates
via
its
metabolite
1α,25-dihydroxyvitamin
D3
(1,25(OH)2D3)
nuclear
receptor
VDR
(vitamin
D
receptor).
Vitamin
can
be
synthesized
endogenously
in
our
skin,
but
since
we
spend
long
times
indoors
often
live
at
higher
latitudes
where
for
many
winter
months
UV-B
radiation
too
low,
it
became
true
vitamin.
The
ligand-inducible
transcription
factor
expressed
majority
human
tissues
cell
types,
modulates
epigenome
thousands
genomic
sites.
In
tissue-specific
fashion
this
results
up-
downregulation
primary
target
genes,
some
are
involved
attenuating
oxidative
stress.
affects
wide
range
physiological
functions
including
control
metabolism,
bone
formation
immunity.
review,
will
discuss
how
epigenome-
transcriptome-wide
effects
1,25(OH)2D3
serve
as
master
example
nutrigenomics.
context,
outline
basis
mechanistic
understanding
personalized
nutrition
with
D3.
Genes,
Год журнала:
2023,
Номер
14(1), С. 120 - 120
Опубликована: Янв. 1, 2023
In
recent
years,
we
have
seen
an
increasing
amount
of
evidence
pointing
to
the
existence
a
non-genetic
heredity
effects
events
such
as
separation
from
parents,
threat
life,
or
other
traumatising
experiences
famine.
This
is
often
mediated
by
epigenetic
regulations
gene
expression
and
may
be
transferred
even
across
several
generations.
this
review,
focus
on
studies
which
involve
transgenerational
inheritance
(TEI),
with
short
detour
intergenerational
focused
trauma
stressful
experiences.
The
reviewed
show
plethora
universal
changes
stress
exposure
initiates
multiple
levels
organisation
ranging
hormonal
production
hypothalamic-pituitary-adrenal
(HPA)
axis
modulation
all
way
cognition,
behaviour,
propensity
certain
psychiatric
metabolic
disorders.
review
will
also
provide
overview
relevant
methodology
difficulties
linked
implementation
studies.
A
better
understanding
these
processes
help
us
elucidate
evolutionary
pathways
are
at
work
in
course
emergence
diseases
disorders
associated
trauma,
either
direct
previous
generation.
