Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 17, 2023
Dendritic
cells
(DCs),
central
participants
in
the
allergic
immune
response,
can
capture
and
present
allergens
leading
to
inflammation
immunopathogenesis
of
rhinitis
(AR).
In
addition
initiating
antigen-specific
responses,
DCs
induce
tolerance
modulate
homeostasis.
As
a
special
type
DCs,
tolerogenic
(tolDCs)
achieve
mainly
by
suppressing
effector
T
cell
responses
inducing
regulatory
(Tregs).
TolDCs
suppress
modulating
tolerance,
thereby
reducing
symptoms
AR.
Activation
TLR4/IRAK4/NF-κB
signaling
pathway
contributes
release
inflammatory
cytokines,
inhibitors
this
production
tolDCs
alleviate
responses.
This
review
focuses
on
relationship
between
with
Allergy,
Год журнала:
2024,
Номер
79(5), С. 1230 - 1241
Опубликована: Фев. 25, 2024
Identifying
predictive
biomarkers
for
allergen
immunotherapy
response
is
crucial
enhancing
clinical
efficacy.
This
study
aims
to
identify
such
in
patients
with
allergic
rhinitis
(AR)
undergoing
subcutaneous
(SCIT)
house
dust
mite
allergy.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 4, 2024
In
recent
years,
the
relationship
between
vitamin
D
and
allergic
diseases
has
received
widespread
attention.
As
a
fat-soluble
vitamin,
plays
crucial
role
in
regulating
immune
system
may
influence
onset
progression
of
such
as
atopic
dermatitis,
rhinitis,
asthma.
To
understand
underlying
mechanisms,
we
have
summarized
current
research
on
association
diseases.
We
also
discuss
impact
its
course
diseases,
particularly
focusing
how
supplementation
affects
treatment
outcomes
these
conditions.
aim
to
provide
theoretical
basis
practical
guidance
for
optimizing
management
by
modulating
levels.
Autoimmunity Reviews,
Год журнала:
2025,
Номер
24(5), С. 103775 - 103775
Опубликована: Фев. 13, 2025
Rheumatoid
Arthritis
(RA)
is
a
persistent
autoimmune
inflammatory
disorder
that
arises
from
the
intricate
interaction
between
genetic
predisposition
and
environmental
influences.
The
progression
of
RA
can
be
delineated
into
four
distinct
phases:
initially,
influence
risk
factors;
followed
by
emergence
systemic
autoimmunity;
subsequently,
an
asymptomatic
phase;
ultimately,
manifestation
clinical
arthritis.
Recently,
role
mucosal
immunity
in
has
gained
significant
attention
research.
Evidence
published
studies
suggests
not
only
influences
onset
but
also
plays
crucial
its
progression.
Scholars
have
begun
to
unravel
links
barriers
gastrointestinal
tract,
respiratory
system,
oral
cavity.
Specifically,
shifts
microbiota,
dysfunction
barriers,
abnormal
activation
immune
tissues
are
all
implicated
pathogenesis
RA.Despite
this
growing
body
knowledge,
comprehensive
review
therapeutic
implications
yet
conducted.
This
emphasizes
driving
abnormalities
development
autoimmunity
rheumatoid
arthritis
(RA).
It
further
explores
potential
RA,
as
well
issues
challenges
need
addressed
current
research
field,
providing
new
perspective
targets
for
prevention
treatment
RA.
Respiratory Medicine,
Год журнала:
2023,
Номер
210, С. 107125 - 107125
Опубликована: Янв. 23, 2023
Allergen
specific
immunotherapy
(AIT)
is
the
only
causal
therapeutic
option
for
allergic
airway
diseases
including
asthma
and
rhinitis.
AIT
has
been
shown
to
restore
allergen
immune
tolerance,
can
modify
both
early
late-onset
allergen-specific
hyperreactivity,
helps
achieve
disease
control/remission
prevents
new
sensitisations.
Recent
real
life
data
on
long-term
effectiveness
of
house
dust
mite
(HDM)
in
a
large
group
patients
with
HDM-driven
further
underscored
its
unique
potential
as
well
confirmed
previous
pollen
AIT.
More
widespread
use
this
treatment
select
patient
populations
should
move
promising
field.
In
mini-review,
we
discuss
updates
insights
based
world
data.
International Archives of Allergy and Immunology,
Год журнала:
2024,
Номер
185(5), С. 503 - 518
Опубликована: Янв. 1, 2024
Allergy
represents
a
major
health
problem
of
increasing
prevalence
worldwide
with
high
socioeconomic
impact.
Our
knowledge
on
the
molecular
mechanisms
underlying
allergic
diseases
and
their
treatments
has
significantly
improved
over
last
years.
The
generation
allergen-specific
regulatory
T
cells
(Tregs)
is
crucial
in
induction
healthy
immune
responses
to
allergens,
preventing
development
worsening
diseases.
Allergologie select,
Год журнала:
2024,
Номер
8(01), С. 6 - 11
Опубликована: Янв. 1, 2024
Remission
is
the
goal
of
modern
asthma
treatment.
Allergen
immunotherapy
(AIT)
an
essential
component
in
armamentarium
personalized
therapy.
Subcutaneous
AIT
(SCIT)
or
sublingual
(SLIT)
offer
possibility
to
prevent
patients
with
allergic
rhinitis
(reduction
risk
developing
asthma)
and
achieve
remission
asthma.
Accordingly,
should
always
be
considered
a
documented,
clinically
relevant
allergy.
However,
precise
phenotyping
patient
prerequisite
for
success
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 2, 2024
Introduction
Group
2
innate
lymphoid
cells
(ILC2s)
play
a
crucial
role
in
house
dust
mite
(HDM)-induced
allergic
inflammation,
and
allergen
immunotherapy
(AIT)
holds
promise
for
treating
the
disease
by
reducing
frequency
of
ILC2s.
Despite
significant
progress
AIT
diseases,
there
remains
need
to
improve
control
symptoms.
Methods
We
investigated
synergistic
effect
Notch
signaling
pathway
subcutaneous
(SCIT)
airway
inflammation
mice
their
impact
on
ratio
ILC2s
lung
tissues.
This
was
achieved
establishing
HDM-induced
disorders
(HAAD)
model
SCIT
model.
Additionally,
we
conducted
vitro
investigations
into
secretory
function
activated
using
fluorescence-activated
cell
sorting.
Furthermore,
explored
coactivation
with
sorting
from
tissues
after
modeling.
Results
Previously,
our
group
demonstrated
that
inhibitors
can
reduce
mice.
induces
lineage
plasticity
mature
In
this
study,
showed
alleviates
suppresses
induced
HDM.
Interestingly,
combined
γ-secretase
inhibitor
(GSI),
an
pathway,
significantly
inhibited
ILC2s,
reduced
suppressed
Th2-type
responses
mouse
HDM-challenged
or
without
were
treated
GSI
,
found
dramatically
secretion
type
inflammatory
factors
Discussion
These
findings
suggest
be
used
as
adjuvant
therapy
may
hold
potential
treatment
value
cooperative
during
early
AIT.
