Journal of Experimental & Clinical Cancer Research,
Год журнала:
2022,
Номер
41(1)
Опубликована: Фев. 19, 2022
Abstract
Cancer
immunotherapy
has
emerged
as
a
novel
cancer
treatment,
although
recent
trials
have
produced
suboptimal
outcomes,
with
durable
responses
seen
only
in
small
number
of
patients.
The
tumor
microenvironment
(TME)
been
shown
to
be
responsible
for
immune
escape
and
therapy
failure.
vital
component
the
TME
is
tumor-associated
macrophages
(TAMs),
which
are
usually
associated
poor
prognosis
drug
resistance,
including
immunotherapies,
promising
targets
immunotherapy.
Recently,
nanoparticles,
because
their
unique
physicochemical
characteristics,
crucial
translational
moieties
tackling
tumor-promoting
TAMs
that
amplify
sensitize
tumors
immunotherapies
safe
effective
manner.
In
this
review,
we
mainly
described
current
potential
nanomaterial-based
therapeutic
strategies
target
TAMs,
restricting
survival,
inhibiting
recruitment
functionally
repolarizing
tumor-supportive
antitumor
type.
understanding
origin
polarization
role
progression
prognostic
significance
was
also
discussed
review.
We
highlighted
evolution
chimeric
antigen
receptor
(CAR)-macrophage
cell
therapy.
Metal-organic
frameworks
(MOFs)
are
an
interesting
and
useful
class
of
coordination
polymers,
constructed
from
metal
ion/cluster
nodes
functional
organic
ligands
through
bonds,
have
attracted
extensive
research
interest
during
the
past
decades.
Due
to
unique
features
diverse
compositions,
facile
synthesis,
easy
surface
functionalization,
high
areas,
adjustable
porosity,
tunable
biocompatibility,
MOFs
been
widely
used
in
hydrogen/methane
storage,
catalysis,
biological
imaging
sensing,
drug
delivery,
desalination,
gas
separation,
magnetic
electronic
devices,
nonlinear
optics,
water
vapor
capture,
etc.
Notably,
with
rapid
development
synthetic
methods
functionalization
strategies,
smart
MOF-based
nanocomposites
advanced
bio-related
properties
designed
fabricated
meet
growing
demands
MOF
materials
for
biomedical
applications.
This
work
outlines
synthesis
recent
advances
fields,
including
cargo
(drugs,
nucleic
acids,
proteins,
dyes)
delivery
cancer
therapy,
bioimaging,
antimicrobial,
biosensing,
biocatalysis.
The
prospects
challenges
field
also
discussed.
Chemical Society Reviews,
Год журнала:
2020,
Номер
50(2), С. 1111 - 1137
Опубликована: Ноя. 27, 2020
This
review
summarizes
the
recent
development
of
second
near-infrared
photothermal
combinational
nanotheranostics
for
cancer,
infectious
diseases
and
regenerative
medicine.
Frontiers in Chemistry,
Год журнала:
2021,
Номер
9
Опубликована: Июль 13, 2021
Diverse
applications
of
nanoparticles
(NPs)
have
revolutionized
various
sectors
in
society.
In
the
recent
decade,
particularly
magnetic
(MNPs)
gained
enormous
interest
owing
to
their
specialized
areas
such
as
medicine,
cancer
theranostics,
biosensing,
catalysis,
agriculture,
and
environment.
Controlled
surface
engineering
for
design
multi-functional
MNPs
is
vital
achieving
desired
application.
The
demonstrated
great
efficacy
thermoelectric
materials,
imaging
agents,
drug
delivery
vehicles,
biosensors.
present
review,
first
we
briefly
discussed
main
synthetic
methods
MNPs,
followed
by
characterizations
composition.
Then
potential
different
with
representative
examples.
At
end,
gave
an
overview
on
current
challenges
future
prospects
MNPs.
This
comprehensive
review
not
only
provides
mechanistic
insight
into
synthesis,
functionalization,
application
but
also
outlines
limits
prospects.
Advanced Materials,
Год журнала:
2020,
Номер
32(47)
Опубликована: Окт. 16, 2020
Ultrasound
(US)-triggered
sonodynamic
therapy
(SDT),
as
a
promising
noninvasive
therapeutic
modality,
has
received
ever-increasing
attention
in
recent
years.
Its
specialized
chemical
agents,
named
sonosensitizers,
are
activated
by
low-intensity
US
to
produce
lethal
reactive
oxygen
species
(ROS)
for
oncotherapy.
Compared
with
phototherapeutic
strategies,
SDT
provides
many
noteworthy
opportunities
and
benefits,
such
deeper
penetration
depth,
absence
of
phototoxicity,
fewer
side
effects.
Nevertheless,
previous
studies
have
also
demonstrated
its
intrinsic
limitations.
Thanks
the
facile
engineering
nature
nanotechnology,
numerous
novel
nanoplatforms
being
applied
this
emerging
field
tackle
these
barriers
achieve
continuous
innovations.
In
particular,
combination
other
treatment
strategies
superior
efficacy
improving
anticancer
activity
relative
that
monotherapies
alone.
Therefore,
it
is
necessary
summarize
nanomaterial-assisted
combinational
cancer
applications.
Herein,
design
principles
achieving
synergistic
effects
based
on
nanomaterial
methods
highlighted.
The
ultimate
goals
stimulate
better-quality
combined
schemes
provide
innovative
ideas
perspectives
promoting
future
transformation
clinical
application.
Abstract
Tumor
immunotherapy
is
only
effective
in
a
fraction
of
patients
due
to
low
response
rate
and
severe
side
effects,
these
challenges
clinics
can
be
addressed
through
induction
immunogenic
cell
death
(ICD).
ICD
elicited
from
many
antitumor
therapies
release
danger
associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
facilitate
maturation
dendritic
cells
(DCs)
infiltration
cytotoxic
T
lymphocytes
(CTLs).
The
process
reverse
the
tumor
immunosuppressive
microenvironment
improve
sensitivity
immunotherapy.
Nanostructure‐based
drug
delivery
systems
(NDDSs)
are
explored
induce
by
incorporating
therapeutic
molecules
for
chemotherapy,
photosensitizers
(PSs)
photodynamic
therapy
(PDT),
photothermal
conversion
agents
(PTT),
radiosensitizers
radiotherapy
(RT).
These
NDDSs
loaded
at
right
dose
place
time,
resulting
greater
effectiveness
lower
toxicity.
Immunotherapeutic
also
combined
with
achieve
synergic
effect
multi‐modality
approach.
In
this
review,
harnessed
load
multiple
PDT,
PTT,
RT
combination
promote
reduce
effects
cancer
treatment.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Фев. 2, 2021
Abstract
Nanomedicine
in
combination
with
immunotherapy
offers
opportunities
to
treat
cancer
a
safe
and
effective
manner;
however,
remote
control
of
immune
response
spatiotemporal
precision
remains
challenging.
We
herein
report
photothermally
activatable
polymeric
pro-nanoagonist
(APNA)
that
is
specifically
regulated
by
deep-tissue-penetrating
second
near-infrared
(NIR-II)
light
for
combinational
photothermal
immunotherapy.
APNA
constructed
from
covalent
conjugation
an
immunostimulant
onto
NIR-II
semiconducting
transducer
through
labile
thermo-responsive
linker.
Upon
photoirradiation,
mediates
effect,
which
not
only
triggers
tumor
ablation
immunogenic
cell
death
but
also
initiates
the
cleavage
thermolabile
linker
liberate
caged
agonist
in-situ
activation
deep
solid
(8
mm).
Such
controlled
regulation
potentiates
systemic
antitumor
immunity,
leading
promoted
cytotoxic
T
lymphocytes
helper
infiltration
distal
tumor,
lung
liver
inhibit
metastasis.
Thereby,
present
work
illustrates
generic
strategy
prepare
pro-immunostimulants
nano-immunotherapy.
