Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 25, 2023

Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.

Язык: Английский

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Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Год журнала: 2021, Номер 50(15), С. 8762 - 8789

Опубликована: Янв. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Язык: Английский

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Rough Carbon–Iron Oxide Nanohybrids for Near-Infrared-II Light-Responsive Synergistic Antibacterial Therapy

ACS Nano, Год журнала: 2021, Номер 15(4), С. 7482 - 7490

Опубликована: Апрель 15, 2021

Infections caused by multidrug resistant bacteria are still a serious threat to human health. It is of great significance explore effective alternative antibacterial strategies. Herein, carbon–iron oxide nanohybrids with rough surfaces (RCF) developed for NIR-II light-responsive synergistic therapy. RCF excellent photothermal property and peroxidase-like activity could realize therapy (PTT)/chemodynamic (CDT) in the biowindow improved penetration depth low power density. More importantly, shows increased bacterial adhesion, thereby benefiting both CDT PTT through interaction between bacteria. In vitro experiments demonstrate broad-spectrum effect against Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus), methicillin-resistant (MRSA). addition, satisfactory biocompatibility makes promising agent. Notably, performances vivo be achieved employing rat wound model MRSA infection. The current study proposes facile strategy construct agents practical applications rational design composition morphology. density light responsive holds potential treatment drug-resistant infections.

Язык: Английский

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Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 4996 - 5041

Опубликована: Янв. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Язык: Английский

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Layered double hydroxide-based nanomaterials for biomedical applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(14), С. 6126 - 6176

Опубликована: Янв. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Язык: Английский

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Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Год журнала: 2022, Номер 2(6)

Опубликована: Май 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Язык: Английский

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Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(15), С. 6307 - 6416

Опубликована: Янв. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Язык: Английский

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NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

Advanced Functional Materials, Год журнала: 2021, Номер 31(32)

Опубликована: Июнь 10, 2021

Abstract Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed deeper‐seated tumor treatment in recent years compared the first light (750–1000 nm). In addition, use of emerging inorganic 2D nanomaterials as agents (PTAs) further enhanced efficiency due to their intrinsic properties. NIR‐II stimulated becoming hot topic both academic and clinical fields. This review summarizes categories, structures, conversion properties time. synergistic strategies responsive combined other approaches including chemotherapy, chemodynamic therapy, photodynamic radiotherapy are summarized. future challenges perspectives on these systems construction discussed.

Язык: Английский

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Stimuli‐Responsive Deep‐Blue Organic Ultralong Phosphorescence with Lifetime over 5 s for Reversible Water‐Jet Anti‐Counterfeiting Printing

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(31), С. 17094 - 17101

Опубликована: Май 18, 2021

Abstract Organic ultralong room temperature phosphorescence (OURTP) materials with photophysical properties sensitive to external stimulus are highly attractive for advanced applications. However, most OURTP molecules in crystal and good practicability stimulus‐responsive character hard be achieved. Here, we report, the first time, efficient, ultralong‐lived deep‐blue by simply doping boron phosphor into cyanuric acid host. Host–guest composites abundant tunable H‐bond network stable air lifetime of 5.08 s at temperature. They water, which can strength significantly enhance quantum yield from 16.1 % 37.6 %. Anti‐counterfeiting paper was easily prepared water‐jet printing; jet‐printed high‐resolution patterns erased solvent fuming another printing/erasing cycle high reversibility.

Язык: Английский

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