Biomacromolecules,
Год журнала:
2024,
Номер
25(2), С. 541 - 563
Опубликована: Янв. 19, 2024
Nanoformulation
of
active
payloads
or
pharmaceutical
ingredients
(APIs)
has
always
been
an
area
interest
to
achieve
targeted,
sustained,
and
efficacious
delivery.
Various
delivery
platforms
have
explored,
but
loading
APIs
challenging
because
the
chemical
structural
properties
these
molecules.
Polymersomes
made
from
amphiphilic
block
copolymers
(ABCPs)
shown
enormous
promise
as
a
tunable
API
platform
confer
multifold
advantages
over
lipid-based
systems.
For
example,
COVID
booster
vaccine
comprising
polymersomes
encapsulating
spike
protein
(ACM-001)
recently
completed
Phase
I
clinical
trial
provides
case
for
developing
safe
drug
products
based
on
ABCP
platforms.
However,
several
limitations
need
be
resolved
before
they
can
reach
their
full
potential.
In
this
Perspective,
we
would
like
highlight
such
aspects
requiring
further
development
translating
ABCP-based
proof
concept
viable
commercial
product.
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
Advanced Materials,
Год журнала:
2023,
Номер
35(51)
Опубликована: Май 17, 2023
Abstract
Messenger
RNA
(mRNA)
has
received
great
attention
in
the
prevention
and
treatment
of
various
diseases
due
to
success
coronavirus
disease
2019
(COVID‐19)
mRNA
vaccines
(Comirnaty
Spikevax).
To
meet
therapeutic
purpose,
it
is
required
that
must
enter
target
cells
express
sufficient
proteins.
Therefore,
development
effective
delivery
systems
necessary
crucial.
Lipid
nanoparticle
(LNP)
represents
a
remarkable
vehicle
indeed
accelerated
applications
humans,
as
several
mRNA‐based
therapies
have
already
been
approved
or
are
clinical
trials.
In
this
review,
focus
on
mRNA‐LNP‐mediated
anticancer
therapy.
It
summarizes
main
strategies
mRNA‐LNP
formulations,
discusses
representative
approaches
cancer,
points
out
current
challenges
possible
future
directions
research
field.
hoped
these
delivered
messages
can
help
further
improve
application
technology
cancer
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 976 - 976
Опубликована: Март 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(43)
Опубликована: Ноя. 21, 2023
Abstract
Metal–organic
framework
(MOF)
materials
are
gaining
significant
interest
in
biomedical
research,
owing
to
their
high
porosity,
crystallinity,
and
structural
compositional
diversity.
Their
versatile
hybrid
organic/inorganic
chemistry
endows
MOFs
with
the
capacity
retain
organic
(drug)
molecules,
metals,
gases,
effectively
channel
electrons
photons,
survive
harsh
physiological
conditions
such
as
low
pH,
even
protect
sensitive
biomolecules.
Extensive
preclinical
research
has
been
carried
out
treat
several
pathologies
and,
recently,
integration
other
stents
implants
demonstrated
promising
performance
regenerative
medicine.
However,
there
remains
a
gap
between
MOF
translation
into
clinically
societally
relevant
medicinal
products.
Here,
intrinsic
features
of
outlined
suitability
specific
applications
detoxification,
drug
gas
delivery,
or
(combination)
therapy
platforms
is
discussed.
Furthermore,
examples
how
have
engineered
evaluated
different
medical
indications,
including
cancer,
microbial,
inflammatory
diseases
described.
Finally,
challenges
facing
clinic
critically
examined,
goal
establishing
directions
more
realistic
approaches
that
can
bridge
translational
MOF‐containing
(nano)materials.
