Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Microbiome, Год журнала: 2021, Номер 9(1)

Опубликована: Сен. 7, 2021

Abstract Background Alteration of the gut microbiota may contribute to development inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent green tea, is known be beneficial in IBD alleviation. However, it unclear whether exerts an effect when EGCG attenuates IBD. Results We first explored oral or rectal delivery on DSS-induced murine colitis. Our results revealed that anti-inflammatory and colonic barrier integrity were enhanced by oral, but not rectal, EGCG. observed distinct EGCG-mediated alteration microbiome increasing Akkermansia abundance butyrate production. Next, we demonstrated pre-supplementation induced similar outcomes administration. Prophylactic attenuated colitis significantly enriched short-chain fatty acids (SCFAs)-producing bacteria such as SCFAs production mice. To validate these discoveries, performed fecal transplantation (FMT) sterile filtrate (SFF) inoculate DSS-treated Microbiota from EGCG-dosed mice alleviated over control SFF shown superiorly integrity, also SCFAs. Collectively, attenuation suggests intimate involvement SCFAs-producing , SCFAs, which was further prophylaxis FMT. Conclusions This study provides data indicating ameliorated inflammation microbiota-dependent manner. findings provide novel insights into remission potential modulator for prevent treat

Язык: Английский

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Oral microbiota in human systematic diseases

International Journal of Oral Science, Год журнала: 2022, Номер 14(1)

Опубликована: Март 2, 2022

Abstract Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with host to reflect information immunity metabolism through two-way communication along cavity systemic organs. is one most important interaction windows between human body environment. microenvironment at different sites in has microbial compositions regulated by complex signaling, hosts, external environmental factors. These processes may or health because certain states seem be related composition bacteria, destruction community In this review, we discussed emerging exciting evidence connections microbes multiple diseases, possible contribution microorganisms This review aims enhance interest on whole body, also improve clinician’s understanding role Microbial research dentistry potentially enhances our knowledge pathogenic mechanisms same time, continuous advances frontier field lead a tangible impact health.

Язык: Английский

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Intestinal Barrier in Human Health and Disease

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(23), С. 12836 - 12836

Опубликована: Дек. 6, 2021

The intestinal mucosa provides a selective permeable barrier for nutrient absorption and protection from external factors. It consists of epithelial cells, immune cells their secretions. gut microbiota participates in regulating the integrity function homeostatic balance. Pathogens, xenobiotics food can disrupt barrier, promoting systemic inflammation tissue damage. Genetic factors predispose individuals to dysfunction, changes composition are central this process. progressive identification these has led development concept ‘leaky syndrome’ ‘gut dysbiosis’, which underlie relationship between impairment, metabolic diseases autoimmunity. Understanding mechanisms underlying process is an intriguing subject research diagnosis treatment various extraintestinal diseases.

Язык: Английский

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Gut microbiome, liver immunology, and liver diseases

Cellular and Molecular Immunology, Год журнала: 2020, Номер 18(1), С. 4 - 17

Опубликована: Дек. 14, 2020

Язык: Английский

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Gut barrier disruption and chronic disease

Trends in Endocrinology and Metabolism, Год журнала: 2022, Номер 33(4), С. 247 - 265

Опубликована: Фев. 9, 2022

Язык: Английский

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Pathogenesis of autoimmune disease

Nature Reviews Nephrology, Год журнала: 2023, Номер 19(8), С. 509 - 524

Опубликована: Май 10, 2023

Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell and T reactivity to normal constituents the host. These occur widely affect individuals all ages, especially women. Among these diseases, most prominent immunological manifestation is production autoantibodies, which provide valuable biomarkers for diagnosis, classification disease activity. Although cells have key role in pathogenesis, they technically more difficult assay. In general, autoimmune results from an interplay between genetic predisposition environmental factors. Genetic autoimmunity complex can involve multiple genes that regulate function immune populations. Less frequently, result single-gene mutations regulatory pathways. Infection seems be common trigger disease, although microbiota also influence pathogenesis. As shown seminal studies, patients may express autoantibodies many years before appearance clinical or laboratory signs — period called pre-clinical autoimmunity. Monitoring autoantibody expression at-risk populations therefore enable early detection initiation therapy prevent attenuate tissue damage. Autoimmunity not static, however, remission achieved some treated with current agents. host constituents. This Review provides overview basis focus on given their as markers

Язык: Английский

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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Allergy, Год журнала: 2022, Номер 77(5), С. 1418 - 1449

Опубликована: Фев. 2, 2022

Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.

Язык: Английский

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Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2022, Номер 20(5), С. 323 - 337

Опубликована: Окт. 21, 2022

Язык: Английский

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Leveraging diet to engineer the gut microbiome

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2021, Номер 18(12), С. 885 - 902

Опубликована: Сен. 27, 2021

Язык: Английский

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Within-host evolution of a gut pathobiont facilitates liver translocation

Nature, Год журнала: 2022, Номер 607(7919), С. 563 - 570

Опубликована: Июль 13, 2022

Язык: Английский

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