Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Май 5, 2023
A
growing
body
of
research
suggests
that
short-chain
fatty
acids
(SCFAs),
metabolites
produced
by
intestinal
symbiotic
bacteria
ferment
dietary
fibers
(DFs),
play
a
crucial
role
in
the
health
status
symbiotes.
SCFAs
act
on
variety
cell
types
to
regulate
important
biological
processes,
including
host
metabolism,
function,
and
immune
function.
also
affect
function
fate
cells.
This
finding
provides
new
concept
metabolism
better
understanding
regulatory
system,
which
impacts
prevention
treatment
disease.
The
mechanism
induce
or
response
is
becoming
increasingly
clear.
review
summarizes
different
mechanisms
through
According
latest
research,
innate
NLRP3
inflammasomes,
receptors
TLR
family
members,
neutrophils,
macrophages,
natural
killer
cells,
eosinophils,
basophils
lymphocyte
subsets,
emphasized.
adaptive
T-cell
B
plasma
highlighted.
In
addition,
we
discuss
regulating
allergic
airway
inflammation,
colitis,
osteoporosis
influencing
system.
These
findings
provide
evidence
for
determining
options
based
metabolic
regulation.
Molecular Neurodegeneration,
Год журнала:
2022,
Номер
17(1)
Опубликована: Июнь 17, 2022
A
consequence
of
our
progressively
ageing
global
population
is
the
increasing
prevalence
worldwide
age-related
cognitive
decline
and
dementia.
In
absence
effective
therapeutic
interventions,
identifying
risk
factors
associated
with
becomes
increasingly
vital.
Novel
perspectives
suggest
that
a
dynamic
bidirectional
communication
system
between
gut,
its
microbiome,
central
nervous
system,
commonly
referred
to
as
microbiota-gut-brain
axis,
may
be
contributing
factor
for
health
disease.
However,
exact
mechanisms
remain
undefined.
Microbial-derived
metabolites
produced
in
gut
can
cross
intestinal
epithelial
barrier,
enter
systemic
circulation
trigger
physiological
responses
both
directly
indirectly
affecting
functions.
Dysregulation
this
(i.e.,
dysbiosis)
modulate
cytotoxic
metabolite
production,
promote
neuroinflammation
negatively
impact
cognition.
review,
we
explore
critical
connections
microbial-derived
(secondary
bile
acids,
trimethylamine-N-oxide
(TMAO),
tryptophan
derivatives
others)
their
influence
upon
function
neurodegenerative
disorders,
particular
interest
less-explored
role
decline.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Май 5, 2023
A
growing
body
of
research
suggests
that
short-chain
fatty
acids
(SCFAs),
metabolites
produced
by
intestinal
symbiotic
bacteria
ferment
dietary
fibers
(DFs),
play
a
crucial
role
in
the
health
status
symbiotes.
SCFAs
act
on
variety
cell
types
to
regulate
important
biological
processes,
including
host
metabolism,
function,
and
immune
function.
also
affect
function
fate
cells.
This
finding
provides
new
concept
metabolism
better
understanding
regulatory
system,
which
impacts
prevention
treatment
disease.
The
mechanism
induce
or
response
is
becoming
increasingly
clear.
review
summarizes
different
mechanisms
through
According
latest
research,
innate
NLRP3
inflammasomes,
receptors
TLR
family
members,
neutrophils,
macrophages,
natural
killer
cells,
eosinophils,
basophils
lymphocyte
subsets,
emphasized.
adaptive
T-cell
B
plasma
highlighted.
In
addition,
we
discuss
regulating
allergic
airway
inflammation,
colitis,
osteoporosis
influencing
system.
These
findings
provide
evidence
for
determining
options
based
metabolic
regulation.
