Microbial extracellular polymeric substances in the environment, technology and medicine

Nature Reviews Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

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Oxidative stress responses in biofilms

Biofilm, Год журнала: 2024, Номер 7, С. 100203 - 100203

Опубликована: Май 23, 2024

Oxidizing agents are low-molecular-weight molecules that oxidize other substances by accepting electrons from them. They include reactive oxygen species (ROS), such as superoxide anions (O

Язык: Английский

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Microbial strategies driving low concentration substrate degradation for sustainable remediation solutions

npj Clean Water, Год журнала: 2024, Номер 7(1)

Опубликована: Июнь 25, 2024

Abstract Microbial metabolism upholds a fundamental role in the sustainability of water ecosystems. However, how microorganisms surviving low-concentration substrate environments, including existence emerging compounds interest, remains unclear. In this review, microbial strategies for concentrating, utilizing, and metabolizing low concentration substrates were summarized. Microorganisms develop substrate-concentrating at both cell aggregate levels substrate-limited settings. Following, uptake transport are facilitated by adjusting physiological characteristics shifting affinities. Finally, metabolic pathways, such as mixed-substrate utilization, syntrophic metabolism, dynamic response to nutrient variation, population density-based mechanisms allow efficiently utilize adapt challenging oligotrophic environments. All these will underpin devising new approaches tackle environmental challenges drive ecosystems, particularly managing contaminants (i.e., micropollutants).

Язык: Английский

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Uncovering the Molecular Composition and Architecture of the Bacillus subtilis Biofilm via Solid-State NMR Spectroscopy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(17), С. 11906 - 11923

Опубликована: Апрель 17, 2024

The complex and dynamic compositions of biofilms, along with their sophisticated structural assembly mechanisms, endow them exceptional capabilities to thrive in diverse conditions that are typically unfavorable for individual cells. Characterizing biofilms native state is significantly challenging due intrinsic complexities the limited availability noninvasive techniques. Here, we utilized solid-state nuclear magnetic resonance (NMR) spectroscopy analyze Bacillus subtilis in-depth. Our data uncover a dynamically distinct organization within biofilm: dominant, hydrophilic, mobile framework interspersed minor, rigid cores water accessibility. In these heterogeneous cores, major components largely self-assembled. TasA fibers, most robust elements, further provide degree mechanical support cell aggregates some lipid vesicles. Notably, can persist even without extracellular polymeric substance (EPS) polymers, although this leads slight variations rigidity Exopolysaccharides exclusively present domain, playing pivotal role its retention property. Specifically, all molecules tightly bound biofilm matrix. These findings reveal dual-layered defensive strategy diffusion barrier through mobility phase physical posed by accessibility phase. Complementing discoveries, our comprehensive, situ compositional analysis not only essential delineating architecture but also reveals presence alternative genetic mechanisms synthesizing exopolysaccharides beyond known pathway.

Язык: Английский

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Programmable Bacterial Biofilms as Engineered Living Materials

Accounts of Materials Research, Год журнала: 2024, Номер 5(7), С. 797 - 808

Опубликована: Июнь 15, 2024

ConspectusBiological substances like wood and bone demonstrate extraordinary characteristics of "living" features, such as the ability to self-grow, self-heal upon encountering damage, sense adapt environmental changes. These attributes are crucial for their survival adaptation in complex environments. In field material science, there is a growing interest developing biomimetic materials that can self-monitor, conditions, self-repair when necessary. Such capabilities would extend lifespan pave way intelligent applications. However, creating with autonomy intelligence on par biological systems remains daunting challenge. this context, synthetic biology offers promising avenue. It not only allows harnessing inherent dynamic properties living organisms but provides possibility imparting additional advanced functionalities beyond reach systems. This approach enables integration cells into materials, providing them naturally endowed or artificially designed traits. innovative known Engineered Living Materials (ELMs), represent an emerging category smart capable autonomous functions, applications varying from biomedicine sustainable technology.Microbial biofilms, owing self-organizing serve exemplary starting point ELMs. Biofilms consist communities microorganisms residing within three-dimensional (3D) extracellular matrices polymeric (EPS). offer ideal blueprint designing ELMs, attributing remarkable stability, enhanced resilience against severe genetic programmability EPS components. Various biofilm-based have been developed using biofilm components structural proteins, bacterial cellulose, fungal mycelium, ranging pollution remediation, building construction, clean energy generation, biomedicine. Drawing traits shared natural systems, those ELMs divided three main groups: environmentally responsive composite materials. Self-organizing created by genetically altering components, giving rise new functions while maintaining intrinsic hierarchical self-assembling features biofilms. Environmentally harboring gene circuits enable monitor external conditions respond particular cues. High-performance integrate modified biofilms nonliving artificial substances, unique benefits both account overview these categories highlighting respective design strategies significant By combining principles science biology, potential create adaptive properties. Account also addresses challenges prospects associated intending spark ideas foster interdisciplinary collaborations field.

Язык: Английский

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Beyond 25 years of biomedical innovation in nano-bioelectronics

Device, Год журнала: 2024, Номер 2(7), С. 100401 - 100401

Опубликована: Июль 1, 2024

Nano-bioelectronics, which blend the precision of nanotechnology with complexity biological systems, are evolving innovations such as silicon nanowires, carbon nanotubes, and graphene. These elements serve applications from biochemical sensing to brain-machine interfacing. This review examines nano-bioelectronics' role in advancing biomedical interventions discusses their potential environmental monitoring, agricultural productivity, energy efficiency, creative fields. The field is transitioning molecular ecosystem-level applications, research exploring complex cellular mechanisms communication. fosters understanding interactions at various levels, suggesting transformative approaches for ecosystem management food security. Future expected focus on refining nano-bioelectronic devices integration systems scalable manufacturing broaden reach functionality.

Язык: Английский

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The Battle Against Biofilms: A Focus on Novel Antimicrobial Strategies and Their Mechanisms of Action

Antibiotics, Год журнала: 2025, Номер 14(2), С. 111 - 111

Опубликована: Янв. 21, 2025

Biofilms represent the predominant mode of microbial growth across a variety environments, encompassing both natural and anthropogenic settings [...]

Язык: Английский

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Electrogenic Dynamics of Biofilm Formation: Correlation Between Genetic Expression and Electrochemical Activity in Bacillus subtilis

Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117218 - 117218

Опубликована: Янв. 1, 2025

Язык: Английский

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Release of extracellular DNA by Pseudomonas species as a major determinant for biofilm switching and an early indicator for cell population control

iScience, Год журнала: 2025, Номер 28(3), С. 112063 - 112063

Опубликована: Фев. 18, 2025

Язык: Английский

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Exploring the interaction between quorum sensing and sludge physical properties in Anammox systems

Bioresource Technology, Год журнала: 2025, Номер 424, С. 132224 - 132224

Опубликована: Фев. 21, 2025

Язык: Английский

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