Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Nature Genetics, Год журнала: 2019, Номер 51(12), С. 1664 - 1669

Опубликована: Ноя. 29, 2019

Язык: Английский

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Organization and regulation of gene transcription

Nature, Год журнала: 2019, Номер 573(7772), С. 45 - 54

Опубликована: Авг. 28, 2019

Язык: Английский

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Determinants of enhancer and promoter activities of regulatory elements

Nature Reviews Genetics, Год журнала: 2019, Номер 21(2), С. 71 - 87

Опубликована: Окт. 11, 2019

Язык: Английский

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Recent advancements in molecular marker-assisted selection and applications in plant breeding programmes

Journal of Genetic Engineering and Biotechnology, Год журнала: 2021, Номер 19(1), С. 128 - 128

Опубликована: Авг. 27, 2021

DNA markers improved the productivity and accuracy of classical plant breeding by means marker-assisted selection (MAS). The enormous number quantitative trait loci (QTLs) mapping read for different species have given a plenitude molecular marker-gene associations. In this review, we discussed positive aspects its precise applications in programmes. Molecular has considerably shortened time new crop varieties to be brought market. To explore information about markers, many reviews been published last few decades; all these were intended breeders obtain on genetics. synopsis recent developments their application programmes devoted early with little or no knowledge markers. progress made breeding, genetics, genomics selection, editing genome contributed comprehensive understanding provides several proofs genetic diversity available plants greatly complemented devices. MAS revolutionized process acceleration accuracy, which is continuously empowering around world.

Язык: Английский

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A joint NCBI and EMBL-EBI transcript set for clinical genomics and research

Nature, Год журнала: 2022, Номер 604(7905), С. 310 - 315

Опубликована: Апрель 6, 2022

Abstract Comprehensive genome annotation is essential to understand the impact of clinically relevant variants. However, absence a standard for clinical reporting and browser display complicates process consistent interpretation reporting. To address these challenges, Ensembl/GENCODE 1 RefSeq 2 launched joint initiative, Matched Annotation from NCBI EMBL-EBI (MANE) collaboration, converge on human gene transcript jointly define high-value set transcripts corresponding proteins. Here, we describe MANE sets use as universal standards variant display. The Select identifies representative each protein-coding gene, whereas Plus Clinical provides additional at loci where alone are not sufficient report all currently known Each represents an exact match between exonic sequences its counterpart in such that identifiers can be used synonymously. We have now released 97% genes, including American College Medical Genetics Genomics Secondary Findings list v3.0 (ref. 3 ) genes. accessible major browsers key resources. Widespread adoption will increase consistency reporting, facilitate exchange data regardless source help streamline interpretation.

Язык: Английский

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The molecular principles of gene regulation by Polycomb repressive complexes

Nature Reviews Molecular Cell Biology, Год журнала: 2021, Номер 22(12), С. 815 - 833

Опубликована: Авг. 16, 2021

Язык: Английский

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Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

Nature Cell Biology, Год журнала: 2019, Номер 21(10), С. 1286 - 1299

Опубликована: Сен. 30, 2019

Язык: Английский

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The DNA damage response to transcription stress

Nature Reviews Molecular Cell Biology, Год журнала: 2019, Номер 20(12), С. 766 - 784

Опубликована: Сен. 26, 2019

Язык: Английский

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Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

Science China Life Sciences, Год журнала: 2020, Номер 63(7), С. 953 - 985

Опубликована: Апрель 30, 2020

Язык: Английский

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The epigenetic basis of cellular heterogeneity

Nature Reviews Genetics, Год журнала: 2020, Номер 22(4), С. 235 - 250

Опубликована: Ноя. 26, 2020

Язык: Английский

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