Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Nature Genetics, Journal Year: 2019, Volume and Issue: 51(12), P. 1664 - 1669

Published: Nov. 29, 2019

Language: Английский

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Organization and regulation of gene transcription

Nature, Journal Year: 2019, Volume and Issue: 573(7772), P. 45 - 54

Published: Aug. 28, 2019

Language: Английский

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Determinants of enhancer and promoter activities of regulatory elements

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 21(2), P. 71 - 87

Published: Oct. 11, 2019

Language: Английский

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Recent advancements in molecular marker-assisted selection and applications in plant breeding programmes

Journal of Genetic Engineering and Biotechnology, Journal Year: 2021, Volume and Issue: 19(1), P. 128 - 128

Published: Aug. 27, 2021

DNA markers improved the productivity and accuracy of classical plant breeding by means marker-assisted selection (MAS). The enormous number quantitative trait loci (QTLs) mapping read for different species have given a plenitude molecular marker-gene associations. In this review, we discussed positive aspects its precise applications in programmes. Molecular has considerably shortened time new crop varieties to be brought market. To explore information about markers, many reviews been published last few decades; all these were intended breeders obtain on genetics. synopsis recent developments their application programmes devoted early with little or no knowledge markers. progress made breeding, genetics, genomics selection, editing genome contributed comprehensive understanding provides several proofs genetic diversity available plants greatly complemented devices. MAS revolutionized process acceleration accuracy, which is continuously empowering around world.

Language: Английский

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A joint NCBI and EMBL-EBI transcript set for clinical genomics and research

Nature, Journal Year: 2022, Volume and Issue: 604(7905), P. 310 - 315

Published: April 6, 2022

Abstract Comprehensive genome annotation is essential to understand the impact of clinically relevant variants. However, absence a standard for clinical reporting and browser display complicates process consistent interpretation reporting. To address these challenges, Ensembl/GENCODE 1 RefSeq 2 launched joint initiative, Matched Annotation from NCBI EMBL-EBI (MANE) collaboration, converge on human gene transcript jointly define high-value set transcripts corresponding proteins. Here, we describe MANE sets use as universal standards variant display. The Select identifies representative each protein-coding gene, whereas Plus Clinical provides additional at loci where alone are not sufficient report all currently known Each represents an exact match between exonic sequences its counterpart in such that identifiers can be used synonymously. We have now released 97% genes, including American College Medical Genetics Genomics Secondary Findings list v3.0 (ref. 3 ) genes. accessible major browsers key resources. Widespread adoption will increase consistency reporting, facilitate exchange data regardless source help streamline interpretation.

Language: Английский

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The molecular principles of gene regulation by Polycomb repressive complexes

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(12), P. 815 - 833

Published: Aug. 16, 2021

Language: Английский

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Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

Nature Cell Biology, Journal Year: 2019, Volume and Issue: 21(10), P. 1286 - 1299

Published: Sept. 30, 2019

Language: Английский

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The DNA damage response to transcription stress

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(12), P. 766 - 784

Published: Sept. 26, 2019

Language: Английский

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Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

Science China Life Sciences, Journal Year: 2020, Volume and Issue: 63(7), P. 953 - 985

Published: April 30, 2020

Language: Английский

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The epigenetic basis of cellular heterogeneity

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 22(4), P. 235 - 250

Published: Nov. 26, 2020

Language: Английский

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