Intratumoral heterogeneity in cancer progression and response to immunotherapy

Nature Medicine, Год журнала: 2021, Номер 27(2), С. 212 - 224

Опубликована: Фев. 1, 2021

Язык: Английский

---

The role of ubiquitination in tumorigenesis and targeted drug discovery

Signal Transduction and Targeted Therapy, Год журнала: 2020, Номер 5(1)

Опубликована: Фев. 29, 2020

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a crucial role in controlling substrate degradation and subsequently mediates the "quantity" "quality" various proteins, serving to ensure cell homeostasis guarantee life activities. The regulation ubiquitination is multifaceted works not only at transcriptional levels (phosphorylation, acetylation, methylation, etc.) but also level (activators or repressors). When regulatory mechanisms are aberrant, altered biological processes may induce serious human diseases, especially types cancer. In tumorigenesis, involve tumor metabolism, immunological microenvironment (TME), cancer stem (CSC) stemness so on. With regard some key proteins such as RagA, mTOR, PTEN, AKT, c-Myc P53 significantly regulates activity mTORC1, AMPK PTEN-AKT signaling pathways. addition, TLR, RLR STING-dependent pathways modulates TME. Moreover, core regulator triplets (Nanog, Oct4 Sox2) members Wnt Hippo-YAP participates maintenance CSC stemness. Based on components, including proteasome, E3 ligases, E1, E2 deubiquitinases (DUBs), many molecular targeted drugs have been developed combat Among them, small molecule inhibitors targeting bortezomib, carfilzomib, oprozomib ixazomib, achieved tangible success. MLN7243 MLN4924 (targeting E1 enzyme), Leucettamol A CC0651 nutlin MI-219 compounds G5 F6 DUB activity) shown potential preclinical treatment. this review, we summarize latest progress understanding substrates for their special functions metabolism regulation, TME modulation maintenance. therapeutic targets reviewed, effects drugs.

Язык: Английский

---

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

Cancer Cell, Год журнала: 2020, Номер 37(2), С. 147 - 156

Опубликована: Фев. 1, 2020

Язык: Английский

---

Metabolism of Amino Acids in Cancer

Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 8

Опубликована: Янв. 12, 2021

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism amino acids are aberrantly upregulated in many cancers that display addiction to particular acids. Amino facilitate the survival proliferation cancer cells under genotoxic, oxidative, nutritional stress. Thus, targeting acid is becoming potential therapeutic strategy for patients. In this review, we will systematically summarize recent progress malignancy discuss their interconnection with mammalian target rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth immunity, ferroptosis. Finally, highlight applications.

Язык: Английский

---

The language of chromatin modification in human cancers

Nature reviews. Cancer, Год журнала: 2021, Номер 21(7), С. 413 - 430

Опубликована: Май 17, 2021

Язык: Английский

---

Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

Nature reviews. Cancer, Год журнала: 2019, Номер 20(1), С. 57 - 70

Опубликована: Дек. 5, 2019

Язык: Английский

---

Cell cycle on the crossroad of tumorigenesis and cancer therapy

Trends in Cell Biology, Год журнала: 2021, Номер 32(1), С. 30 - 44

Опубликована: Июль 22, 2021

Язык: Английский

---

Tumour fatty acid metabolism in the context of therapy resistance and obesity

Nature reviews. Cancer, Год журнала: 2021, Номер 21(12), С. 753 - 766

Опубликована: Авг. 20, 2021

Язык: Английский

---

Persistent Cancer Cells: The Deadly Survivors

Cell, Год журнала: 2020, Номер 183(4), С. 860 - 874

Опубликована: Ноя. 1, 2020

Язык: Английский

---

Steps in metastasis: an updated review

Medical Oncology, Год журнала: 2021, Номер 38(1)

Опубликована: Янв. 1, 2021

Язык: Английский

---