Nano-Micro Letters, Год журнала: 2022, Номер 14(1)
Опубликована: Июль 18, 2022
As the indispensable second cellular messenger, calcium signaling is involved in regulation of almost all physiological processes by activating specific target proteins. The importance ions (Ca
Язык: Английский
Cell Metabolism, Год журнала: 2021, Номер 33(9), С. 1726 - 1743
Опубликована: Авг. 11, 2021
Язык: Английский
Процитировано
192
Blood, Год журнала: 2019, Номер 134(13), С. 1014 - 1023
Опубликована: Авг. 15, 2019
Язык: Английский
Процитировано
182
ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(46), С. 51249 - 51262
Опубликована: Ноя. 9, 2020
Glucose oxidase (GOx)-mediated starvation therapy has demonstrated good application prospect in cancer treatment. However, the glucose- and oxygen-depletion still suffers from some limitations like low therapeutic efficiency potential side effects to normal tissues. To overcome these disadvantages, herein a novel enzymatic cascade nanoreactor (Pd@Pt-GOx/hyaluronic acid (HA)) with controllable activities was developed for high-efficiency starving-enhanced chemodynamic therapy. The Pd@Pt-GOx/HA fabricated by covalent conjugation of GOx onto Pd@Pt nanosheets (NSs), followed linkage hyaluronic (HA). modification HA on Pd@Pt-GOx could block activity, catalase (CAT)-like peroxidase (POD)-like Pd@Pt, reduce cytotoxicity cells organs, effectively target CD44-overexpressed tumors active targeting passive enhanced permeability retention (EPR) effect. After endocytosis tumor cells, intracellular hyaluronidase (Hyase) decompose outer expose reaction. catalyze oxidation intratumoral glucose O2 therapy, while produced decomposition endogenous H2O2 CAT-like activity accelerate O2-dependent depletion GOx. Meanwhile, upregulated acidity content region generated catalytic dramatically facilitated pH-responsive POD-like nanozyme, which then catalyzed degradation generate abundant highly toxic •OH, thereby realizing nanozyme-mediated In vitro vivo results indicated that controllable, self-activated nanoreactors exerted efficient anticancer negligible biotoxicity.
Язык: Английский
Процитировано
170
International Journal of Biological Sciences, Год журнала: 2020, Номер 16(7), С. 1194 - 1206
Опубликована: Янв. 1, 2020
Metabolic reprogramming is a hallmark of cancer. Mammalian genome characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long (lncRNAs) are freshly discovered functional ncRNAs exerting extensive regulatory impact through diverse mechanisms. Emerging studies have revealed widespread roles lncRNAs in the regulation various cellular activities, including metabolic pathways. In this review, we summarize latest advances regarding cancer metabolism, particularly their mitochondrial function, glucose, glutamine, and lipid metabolism. Moreover, discuss clinical application challenges targeting Understanding complex special behavior will allow better depiction networks permit development lncRNA-based therapies
Язык: Английский
Процитировано
152
Science, Год журнала: 2022, Номер 377(6602)
Опубликована: Июнь 16, 2022
Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is insufficient trigger HIF1α damaged epithelium. Instead, multimodal single-cell and spatial transcriptomics analyses functional studies reveal retinoic acid-related orphan receptor γt
Язык: Английский
Процитировано
149
Nature Reviews Endocrinology, Год журнала: 2021, Номер 17(6), С. 350 - 363
Опубликована: Апрель 29, 2021
Язык: Английский
Процитировано
148
Cancer & Metabolism, Год журнала: 2021, Номер 9(1)
Опубликована: Янв. 7, 2021
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation cell-extrinsic influences, including growth factor nutrient availability. Alongside glucose amino acid metabolism, fatty supports tumorigenesis disease progression through a range of processes membrane biosynthesis, energy storage production, generation signaling intermediates. Here, we highlight complexity in cancer, various inputs outputs intracellular free pool, numerous ways these pathways influence behavior.
Язык: Английский
Процитировано
147
Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2021, Номер 49(4), С. 287 - 298
Опубликована: Ноя. 29, 2021
Maintaining metabolic homeostasis is essential for cellular and organismal health throughout life. Multiple signaling pathways that regulate metabolism also play critical roles in aging, such as PI3K/AKT, mTOR, AMPK, sirtuins (SIRTs). Among them, are known a protein family with versatile functions, control, epigenetic modification lifespan extension. Therefore, by understanding how processes, we can start to understand they slow down or accelerate biological aging from the perspectives of regulation. Here, review biology SIRT3, SIRT4, SIRT5, mitochondrial due their localization matrix. First, will discuss canonical more broadly these integrated Then, summarize current knowledge about functional differences between SIRT5 control integration networks. Finally, processes associated aging-related diseases.
Язык: Английский
Процитировано
147
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Янв. 1, 2024
Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination
Язык: Английский
Процитировано
143
Experimental Hematology and Oncology, Год журнала: 2022, Номер 11(1)
Опубликована: Апрель 23, 2022
During the course of tumorigenesis and subsequent metastasis, malignant cells gradually diversify become more heterogeneous. Consequently, tumor mass might be infiltrated by diverse immune-related components, including cytokine/chemokine environment, cytotoxic activity, or immunosuppressive elements. This immunological heterogeneity is universally presented spatially varies temporally along with evolution therapeutic intervention across almost all solid tumors. The anti-tumor immunity shows a profound association progression disease responsiveness to treatment, particularly in realm immunotherapy. Therefore, an accurate understanding essential for development effective therapies. Facilitated multi-regional -omics sequencing, single cell longitudinal liquid biopsy approaches, recent studies have demonstrated potential investigate complexity tumors its clinical relevance Here, we aimed review mechanism underlying immune microenvironment. We also explored how assessments facilitate personalized
Язык: Английский
Процитировано
136